Q254L5 (Q254L5_CHLFF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA2 EMBL BAE81273.1
Synonyms:	gyrA HAMAP MF_01897
Ordered Locus Names:	CF0501

Organism

Chlamydophila felis (strain Fe/C-56) [Complete proteome] [HAMAP]

Taxonomic identifier

264202 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length	830 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q254L5 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 550B11418F679FB6	FASTA	830	93,495
	10 20 30 40 50 60 MFNKEEIIVP KNLEEEMKES YLRYSMSVII SRALPDVRDG LKPSQRRILF AMKQLNLTPG 70 80 90 100 110 120 AKHRKCAKIC GDTSGDYHPH GESVIYPTLV RMAQNWAMRY PLVDGQGNFG SIDGDPAAAM 130 140 150 160 170 180 RYTEARLTHS AISLMEDLDK DTVDMVSNYD ETKHEPVVFP SKFPNLLCNG SSGIAVGMAT 190 200 210 220 230 240 NIPPHNLGEL IEATLLVLSK PDASIEEILE VMPGPDFPTG GLICGSEGIR STYYTGRGKI 250 260 270 280 290 300 KLRARLHIEE NADKHRENII LTEMPYNVNK SRLIEQIADL VNDKTLAGIH DVRDESDKDG 310 320 330 340 350 360 IRVVLELKKG ESSEIVINRL YKFTDVQVTF GANMLALDKN LPRTMNIHRM ISAWIRHRTE 370 380 390 400 410 420 VIRRRTRYEL NKAEARAHIL EGFLKALSCL DDLVRTIRNS DSKEHAKHQL IENFGFTEQQ 430 440 450 460 470 480 SVAILELRLY QLTGLESEKI QKEYDELINK IAYYKRVLAD EGLVKDIIRN ELQDLQKLHK 490 500 510 520 530 540 TPRRTTIEFD ADDVRDIEDI ITNEPVIITI SGDDYVKRMP IKVFREQKRG GHGVSGFDMK 550 560 570 580 590 600 KGSDFLKSVY SASTKDYLLI FTNFGQCYWL KVWQLPEGER RAKGKPIINF LEGIRPGEQL 610 620 630 640 650 660 AAVLNIKNFE NAGFLFLATK QGVVKKVSLD AFSNPRKKGI RALEIDEGDE LIAAVRITSE 670 680 690 700 710 720 EEKVMLFTRL GMAVRFPHDK VRPMGRTARG VRGVSLKNEK DRVVACQIVK DDQSVLVVCD 730 740 750 760 770 780 NGFGKRSQVE DFRETNRGGV GVRSILINER NGDVLGAISV TDHDSILLMS AQGQAIRINM 790 800 810 820 830 QDVRVMGRST QGVRLVLVKD GDTLVAMEKL SLNGEETLSG IEEESTSPQV

References

[1]

"Genome sequence of the cat pathogen, Chlamydophila felis." Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H., Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H., Hattori M., Kuhara S., Shirai M. DNA Res. 13:15-23(2006) [PubMed: 16766509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006861 Genomic DNA. Translation: BAE81273.1.
RefSeq	YP_515418.1. NC_007899.1.
3D structure databases
ProteinModelPortal	Q254L5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q254L5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3958801.
GenomeReviews	Gene locus CF0501 in contig AP006861_GR.
KEGG	cfe:CF0501.
PATRIC	20204639. VBIChlFel51660_0526.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TSIPPHR.
PhylomeDB	Q254L5.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q254L5_CHLFF

Accession

Primary (citable) accession number: Q254L5

Entry history

Integrated into UniProtKB/TrEMBL:	April 18, 2006
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)