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Q25464 (FP2_MYTGA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adhesive plaque matrix protein 2
Alternative name(s):
Foot protein 2
MGFP-2
Short name=MGFP2
Gene names
Name:FP2
OrganismMytilus galloprovincialis (Mediterranean mussel)
Taxonomic identifier29158 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Provides adhesiveness to the mussel's foot. Mussels produce one of the strongest water insoluble glues. The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins.

Subcellular location

Secreted.

Tissue specificity

Produced by the byssal gland.

Developmental stage

Expression starts at the pediveliger, foot formation, stage.

Post-translational modification

Contains L-DOPA (3',4'-dihydroxyphenylalanine) By similarity.

Sequence similarities

Contains 11 EGF-like domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainEGF-like domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
Hydroxylation
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 473456Adhesive plaque matrix protein 2
PRO_0000007588

Regions

Domain45 – 8137EGF-like 1
Domain82 – 11736EGF-like 2
Domain118 – 15437EGF-like 3
Domain155 – 19137EGF-like 4
Domain192 – 22837EGF-like 5
Domain229 – 26537EGF-like 6
Domain266 – 30136EGF-like 7
Domain302 – 34039EGF-like 8
Domain342 – 37837EGF-like 9
Domain383 – 42038EGF-like 10
Domain425 – 46137EGF-like 11

Amino acid modifications

Modified residue2313',4'-dihydroxyphenylalanine By similarity
Modified residue3113',4'-dihydroxyphenylalanine By similarity
Modified residue3613',4'-dihydroxyphenylalanine By similarity
Modified residue4313',4'-dihydroxyphenylalanine By similarity
Glycosylation931N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 60 By similarity
Disulfide bond54 ↔ 69 By similarity
Disulfide bond71 ↔ 80 By similarity
Disulfide bond86 ↔ 97 By similarity
Disulfide bond91 ↔ 106 By similarity
Disulfide bond108 ↔ 117 By similarity
Disulfide bond122 ↔ 133 By similarity
Disulfide bond127 ↔ 143 By similarity
Disulfide bond145 ↔ 154 By similarity
Disulfide bond159 ↔ 170 By similarity
Disulfide bond164 ↔ 180 By similarity
Disulfide bond182 ↔ 191 By similarity
Disulfide bond196 ↔ 207 By similarity
Disulfide bond201 ↔ 217 By similarity
Disulfide bond219 ↔ 228 By similarity
Disulfide bond233 ↔ 244 By similarity
Disulfide bond238 ↔ 254 By similarity
Disulfide bond256 ↔ 265 By similarity
Disulfide bond270 ↔ 281 By similarity
Disulfide bond275 ↔ 290 By similarity
Disulfide bond292 ↔ 301 By similarity
Disulfide bond306 ↔ 317 By similarity
Disulfide bond311 ↔ 328 By similarity
Disulfide bond330 ↔ 339 By similarity
Disulfide bond346 ↔ 357 By similarity
Disulfide bond351 ↔ 366 By similarity
Disulfide bond368 ↔ 377 By similarity
Disulfide bond387 ↔ 399 By similarity
Disulfide bond393 ↔ 408 By similarity
Disulfide bond410 ↔ 419 By similarity
Disulfide bond429 ↔ 440 By similarity
Disulfide bond434 ↔ 449 By similarity
Disulfide bond451 ↔ 460 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q25464 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BA76BA8C3BA49A0F

FASTA47351,772
        10         20         30         40         50         60 
MLFSFFLLLT CTQLCLGTNR PDYNDDEEDD YKPPVYKPSP SKYRPVNPCL KKPCKYNGVC 

        70         80         90        100        110        120 
KPRGGSYKCF CKGGYYGYNC NLKNACKPNQ CKNKSRCVPV GKTFKCVCRN GNFGRLCEKN 

       130        140        150        160        170        180 
VCSPNPCKNN GKCSPLGKTG YKCTCSGGYT GPRCEVHACK PNPCKNKGRC FPDGKTGYKC 

       190        200        210        220        230        240 
RCVDGYSGPT CQENACKPNP CSNGGTCSAD KFGDYSCECR PGYFGPECER YVCAPNPCKN 

       250        260        270        280        290        300 
GGICSSDGSG GYRCRCKGGY SGPTCKVNVC KPTPCKNSGR CVNKGSSYNC ICKGGYSGPT 

       310        320        330        340        350        360 
CGENVCKPNP CQNRGRCYPD NSDDGFKCRC VGGYKGPTCE DKPNPCNTKP CKNGGKCNYN 

       370        380        390        400        410        420 
GKIYTCKCAY GWRGRHCTDK AYKPNPCVVS KPCKNRGKCI WNGKAYRCKC AYGYGGRHCT 

       430        440        450        460        470 
KKSYKKNPCA SRPCKNRGKC TDKGNGYVCK CARGYSGRYC SLKSPPSYDD DEY 

« Hide

References

[1]"Mussel adhesive plaque protein gene is a novel member of epidermal growth factor-like gene family."
Inoue K., Takeuchi Y., Miki D., Odo S.
J. Biol. Chem. 270:6698-6701(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Foot.

Web resources

Protein Spotlight

Sticky business - Issue 2 of September 2001

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D43794 mRNA. Translation: BAA07852.1.
PIRA56175.

3D structure databases

ProteinModelPortalQ25464.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
[Graphical view]
PfamPF00008. EGF. 5 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 11 hits.
[Graphical view]
PROSITEPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 11 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 11 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFP2_MYTGA
AccessionPrimary (citable) accession number: Q25464
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries