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Q25490

- APLP_MANSE

UniProt

Q25490 - APLP_MANSE

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Protein

Apolipophorins

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. May be required for morphogens wingless (wg) and hedgehog (hh) function, possibly by acting as vehicles for the movement of wg and hh (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei711 – 7122Cleavage; by furinBy similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. lipid transporter activity Source: InterPro

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport, Wnt signaling pathway

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipophorins
Cleaved into the following 2 chains:
Alternative name(s):
Apolipophorin II
apoLp-2
Alternative name(s):
Apolipophorin I
apoLp-1
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 711688Apolipophorin-2By similarityPRO_0000041530Add
BLAST
Chaini712 – 33052594Apolipophorin-1By similarityPRO_0000041531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2769 – 27691N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Cleaved into 2 chains by furin protease. However, prevention of cleavage does not impair its function (By similarity).By similarity
N-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ25490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 640602VitellogeninPROSITE-ProRule annotationAdd
BLAST
Domaini2734 – 2929196VWFDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q25490-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGKSNRLLSV LFVISVLWKA AYGNGKCQIA CKGSSSPSFA AGQKYNYGVE
60 70 80 90 100
GTVSVYLTGA DNQETSLKML GQASVSAISN CELELSVHNM VLSGPDGKKY
110 120 130 140 150
PCPQGIEKPV RFSYQDGRVG PEICAAEDDS RRSLNIKRAI ISLLQAEQKP
160 170 180 190 200
SVQVDVFGVC PTEVSSSQEG GAVLLHRSRD LSRCAHREQG RNDFVNSIAN
210 220 230 240 250
PDAGIKDLQV LQSMLNVESK VNNGVPEKVS AIEEYLYKPF SVGENGARAK
260 270 280 290 300
VHTKLTLSGK GGAGGGNAHC TESRSIIFDV PHGTSSASGN LNSVISAVKE
310 320 330 340 350
TARTVANDAS SKSAGQFAQL VRIMRTSSKD DLMRIYSQVK AHQLEKRVYL
360 370 380 390 400
DALLRAGTGE SIEASIQILK SKDLSQLEQH LVFLSLGNAR HVNNPALKAA
410 420 430 440 450
AGLLDMPNLP KEVYLGAGAL GGAYCREHDC HNVKPEGIVA LSNKLGSKLQ
460 470 480 490 500
NCRPKNKPDE DVVVAILKGI RNIRHLEDSL IDKLVHCAVD NNVKARVRAV
510 520 530 540 550
ALEAFHADPC SAKIHKTAMD IMKNRQLDSE IRIKAYLAVI ECPCSHSASE
560 570 580 590 600
IKNLLDSEPV HQVGNFITSS LRHIRSSSNP DKQLAKKHYG QIRTPNKFKV
610 620 630 640 650
DERKYSFYRE MSYKLDALGA GGSVDQTVIY SQTSFLPRSV NFNLTVDLFG
660 670 680 690 700
QSYNVMELGG RQGNLDRVVE HFLGPKSFLR TEDPQALYDN LVKRFQESKK
710 720 730 740 750
KVEDSLSRGR RSIKSEIDVF DKNLKAESAP YNNELDLDIY VKLFGTDAVF
760 770 780 790 800
LSFGDDKGFD FNKMLDQILG GCNSGINKAK HFQQEIRSHL LFMDAELAYP
810 820 830 840 850
TSVGLPLRLN LIGAATARLD VATNIDIRQI FQSPQNAKAD IKFVPSTDFE
860 870 880 890 900
ISGAFIIDAD AFSTGIKVIT NLHSSTGVHV NAKVLENGRG IDLQIGLPVD
910 920 930 940 950
KQELIAASSD LVFVTAEKGQ KEKQKVIKME KGENEYSACF DQLSGPLGLT
960 970 980 990 1000
MCYDMVLPFP IVNRNDKLDS IAKAMGKWPL SGSAKFKLFL EKNDLRGYHI
1010 1020 1030 1040 1050
KAVVKEDKDA GRRSFELLLD TEGAKTRRSQ LTGEAVYNEN EVGVKLGLEA
1060 1070 1080 1090 1100
VGKVIYGHIW AHKKPNELVA SVKGKLDDIE YSGKLGFSVQ GNEHRAVYKP
1110 1120 1130 1140 1150
IFEYSLPDGS SPGSKKYEVK IDGQVIRECD GRVTKYTFDG VHVNLQNAEK
1160 1170 1180 1190 1200
PLEICGSVST VAQPREVEFD VEVKHYASLK GSWKGSDVVL AFNNQLNPKI
1210 1220 1230 1240 1250
NFDLKGKFEN TDSMHNELDI HYGPNRGDNN ARITFSQILK YHVENSKNFN
1260 1270 1280 1290 1300
VITKNNLEIR AVPFKLVANA DVDPKKIDID IEGQLQDKSA GFNLDARTHI
1310 1320 1330 1340 1350
KKEGDYSIKV KANLNNANLE AFSRRDIVNA EKSNVENYID MKGVGRYELS
1360 1370 1380 1390 1400
GFVLHKTKPN DVNVGFIGHL KINGGGKNED FKINIGHIET PAVFSSHATI
1410 1420 1430 1440 1450
SGSRGDIIDY LLKIMRTANP NGNFKLVIKD SIAANGQYKV TDADGKGNGL
1460 1470 1480 1490 1500
IIIDFKKINR KIKGDVRFTA KEPVFNADID LFLNFEKDNS DKVHFSTYNK
1510 1520 1530 1540 1550
KTDKVMDTKN KLEYAGKRTE VNIHQDGILA VTGKAHTVAE LVLPTERCLS
1560 1570 1580 1590 1600
LKIDHDGAFK DGLYNGHMDM TISDAPKRGS GASTISYKGK VSNSNLDQEI
1610 1620 1630 1640 1650
IDYEGQINFK LKDGKNLQST FSLKNNPDGD KFKYEFKSDV NGNLIPKPAN
1660 1670 1680 1690 1700
LVATGTYSNS ENEIDETYRL KGSYGSDIGF ELAGVGTIKF LDAGDKKYLD
1710 1720 1730 1740 1750
DYTLTVRLPF EKAHDIKWVS TVLFLQPQGQ EMTEYTLVES VQINADVYKI
1760 1770 1780 1790 1800
DANGKVGPKN GYGAVKVLVP HVEPFVLDYN YKSSHEGEKN NNYVELKTKY
1810 1820 1830 1840 1850
GKGKSASMVV DSSYAPHYST LKVKANTPNN DKFKKLDVTV HSKNPSPDAY
1860 1870 1880 1890 1900
SNSVVVDADG RVYKIDSSIV LSKAHPVLDI QYHSPSSDKI RRLYLQGSSL
1910 1920 1930 1940 1950
SSTQGKLEVK VDNINDICLD AVSEANVQKD NVAFKVVANA KELGWKNYGI
1960 1970 1980 1990 2000
DISSKDSGSG KRLEFHATND NKNVLSGSTS FISKQEGQKT IIEGSGSVKV
2010 2020 2030 2040 2050
KEEQKSANFK YIRTVFTDSN EKGVETFFNV ALGERSYVAE SRVTNYEYKN
2060 2070 2080 2090 2100
SYVYCEEKKQ CAHAEIQSKI DMSTPGMIVN VINAGLDLRK LGVAPELGLQ
2110 2120 2130 2140 2150
MRDEVSDRRP PRFTLDLHIN KEDRKYHLHA YNTPENGHYA SGVTVRLPSR
2160 2170 2180 2190 2200
VMALEYTLTH PTSQDLPFPI KGEACLDLDK NRPGHKTSAR FLVDYSNSGS
2210 2220 2230 2240 2250
EDKAVAEIGF FHPKIEKEAV IRLNAFMKRP ENGCFKIESS ASLCHSALGT
2260 2270 2280 2290 2300
DRVAKVMFET TPNSVKFLAD TPFVKAIDVE GSFNVNQQQR TQQCLFRICL
2310 2320 2330 2340 2350
LEGKPVQMSA LVKDYQYYEF TTEESNRKLS YVGHLIPEKR VDISTDIILS
2360 2370 2380 2390 2400
GDKKNIAHGA LFLQDNLVKS DYGLSKENFN YFLNALKKDL DTLEDRIKNV
2410 2420 2430 2440 2450
GEKASKDVEA VTQRAAPYFK KVEDNFRAEW NRFYQEIADD KVFKEISHVF
2460 2470 2480 2490 2500
NEIVQYIAKF IDEILQGTKR SWTPSCRPTL SHPRNREMYK KQIEPQVKQL
2510 2520 2530 2540 2550
YDTLGALMKE YLDGVIDVVA HFAAIVTDFF EKHKAELQEL TNVFTEIFKD
2560 2570 2580 2590 2600
LTRLVVAQLK ELPPKIAQIY NDIVSQITNM PFVVVLQEKW KEFNFAERAV
2610 2620 2630 2640 2650
QLVSQAYEAF SKILPTDELK EFAKALNAYL LKKIKEEKME ESKELPRAVR
2660 2670 2680 2690 2700
EAGQRVLLIT SIPALAVRRP RLRRWTWHHL KLAVGAGASA PSLGAASWSA
2710 2720 2730 2740 2750
LRQLAAGDGP PALAPRGLPT AQLDPLDEVP NKLRAVVVNG QHIFTFDGRH
2760 2770 2780 2790 2800
LTFPGTCRYV LIHDHVDRNF TVLMQLANGQ PKALVLEDKS GTIIELKDNG
2810 2820 2830 2840 2850
QVILNCQSHG FPVVEQDVFA FRQTSGRIGL CSKYGLMAFC TSKFEVCYFE
2860 2870 2880 2890 2900
VNGFYLGKLP GLLGDGNNEP YDDFRMPNGK ICSSESEFGN SYRLSRSCPA
2910 2920 2930 2940 2950
ANAPAHDHHQ MHAPLPKPCE RVFSGTSPLR PLSLMLDIAP FRQACIHAVT
2960 2970 2980 2990 3000
GADADKDLQQ ACDLARGYRR SRSRGCCPPR CPTPACAART ATGPGSWATP
3010 3020 3030 3040 3050
TSTNCPTDSL ISSSPLRPLR TTPAHYKNMV VPLVSQLVDM LKGKHCTDIK
3060 3070 3080 3090 3100
VFLVGHTSKH PYPILYDTDL KLKNAKVSFD DKSRYDRIPF VKTGHEKFDS
3110 3120 3130 3140 3150
YSKTVVDFLN YIKIELGITN IEASQGQIFD LPLRPGAVKH VIFVTGGPTI
3160 3170 3180 3190 3200
SQFFLLETVR ALRNKVIIDE MAMSASLVTS TPGLKIGGGK NAAQIVGYEK
3210 3220 3230 3240 3250
HGVLLLGEKK QSKDSEAVRA TLEVEDDPFS DAVEFANGVV FSASNYAALP
3260 3270 3280 3290 3300
AGQQKQFIQT AAHNIIQRMW REQIVQQCTC VFVDPFRVRS VCFNKARTEV

ARRRK
Length:3,305
Mass (Da):366,947
Last modified:November 1, 1996 - v1
Checksum:iB27D611410285FD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57651 mRNA. Translation: AAB53254.1.
PIRiT18358.

Cross-referencesi

Web resourcesi

Protein Spotlight

Lipid freight - Issue 59 of June 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57651 mRNA. Translation: AAB53254.1 .
PIRi T18358.

3D structure databases

ProteinModelPortali Q25490.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProi IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEi PS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The precursor protein of the structural apolipoproteins of lipophorin: cDNA and deduced amino acid sequence."
    Sundermeyer K., Hendricks J.K., Prasad S.V., Wells M.A.
    Insect Biochem. Mol. Biol. 26:735-738(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fat body.

Entry informationi

Entry nameiAPLP_MANSE
AccessioniPrimary (citable) accession number: Q25490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3