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Q25489

- HYEP_MANSE

UniProt

Q25489 - HYEP_MANSE

Protein

Juvenile hormone epoxide hydrolase

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes juvenile hormone hydrolysis.By similarity

    Catalytic activityi

    Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

    GO - Molecular functioni

    1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Juvenile hormone epoxide hydrolase (EC:3.3.2.9)
    Short name:
    JHEH
    Alternative name(s):
    Juvenile hormone-specific epoxide hydrolase
    OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
    Taxonomic identifieri7130 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Juvenile hormone epoxide hydrolasePRO_0000080862Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ25489.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2423Helical; Signal-anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S33 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    IPR010497. Epoxide_hydro_N.
    IPR016292. Epoxide_hydrolase.
    [Graphical view]
    PfamiPF00561. Abhydrolase_1. 1 hit.
    PF06441. EHN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
    PRINTSiPR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q25489-1 [UniParc]FASTAAdd to Basket

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    MYKILSSFVA GVAIGSGLVI TYVLYNVPEP PELDLQRWWG IGTRPTEEDK    50
    SIRPFSIDFN DTVILDLKER LKNRRPFTKP LEGINSEYGM NTEYLETVLE 100
    YWLNEYNFKK RAELLNKFPH YKTRIQGLDL HFIRVKPEIK EGVQVLPLLM 150
    MHGWPSSSKE FDKVIPILTT PKHEYNIVFE VVAVDLPGYG FSEGTNKPGL 200
    NPVQIGVMMR NLMLRLGFEK FYIQAGDWGS QCATHMATLF PDQVLGLHTN 250
    MPLSSRPLST VKLFIGALFP SLIVDAKYMD RIYPLKNLFS YILRETGYFH 300
    IQATKPDTIG VALTDSPAGL AGYLIEKMAI CSNRDQLDTP HGGLENLNLD 350
    DVLDTVTINW INNCIVTSTR LYAEGFSWPE VLIVHRIPSM VPTAGINFKY 400
    EVLYQPDWIL RDKFPNLVRS TVLDFGGHFA ALHTPQALAD DIFASAVQFL 450
    KFHDRKRNQK SS 462
    Length:462
    Mass (Da):52,612
    Last modified:November 1, 1996 - v1
    Checksum:i667D1A66C2EE430B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46682 mRNA. Translation: AAC47018.1.
    PIRiJC4686.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46682 mRNA. Translation: AAC47018.1 .
    PIRi JC4686.

    3D structure databases

    ProteinModelPortali Q25489.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    IPR010497. Epoxide_hydro_N.
    IPR016292. Epoxide_hydrolase.
    [Graphical view ]
    Pfami PF00561. Abhydrolase_1. 1 hit.
    PF06441. EHN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
    PRINTSi PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "An insect juvenile hormone-specific epoxide hydrolase is related to vertebrate microsomal epoxide hydrolases."
      Wojtasek H., Prestwich G.D.
      Biochem. Biophys. Res. Commun. 220:323-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 91-110 AND 237-250.
      Tissue: Egg.

    Entry informationi

    Entry nameiHYEP_MANSE
    AccessioniPrimary (citable) accession number: Q25489
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3