SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q25489

- HYEP_MANSE

UniProt

Q25489 - HYEP_MANSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Juvenile hormone epoxide hydrolase
Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes juvenile hormone hydrolysis By similarity.

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

GO - Molecular functioni

  1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Juvenile hormone epoxide hydrolase (EC:3.3.2.9)
Short name:
JHEH
Alternative name(s):
Juvenile hormone-specific epoxide hydrolase
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2423Helical; Signal-anchor; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Juvenile hormone epoxide hydrolase
PRO_0000080862Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ25489.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q25489-1 [UniParc]FASTAAdd to Basket

« Hide

MYKILSSFVA GVAIGSGLVI TYVLYNVPEP PELDLQRWWG IGTRPTEEDK    50
SIRPFSIDFN DTVILDLKER LKNRRPFTKP LEGINSEYGM NTEYLETVLE 100
YWLNEYNFKK RAELLNKFPH YKTRIQGLDL HFIRVKPEIK EGVQVLPLLM 150
MHGWPSSSKE FDKVIPILTT PKHEYNIVFE VVAVDLPGYG FSEGTNKPGL 200
NPVQIGVMMR NLMLRLGFEK FYIQAGDWGS QCATHMATLF PDQVLGLHTN 250
MPLSSRPLST VKLFIGALFP SLIVDAKYMD RIYPLKNLFS YILRETGYFH 300
IQATKPDTIG VALTDSPAGL AGYLIEKMAI CSNRDQLDTP HGGLENLNLD 350
DVLDTVTINW INNCIVTSTR LYAEGFSWPE VLIVHRIPSM VPTAGINFKY 400
EVLYQPDWIL RDKFPNLVRS TVLDFGGHFA ALHTPQALAD DIFASAVQFL 450
KFHDRKRNQK SS 462
Length:462
Mass (Da):52,612
Last modified:November 1, 1996 - v1
Checksum:i667D1A66C2EE430B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46682 mRNA. Translation: AAC47018.1.
PIRiJC4686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46682 mRNA. Translation: AAC47018.1 .
PIRi JC4686.

3D structure databases

ProteinModelPortali Q25489.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSi PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "An insect juvenile hormone-specific epoxide hydrolase is related to vertebrate microsomal epoxide hydrolases."
    Wojtasek H., Prestwich G.D.
    Biochem. Biophys. Res. Commun. 220:323-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 91-110 AND 237-250.
    Tissue: Egg.

Entry informationi

Entry nameiHYEP_MANSE
AccessioniPrimary (citable) accession number: Q25489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi