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Protein

Juvenile hormone epoxide hydrolase

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes juvenile hormone hydrolysis.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Protein family/group databases

ESTHERimanse-hyep. Epoxide_hydrolase.
MEROPSiS33.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Juvenile hormone epoxide hydrolase (EC:3.3.2.9)
Short name:
JHEH
Alternative name(s):
Juvenile hormone-specific epoxide hydrolase
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2423Helical; Signal-anchorSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Juvenile hormone epoxide hydrolasePRO_0000080862Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ25489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q25489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKILSSFVA GVAIGSGLVI TYVLYNVPEP PELDLQRWWG IGTRPTEEDK
60 70 80 90 100
SIRPFSIDFN DTVILDLKER LKNRRPFTKP LEGINSEYGM NTEYLETVLE
110 120 130 140 150
YWLNEYNFKK RAELLNKFPH YKTRIQGLDL HFIRVKPEIK EGVQVLPLLM
160 170 180 190 200
MHGWPSSSKE FDKVIPILTT PKHEYNIVFE VVAVDLPGYG FSEGTNKPGL
210 220 230 240 250
NPVQIGVMMR NLMLRLGFEK FYIQAGDWGS QCATHMATLF PDQVLGLHTN
260 270 280 290 300
MPLSSRPLST VKLFIGALFP SLIVDAKYMD RIYPLKNLFS YILRETGYFH
310 320 330 340 350
IQATKPDTIG VALTDSPAGL AGYLIEKMAI CSNRDQLDTP HGGLENLNLD
360 370 380 390 400
DVLDTVTINW INNCIVTSTR LYAEGFSWPE VLIVHRIPSM VPTAGINFKY
410 420 430 440 450
EVLYQPDWIL RDKFPNLVRS TVLDFGGHFA ALHTPQALAD DIFASAVQFL
460
KFHDRKRNQK SS
Length:462
Mass (Da):52,612
Last modified:November 1, 1996 - v1
Checksum:i667D1A66C2EE430B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46682 mRNA. Translation: AAC47018.1.
PIRiJC4686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46682 mRNA. Translation: AAC47018.1.
PIRiJC4686.

3D structure databases

ProteinModelPortaliQ25489.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERimanse-hyep. Epoxide_hydrolase.
MEROPSiS33.971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "An insect juvenile hormone-specific epoxide hydrolase is related to vertebrate microsomal epoxide hydrolases."
    Wojtasek H., Prestwich G.D.
    Biochem. Biophys. Res. Commun. 220:323-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 91-110 AND 237-250.
    Tissue: Egg.

Entry informationi

Entry nameiHYEP_MANSE
AccessioniPrimary (citable) accession number: Q25489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.