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Q25490

- APLP_MANSE

UniProt

Q25490 - APLP_MANSE

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Protein
Apolipophorins
Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Constitutes the major component of lipophorin, which mediates transport for various types of lipids in hemolymph. Acts by forming lipoprotein particles that bind lipoproteins and lipids. May be required for morphogens wingless (wg) and hedgehog (hh) function, possibly by acting as vehicles for the movement of wg and hh By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei711 – 7122Cleavage; by furin By similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. lipid transporter activity Source: InterPro

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport, Wnt signaling pathway

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipophorins
Cleaved into the following 2 chains:
Alternative name(s):
Apolipophorin II
apoLp-2
Alternative name(s):
Apolipophorin I
apoLp-1
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 711688Apolipophorin-2 By similarity
PRO_0000041530Add
BLAST
Chaini712 – 33052594Apolipophorin-1 By similarity
PRO_0000041531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi643 – 6431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2769 – 27691N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Cleaved into 2 chains by furin protease. However, prevention of cleavage does not impair its function By similarity.
N-glycosylated By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ25490.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 640602Vitellogenin
Add
BLAST
Domaini2734 – 2929196VWFD
Add
BLAST

Sequence similaritiesi

Contains 1 VWFD domain.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q25490-1 [UniParc]FASTAAdd to Basket

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MGKSNRLLSV LFVISVLWKA AYGNGKCQIA CKGSSSPSFA AGQKYNYGVE     50
GTVSVYLTGA DNQETSLKML GQASVSAISN CELELSVHNM VLSGPDGKKY 100
PCPQGIEKPV RFSYQDGRVG PEICAAEDDS RRSLNIKRAI ISLLQAEQKP 150
SVQVDVFGVC PTEVSSSQEG GAVLLHRSRD LSRCAHREQG RNDFVNSIAN 200
PDAGIKDLQV LQSMLNVESK VNNGVPEKVS AIEEYLYKPF SVGENGARAK 250
VHTKLTLSGK GGAGGGNAHC TESRSIIFDV PHGTSSASGN LNSVISAVKE 300
TARTVANDAS SKSAGQFAQL VRIMRTSSKD DLMRIYSQVK AHQLEKRVYL 350
DALLRAGTGE SIEASIQILK SKDLSQLEQH LVFLSLGNAR HVNNPALKAA 400
AGLLDMPNLP KEVYLGAGAL GGAYCREHDC HNVKPEGIVA LSNKLGSKLQ 450
NCRPKNKPDE DVVVAILKGI RNIRHLEDSL IDKLVHCAVD NNVKARVRAV 500
ALEAFHADPC SAKIHKTAMD IMKNRQLDSE IRIKAYLAVI ECPCSHSASE 550
IKNLLDSEPV HQVGNFITSS LRHIRSSSNP DKQLAKKHYG QIRTPNKFKV 600
DERKYSFYRE MSYKLDALGA GGSVDQTVIY SQTSFLPRSV NFNLTVDLFG 650
QSYNVMELGG RQGNLDRVVE HFLGPKSFLR TEDPQALYDN LVKRFQESKK 700
KVEDSLSRGR RSIKSEIDVF DKNLKAESAP YNNELDLDIY VKLFGTDAVF 750
LSFGDDKGFD FNKMLDQILG GCNSGINKAK HFQQEIRSHL LFMDAELAYP 800
TSVGLPLRLN LIGAATARLD VATNIDIRQI FQSPQNAKAD IKFVPSTDFE 850
ISGAFIIDAD AFSTGIKVIT NLHSSTGVHV NAKVLENGRG IDLQIGLPVD 900
KQELIAASSD LVFVTAEKGQ KEKQKVIKME KGENEYSACF DQLSGPLGLT 950
MCYDMVLPFP IVNRNDKLDS IAKAMGKWPL SGSAKFKLFL EKNDLRGYHI 1000
KAVVKEDKDA GRRSFELLLD TEGAKTRRSQ LTGEAVYNEN EVGVKLGLEA 1050
VGKVIYGHIW AHKKPNELVA SVKGKLDDIE YSGKLGFSVQ GNEHRAVYKP 1100
IFEYSLPDGS SPGSKKYEVK IDGQVIRECD GRVTKYTFDG VHVNLQNAEK 1150
PLEICGSVST VAQPREVEFD VEVKHYASLK GSWKGSDVVL AFNNQLNPKI 1200
NFDLKGKFEN TDSMHNELDI HYGPNRGDNN ARITFSQILK YHVENSKNFN 1250
VITKNNLEIR AVPFKLVANA DVDPKKIDID IEGQLQDKSA GFNLDARTHI 1300
KKEGDYSIKV KANLNNANLE AFSRRDIVNA EKSNVENYID MKGVGRYELS 1350
GFVLHKTKPN DVNVGFIGHL KINGGGKNED FKINIGHIET PAVFSSHATI 1400
SGSRGDIIDY LLKIMRTANP NGNFKLVIKD SIAANGQYKV TDADGKGNGL 1450
IIIDFKKINR KIKGDVRFTA KEPVFNADID LFLNFEKDNS DKVHFSTYNK 1500
KTDKVMDTKN KLEYAGKRTE VNIHQDGILA VTGKAHTVAE LVLPTERCLS 1550
LKIDHDGAFK DGLYNGHMDM TISDAPKRGS GASTISYKGK VSNSNLDQEI 1600
IDYEGQINFK LKDGKNLQST FSLKNNPDGD KFKYEFKSDV NGNLIPKPAN 1650
LVATGTYSNS ENEIDETYRL KGSYGSDIGF ELAGVGTIKF LDAGDKKYLD 1700
DYTLTVRLPF EKAHDIKWVS TVLFLQPQGQ EMTEYTLVES VQINADVYKI 1750
DANGKVGPKN GYGAVKVLVP HVEPFVLDYN YKSSHEGEKN NNYVELKTKY 1800
GKGKSASMVV DSSYAPHYST LKVKANTPNN DKFKKLDVTV HSKNPSPDAY 1850
SNSVVVDADG RVYKIDSSIV LSKAHPVLDI QYHSPSSDKI RRLYLQGSSL 1900
SSTQGKLEVK VDNINDICLD AVSEANVQKD NVAFKVVANA KELGWKNYGI 1950
DISSKDSGSG KRLEFHATND NKNVLSGSTS FISKQEGQKT IIEGSGSVKV 2000
KEEQKSANFK YIRTVFTDSN EKGVETFFNV ALGERSYVAE SRVTNYEYKN 2050
SYVYCEEKKQ CAHAEIQSKI DMSTPGMIVN VINAGLDLRK LGVAPELGLQ 2100
MRDEVSDRRP PRFTLDLHIN KEDRKYHLHA YNTPENGHYA SGVTVRLPSR 2150
VMALEYTLTH PTSQDLPFPI KGEACLDLDK NRPGHKTSAR FLVDYSNSGS 2200
EDKAVAEIGF FHPKIEKEAV IRLNAFMKRP ENGCFKIESS ASLCHSALGT 2250
DRVAKVMFET TPNSVKFLAD TPFVKAIDVE GSFNVNQQQR TQQCLFRICL 2300
LEGKPVQMSA LVKDYQYYEF TTEESNRKLS YVGHLIPEKR VDISTDIILS 2350
GDKKNIAHGA LFLQDNLVKS DYGLSKENFN YFLNALKKDL DTLEDRIKNV 2400
GEKASKDVEA VTQRAAPYFK KVEDNFRAEW NRFYQEIADD KVFKEISHVF 2450
NEIVQYIAKF IDEILQGTKR SWTPSCRPTL SHPRNREMYK KQIEPQVKQL 2500
YDTLGALMKE YLDGVIDVVA HFAAIVTDFF EKHKAELQEL TNVFTEIFKD 2550
LTRLVVAQLK ELPPKIAQIY NDIVSQITNM PFVVVLQEKW KEFNFAERAV 2600
QLVSQAYEAF SKILPTDELK EFAKALNAYL LKKIKEEKME ESKELPRAVR 2650
EAGQRVLLIT SIPALAVRRP RLRRWTWHHL KLAVGAGASA PSLGAASWSA 2700
LRQLAAGDGP PALAPRGLPT AQLDPLDEVP NKLRAVVVNG QHIFTFDGRH 2750
LTFPGTCRYV LIHDHVDRNF TVLMQLANGQ PKALVLEDKS GTIIELKDNG 2800
QVILNCQSHG FPVVEQDVFA FRQTSGRIGL CSKYGLMAFC TSKFEVCYFE 2850
VNGFYLGKLP GLLGDGNNEP YDDFRMPNGK ICSSESEFGN SYRLSRSCPA 2900
ANAPAHDHHQ MHAPLPKPCE RVFSGTSPLR PLSLMLDIAP FRQACIHAVT 2950
GADADKDLQQ ACDLARGYRR SRSRGCCPPR CPTPACAART ATGPGSWATP 3000
TSTNCPTDSL ISSSPLRPLR TTPAHYKNMV VPLVSQLVDM LKGKHCTDIK 3050
VFLVGHTSKH PYPILYDTDL KLKNAKVSFD DKSRYDRIPF VKTGHEKFDS 3100
YSKTVVDFLN YIKIELGITN IEASQGQIFD LPLRPGAVKH VIFVTGGPTI 3150
SQFFLLETVR ALRNKVIIDE MAMSASLVTS TPGLKIGGGK NAAQIVGYEK 3200
HGVLLLGEKK QSKDSEAVRA TLEVEDDPFS DAVEFANGVV FSASNYAALP 3250
AGQQKQFIQT AAHNIIQRMW REQIVQQCTC VFVDPFRVRS VCFNKARTEV 3300
ARRRK 3305
Length:3,305
Mass (Da):366,947
Last modified:November 1, 1996 - v1
Checksum:iB27D611410285FD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57651 mRNA. Translation: AAB53254.1.
PIRiT18358.

Cross-referencesi

Web resourcesi

Protein Spotlight

Lipid freight - Issue 59 of June 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57651 mRNA. Translation: AAB53254.1 .
PIRi T18358.

3D structure databases

ProteinModelPortali Q25490.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProi IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEi PS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The precursor protein of the structural apolipoproteins of lipophorin: cDNA and deduced amino acid sequence."
    Sundermeyer K., Hendricks J.K., Prasad S.V., Wells M.A.
    Insect Biochem. Mol. Biol. 26:735-738(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fat body.

Entry informationi

Entry nameiAPLP_MANSE
AccessioniPrimary (citable) accession number: Q25490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi