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Q25464

- FP2_MYTGA

UniProt

Q25464 - FP2_MYTGA

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Protein

Adhesive plaque matrix protein 2

Gene
FP2
Organism
Mytilus galloprovincialis (Mediterranean mussel)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Provides adhesiveness to the mussel's foot. Mussels produce one of the strongest water insoluble glues. The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesive plaque matrix protein 2
Alternative name(s):
Foot protein 2
MGFP-2
Short name:
MGFP2
Gene namesi
Name:FP2
OrganismiMytilus galloprovincialis (Mediterranean mussel)
Taxonomic identifieri29158 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 473456Adhesive plaque matrix protein 2PRO_0000007588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 2313',4'-dihydroxyphenylalanine By similarity
Modified residuei31 – 3113',4'-dihydroxyphenylalanine By similarity
Modified residuei36 – 3613',4'-dihydroxyphenylalanine By similarity
Modified residuei43 – 4313',4'-dihydroxyphenylalanine By similarity
Disulfide bondi49 ↔ 60 By similarity
Disulfide bondi54 ↔ 69 By similarity
Disulfide bondi71 ↔ 80 By similarity
Disulfide bondi86 ↔ 97 By similarity
Disulfide bondi91 ↔ 106 By similarity
Glycosylationi93 – 931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi108 ↔ 117 By similarity
Disulfide bondi122 ↔ 133 By similarity
Disulfide bondi127 ↔ 143 By similarity
Disulfide bondi145 ↔ 154 By similarity
Disulfide bondi159 ↔ 170 By similarity
Disulfide bondi164 ↔ 180 By similarity
Disulfide bondi182 ↔ 191 By similarity
Disulfide bondi196 ↔ 207 By similarity
Disulfide bondi201 ↔ 217 By similarity
Disulfide bondi219 ↔ 228 By similarity
Disulfide bondi233 ↔ 244 By similarity
Disulfide bondi238 ↔ 254 By similarity
Disulfide bondi256 ↔ 265 By similarity
Disulfide bondi270 ↔ 281 By similarity
Disulfide bondi275 ↔ 290 By similarity
Disulfide bondi292 ↔ 301 By similarity
Disulfide bondi306 ↔ 317 By similarity
Disulfide bondi311 ↔ 328 By similarity
Disulfide bondi330 ↔ 339 By similarity
Disulfide bondi346 ↔ 357 By similarity
Disulfide bondi351 ↔ 366 By similarity
Disulfide bondi368 ↔ 377 By similarity
Disulfide bondi387 ↔ 399 By similarity
Disulfide bondi393 ↔ 408 By similarity
Disulfide bondi410 ↔ 419 By similarity
Disulfide bondi429 ↔ 440 By similarity
Disulfide bondi434 ↔ 449 By similarity
Disulfide bondi451 ↔ 460 By similarity

Post-translational modificationi

Contains L-DOPA (3',4'-dihydroxyphenylalanine) By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Expressioni

Tissue specificityi

Produced by the byssal gland.

Developmental stagei

Expression starts at the pediveliger, foot formation, stage.

Structurei

3D structure databases

ProteinModelPortaliQ25464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 8137EGF-like 1Add
BLAST
Domaini82 – 11736EGF-like 2Add
BLAST
Domaini118 – 15437EGF-like 3Add
BLAST
Domaini155 – 19137EGF-like 4Add
BLAST
Domaini192 – 22837EGF-like 5Add
BLAST
Domaini229 – 26537EGF-like 6Add
BLAST
Domaini266 – 30136EGF-like 7Add
BLAST
Domaini302 – 34039EGF-like 8Add
BLAST
Domaini342 – 37837EGF-like 9Add
BLAST
Domaini383 – 42038EGF-like 10Add
BLAST
Domaini425 – 46137EGF-like 11Add
BLAST

Sequence similaritiesi

Contains 11 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
[Graphical view]
PfamiPF00008. EGF. 5 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 11 hits.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 11 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q25464-1 [UniParc]FASTAAdd to Basket

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MLFSFFLLLT CTQLCLGTNR PDYNDDEEDD YKPPVYKPSP SKYRPVNPCL    50
KKPCKYNGVC KPRGGSYKCF CKGGYYGYNC NLKNACKPNQ CKNKSRCVPV 100
GKTFKCVCRN GNFGRLCEKN VCSPNPCKNN GKCSPLGKTG YKCTCSGGYT 150
GPRCEVHACK PNPCKNKGRC FPDGKTGYKC RCVDGYSGPT CQENACKPNP 200
CSNGGTCSAD KFGDYSCECR PGYFGPECER YVCAPNPCKN GGICSSDGSG 250
GYRCRCKGGY SGPTCKVNVC KPTPCKNSGR CVNKGSSYNC ICKGGYSGPT 300
CGENVCKPNP CQNRGRCYPD NSDDGFKCRC VGGYKGPTCE DKPNPCNTKP 350
CKNGGKCNYN GKIYTCKCAY GWRGRHCTDK AYKPNPCVVS KPCKNRGKCI 400
WNGKAYRCKC AYGYGGRHCT KKSYKKNPCA SRPCKNRGKC TDKGNGYVCK 450
CARGYSGRYC SLKSPPSYDD DEY 473
Length:473
Mass (Da):51,772
Last modified:November 1, 1996 - v1
Checksum:iBA76BA8C3BA49A0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43794 mRNA. Translation: BAA07852.1.
PIRiA56175.

Cross-referencesi

Web resourcesi

Protein Spotlight

Sticky business - Issue 2 of September 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43794 mRNA. Translation: BAA07852.1 .
PIRi A56175.

3D structure databases

ProteinModelPortali Q25464.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
[Graphical view ]
Pfami PF00008. EGF. 5 hits.
PF12661. hEGF. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 11 hits.
[Graphical view ]
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 11 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mussel adhesive plaque protein gene is a novel member of epidermal growth factor-like gene family."
    Inoue K., Takeuchi Y., Miki D., Odo S.
    J. Biol. Chem. 270:6698-6701(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Foot.

Entry informationi

Entry nameiFP2_MYTGA
AccessioniPrimary (citable) accession number: Q25464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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