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Q25490

- APLP_MANSE

UniProt

Q25490 - APLP_MANSE

Protein

Apolipophorins

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. May be required for morphogens wingless (wg) and hedgehog (hh) function, possibly by acting as vehicles for the movement of wg and hh By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei711 – 7122Cleavage; by furinBy similarity

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. lipid transporter activity Source: InterPro

    GO - Biological processi

    1. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport, Wnt signaling pathway

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipophorins
    Cleaved into the following 2 chains:
    Alternative name(s):
    Apolipophorin II
    apoLp-2
    Alternative name(s):
    Apolipophorin I
    apoLp-1
    OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
    Taxonomic identifieri7130 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 711688Apolipophorin-2By similarityPRO_0000041530Add
    BLAST
    Chaini712 – 33052594Apolipophorin-1By similarityPRO_0000041531Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2769 – 27691N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Cleaved into 2 chains by furin protease. However, prevention of cleavage does not impair its function By similarity.By similarity
    N-glycosylated.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ25490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 640602VitellogeninPROSITE-ProRule annotationAdd
    BLAST
    Domaini2734 – 2929196VWFDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 vitellogenin domain.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.25.10.20. 1 hit.
    2.20.50.20. 2 hits.
    2.20.80.10. 1 hit.
    2.30.230.10. 1 hit.
    InterProiIPR015819. Lipid_transp_b-sht_shell.
    IPR001747. Lipid_transpt_N.
    IPR009454. Lipid_transpt_open_b-sht.
    IPR015816. Vitellinogen_b-sht_N.
    IPR015255. Vitellinogen_open_b-sht.
    IPR015817. Vitellinogen_open_b-sht_sub1.
    IPR015818. Vitellinogen_open_b-sht_sub2.
    IPR011030. Vitellinogen_superhlx.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF06448. DUF1081. 1 hit.
    PF09172. DUF1943. 1 hit.
    PF01347. Vitellogenin_N. 1 hit.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00638. LPD_N. 1 hit.
    SM00216. VWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF48431. SSF48431. 1 hit.
    SSF56968. SSF56968. 2 hits.
    PROSITEiPS51211. VITELLOGENIN. 1 hit.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q25490-1 [UniParc]FASTAAdd to Basket

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    MGKSNRLLSV LFVISVLWKA AYGNGKCQIA CKGSSSPSFA AGQKYNYGVE     50
    GTVSVYLTGA DNQETSLKML GQASVSAISN CELELSVHNM VLSGPDGKKY 100
    PCPQGIEKPV RFSYQDGRVG PEICAAEDDS RRSLNIKRAI ISLLQAEQKP 150
    SVQVDVFGVC PTEVSSSQEG GAVLLHRSRD LSRCAHREQG RNDFVNSIAN 200
    PDAGIKDLQV LQSMLNVESK VNNGVPEKVS AIEEYLYKPF SVGENGARAK 250
    VHTKLTLSGK GGAGGGNAHC TESRSIIFDV PHGTSSASGN LNSVISAVKE 300
    TARTVANDAS SKSAGQFAQL VRIMRTSSKD DLMRIYSQVK AHQLEKRVYL 350
    DALLRAGTGE SIEASIQILK SKDLSQLEQH LVFLSLGNAR HVNNPALKAA 400
    AGLLDMPNLP KEVYLGAGAL GGAYCREHDC HNVKPEGIVA LSNKLGSKLQ 450
    NCRPKNKPDE DVVVAILKGI RNIRHLEDSL IDKLVHCAVD NNVKARVRAV 500
    ALEAFHADPC SAKIHKTAMD IMKNRQLDSE IRIKAYLAVI ECPCSHSASE 550
    IKNLLDSEPV HQVGNFITSS LRHIRSSSNP DKQLAKKHYG QIRTPNKFKV 600
    DERKYSFYRE MSYKLDALGA GGSVDQTVIY SQTSFLPRSV NFNLTVDLFG 650
    QSYNVMELGG RQGNLDRVVE HFLGPKSFLR TEDPQALYDN LVKRFQESKK 700
    KVEDSLSRGR RSIKSEIDVF DKNLKAESAP YNNELDLDIY VKLFGTDAVF 750
    LSFGDDKGFD FNKMLDQILG GCNSGINKAK HFQQEIRSHL LFMDAELAYP 800
    TSVGLPLRLN LIGAATARLD VATNIDIRQI FQSPQNAKAD IKFVPSTDFE 850
    ISGAFIIDAD AFSTGIKVIT NLHSSTGVHV NAKVLENGRG IDLQIGLPVD 900
    KQELIAASSD LVFVTAEKGQ KEKQKVIKME KGENEYSACF DQLSGPLGLT 950
    MCYDMVLPFP IVNRNDKLDS IAKAMGKWPL SGSAKFKLFL EKNDLRGYHI 1000
    KAVVKEDKDA GRRSFELLLD TEGAKTRRSQ LTGEAVYNEN EVGVKLGLEA 1050
    VGKVIYGHIW AHKKPNELVA SVKGKLDDIE YSGKLGFSVQ GNEHRAVYKP 1100
    IFEYSLPDGS SPGSKKYEVK IDGQVIRECD GRVTKYTFDG VHVNLQNAEK 1150
    PLEICGSVST VAQPREVEFD VEVKHYASLK GSWKGSDVVL AFNNQLNPKI 1200
    NFDLKGKFEN TDSMHNELDI HYGPNRGDNN ARITFSQILK YHVENSKNFN 1250
    VITKNNLEIR AVPFKLVANA DVDPKKIDID IEGQLQDKSA GFNLDARTHI 1300
    KKEGDYSIKV KANLNNANLE AFSRRDIVNA EKSNVENYID MKGVGRYELS 1350
    GFVLHKTKPN DVNVGFIGHL KINGGGKNED FKINIGHIET PAVFSSHATI 1400
    SGSRGDIIDY LLKIMRTANP NGNFKLVIKD SIAANGQYKV TDADGKGNGL 1450
    IIIDFKKINR KIKGDVRFTA KEPVFNADID LFLNFEKDNS DKVHFSTYNK 1500
    KTDKVMDTKN KLEYAGKRTE VNIHQDGILA VTGKAHTVAE LVLPTERCLS 1550
    LKIDHDGAFK DGLYNGHMDM TISDAPKRGS GASTISYKGK VSNSNLDQEI 1600
    IDYEGQINFK LKDGKNLQST FSLKNNPDGD KFKYEFKSDV NGNLIPKPAN 1650
    LVATGTYSNS ENEIDETYRL KGSYGSDIGF ELAGVGTIKF LDAGDKKYLD 1700
    DYTLTVRLPF EKAHDIKWVS TVLFLQPQGQ EMTEYTLVES VQINADVYKI 1750
    DANGKVGPKN GYGAVKVLVP HVEPFVLDYN YKSSHEGEKN NNYVELKTKY 1800
    GKGKSASMVV DSSYAPHYST LKVKANTPNN DKFKKLDVTV HSKNPSPDAY 1850
    SNSVVVDADG RVYKIDSSIV LSKAHPVLDI QYHSPSSDKI RRLYLQGSSL 1900
    SSTQGKLEVK VDNINDICLD AVSEANVQKD NVAFKVVANA KELGWKNYGI 1950
    DISSKDSGSG KRLEFHATND NKNVLSGSTS FISKQEGQKT IIEGSGSVKV 2000
    KEEQKSANFK YIRTVFTDSN EKGVETFFNV ALGERSYVAE SRVTNYEYKN 2050
    SYVYCEEKKQ CAHAEIQSKI DMSTPGMIVN VINAGLDLRK LGVAPELGLQ 2100
    MRDEVSDRRP PRFTLDLHIN KEDRKYHLHA YNTPENGHYA SGVTVRLPSR 2150
    VMALEYTLTH PTSQDLPFPI KGEACLDLDK NRPGHKTSAR FLVDYSNSGS 2200
    EDKAVAEIGF FHPKIEKEAV IRLNAFMKRP ENGCFKIESS ASLCHSALGT 2250
    DRVAKVMFET TPNSVKFLAD TPFVKAIDVE GSFNVNQQQR TQQCLFRICL 2300
    LEGKPVQMSA LVKDYQYYEF TTEESNRKLS YVGHLIPEKR VDISTDIILS 2350
    GDKKNIAHGA LFLQDNLVKS DYGLSKENFN YFLNALKKDL DTLEDRIKNV 2400
    GEKASKDVEA VTQRAAPYFK KVEDNFRAEW NRFYQEIADD KVFKEISHVF 2450
    NEIVQYIAKF IDEILQGTKR SWTPSCRPTL SHPRNREMYK KQIEPQVKQL 2500
    YDTLGALMKE YLDGVIDVVA HFAAIVTDFF EKHKAELQEL TNVFTEIFKD 2550
    LTRLVVAQLK ELPPKIAQIY NDIVSQITNM PFVVVLQEKW KEFNFAERAV 2600
    QLVSQAYEAF SKILPTDELK EFAKALNAYL LKKIKEEKME ESKELPRAVR 2650
    EAGQRVLLIT SIPALAVRRP RLRRWTWHHL KLAVGAGASA PSLGAASWSA 2700
    LRQLAAGDGP PALAPRGLPT AQLDPLDEVP NKLRAVVVNG QHIFTFDGRH 2750
    LTFPGTCRYV LIHDHVDRNF TVLMQLANGQ PKALVLEDKS GTIIELKDNG 2800
    QVILNCQSHG FPVVEQDVFA FRQTSGRIGL CSKYGLMAFC TSKFEVCYFE 2850
    VNGFYLGKLP GLLGDGNNEP YDDFRMPNGK ICSSESEFGN SYRLSRSCPA 2900
    ANAPAHDHHQ MHAPLPKPCE RVFSGTSPLR PLSLMLDIAP FRQACIHAVT 2950
    GADADKDLQQ ACDLARGYRR SRSRGCCPPR CPTPACAART ATGPGSWATP 3000
    TSTNCPTDSL ISSSPLRPLR TTPAHYKNMV VPLVSQLVDM LKGKHCTDIK 3050
    VFLVGHTSKH PYPILYDTDL KLKNAKVSFD DKSRYDRIPF VKTGHEKFDS 3100
    YSKTVVDFLN YIKIELGITN IEASQGQIFD LPLRPGAVKH VIFVTGGPTI 3150
    SQFFLLETVR ALRNKVIIDE MAMSASLVTS TPGLKIGGGK NAAQIVGYEK 3200
    HGVLLLGEKK QSKDSEAVRA TLEVEDDPFS DAVEFANGVV FSASNYAALP 3250
    AGQQKQFIQT AAHNIIQRMW REQIVQQCTC VFVDPFRVRS VCFNKARTEV 3300
    ARRRK 3305
    Length:3,305
    Mass (Da):366,947
    Last modified:November 1, 1996 - v1
    Checksum:iB27D611410285FD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57651 mRNA. Translation: AAB53254.1.
    PIRiT18358.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Lipid freight - Issue 59 of June 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57651 mRNA. Translation: AAB53254.1 .
    PIRi T18358.

    3D structure databases

    ProteinModelPortali Q25490.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.25.10.20. 1 hit.
    2.20.50.20. 2 hits.
    2.20.80.10. 1 hit.
    2.30.230.10. 1 hit.
    InterProi IPR015819. Lipid_transp_b-sht_shell.
    IPR001747. Lipid_transpt_N.
    IPR009454. Lipid_transpt_open_b-sht.
    IPR015816. Vitellinogen_b-sht_N.
    IPR015255. Vitellinogen_open_b-sht.
    IPR015817. Vitellinogen_open_b-sht_sub1.
    IPR015818. Vitellinogen_open_b-sht_sub2.
    IPR011030. Vitellinogen_superhlx.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF06448. DUF1081. 1 hit.
    PF09172. DUF1943. 1 hit.
    PF01347. Vitellogenin_N. 1 hit.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00638. LPD_N. 1 hit.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48431. SSF48431. 1 hit.
    SSF56968. SSF56968. 2 hits.
    PROSITEi PS51211. VITELLOGENIN. 1 hit.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The precursor protein of the structural apolipoproteins of lipophorin: cDNA and deduced amino acid sequence."
      Sundermeyer K., Hendricks J.K., Prasad S.V., Wells M.A.
      Insect Biochem. Mol. Biol. 26:735-738(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fat body.

    Entry informationi

    Entry nameiAPLP_MANSE
    AccessioniPrimary (citable) accession number: Q25490
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3