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Q254J3 (Q254J3_CHLFF) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL BAE81295.1
Ordered Locus Names:CF0523
OrganismChlamydophila felis (strain Fe/C-56) [Complete proteome] [HAMAP]
Taxonomic identifier264202 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region258 – 2625ACP-binding By similarity HAMAP MF_01815

Sites

Active site1161 By similarity HAMAP MF_01815
Active site2571 By similarity HAMAP MF_01815
Active site2871 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q254J3 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: 22AD33876D5B3590

FASTA33335,631
        10         20         30         40         50         60 
MKKTRKASIW ATGSYLPEKI LSNSDLEQMV DTSDEWIVTR TGIKERRIAA ADEYTSIMGA 

        70         80         90        100        110        120 
KAAEKAIEKA GLTKDQIECI IFSTSAPDHI FPSSAALAQA YLGIKEIPAF DCMAACTGYL 

       130        140        150        160        170        180 
YGLSVAKAYV ESGMYNNVLL IAADKLSSFV NYQDRNTCVL FGDGGAACVV GESRPGALEI 

       190        200        210        220        230        240 
TNVNLGADGS VSDLLSLPAG GSRLPASLET LEAGKHFISM EGKEVFKHAV RRMESAAKAC 

       250        260        270        280        290        300 
ISDAGIAEED IDWLVPHQAN ERIIDAIAKR FEIDEAKVFK TLSKYGNTAA SSVCIALDEL 

       310        320        330 
LQSHVINSGE YLLIVAFGGG LSWGAVVLQQ VEG

« Hide

References

[1]"Genome sequence of the cat pathogen, Chlamydophila felis."
Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H., Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H., Hattori M., Kuhara S., Shirai M.
DNA Res. 13:15-23(2006) [PubMed: 16766509] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006861 Genomic DNA. Translation: BAE81295.1.
RefSeqYP_515440.1. NC_007899.1.

3D structure databases

ProteinModelPortalQ254J3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ254J3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3958465.
GenomeReviewsGene locus CF0523 in contig AP006861_GR.
KEGGcfe:CF0523.
PATRIC20204685. VBIChlFel51660_0549.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMAATRIEND.
PhylomeDBQ254J3.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ254J3_CHLFF
AccessionPrimary (citable) accession number: Q254J3
Entry history
Integrated into UniProtKB/TrEMBL: April 18, 2006
Last sequence update: April 18, 2006
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info