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Protein

Juvenile hormone epoxide hydrolase

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes juvenile hormone hydrolysis.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol.By similarity
1-(4-methoxyphenyl)-N-methyl-N-((3-methyloxetan-3-yl)methyl)methanamine + H2O = 2-((((4-methoxyphenyl)methyl)(methyl)amino)methyl)-2-methylpropane-1,3-diol.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227NucleophileBy similarity1
Active sitei372Proton donorBy similarity1
Active sitei428Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAromatic hydrocarbons catabolism

Protein family/group databases

ESTHERimanse-hyep Epoxide_hydrolase
MEROPSiS33.971

Names & Taxonomyi

Protein namesi
Recommended name:
Juvenile hormone epoxide hydrolase (EC:3.3.2.9By similarity)
Short name:
JHEH
Alternative name(s):
Juvenile hormone-specific epoxide hydrolase
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808621 – 462Juvenile hormone epoxide hydrolaseAdd BLAST462

Interactioni

Chemistry databases

BindingDBiQ25489

Structurei

3D structure databases

ProteinModelPortaliQ25489
SMRiQ25489
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000639 Epox_hydrolase-like
IPR010497 Epoxide_hydro_N
IPR016292 Epoxide_hydrolase
PfamiView protein in Pfam
PF06441 EHN, 1 hit
PIRSFiPIRSF001112 Epoxide_hydrolase, 1 hit
PRINTSiPR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q25489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKILSSFVA GVAIGSGLVI TYVLYNVPEP PELDLQRWWG IGTRPTEEDK
60 70 80 90 100
SIRPFSIDFN DTVILDLKER LKNRRPFTKP LEGINSEYGM NTEYLETVLE
110 120 130 140 150
YWLNEYNFKK RAELLNKFPH YKTRIQGLDL HFIRVKPEIK EGVQVLPLLM
160 170 180 190 200
MHGWPSSSKE FDKVIPILTT PKHEYNIVFE VVAVDLPGYG FSEGTNKPGL
210 220 230 240 250
NPVQIGVMMR NLMLRLGFEK FYIQAGDWGS QCATHMATLF PDQVLGLHTN
260 270 280 290 300
MPLSSRPLST VKLFIGALFP SLIVDAKYMD RIYPLKNLFS YILRETGYFH
310 320 330 340 350
IQATKPDTIG VALTDSPAGL AGYLIEKMAI CSNRDQLDTP HGGLENLNLD
360 370 380 390 400
DVLDTVTINW INNCIVTSTR LYAEGFSWPE VLIVHRIPSM VPTAGINFKY
410 420 430 440 450
EVLYQPDWIL RDKFPNLVRS TVLDFGGHFA ALHTPQALAD DIFASAVQFL
460
KFHDRKRNQK SS
Length:462
Mass (Da):52,612
Last modified:November 1, 1996 - v1
Checksum:i667D1A66C2EE430B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46682 mRNA Translation: AAC47018.1
PIRiJC4686

Similar proteinsi

Entry informationi

Entry nameiHYEP_MANSE
AccessioniPrimary (citable) accession number: Q25489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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Main funding by: National Institutes of Health