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Q25464

- FP2_MYTGA

UniProt

Q25464 - FP2_MYTGA

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Protein

Adhesive plaque matrix protein 2

Gene

FP2

Organism
Mytilus galloprovincialis (Mediterranean mussel)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Provides adhesiveness to the mussel's foot. Mussels produce one of the strongest water insoluble glues. The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesive plaque matrix protein 2
Alternative name(s):
Foot protein 2
MGFP-2
Short name:
MGFP2
Gene namesi
Name:FP2
OrganismiMytilus galloprovincialis (Mediterranean mussel)
Taxonomic identifieri29158 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 473456Adhesive plaque matrix protein 2PRO_0000007588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 2313',4'-dihydroxyphenylalanineBy similarity
Modified residuei31 – 3113',4'-dihydroxyphenylalanineBy similarity
Modified residuei36 – 3613',4'-dihydroxyphenylalanineBy similarity
Modified residuei43 – 4313',4'-dihydroxyphenylalanineBy similarity
Disulfide bondi49 ↔ 60PROSITE-ProRule annotation
Disulfide bondi54 ↔ 69PROSITE-ProRule annotation
Disulfide bondi71 ↔ 80PROSITE-ProRule annotation
Disulfide bondi86 ↔ 97PROSITE-ProRule annotation
Disulfide bondi91 ↔ 106PROSITE-ProRule annotation
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi108 ↔ 117PROSITE-ProRule annotation
Disulfide bondi122 ↔ 133PROSITE-ProRule annotation
Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
Disulfide bondi159 ↔ 170PROSITE-ProRule annotation
Disulfide bondi164 ↔ 180PROSITE-ProRule annotation
Disulfide bondi182 ↔ 191PROSITE-ProRule annotation
Disulfide bondi196 ↔ 207PROSITE-ProRule annotation
Disulfide bondi201 ↔ 217PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi233 ↔ 244PROSITE-ProRule annotation
Disulfide bondi238 ↔ 254PROSITE-ProRule annotation
Disulfide bondi256 ↔ 265PROSITE-ProRule annotation
Disulfide bondi270 ↔ 281PROSITE-ProRule annotation
Disulfide bondi275 ↔ 290PROSITE-ProRule annotation
Disulfide bondi292 ↔ 301PROSITE-ProRule annotation
Disulfide bondi306 ↔ 317PROSITE-ProRule annotation
Disulfide bondi311 ↔ 328PROSITE-ProRule annotation
Disulfide bondi330 ↔ 339PROSITE-ProRule annotation
Disulfide bondi346 ↔ 357PROSITE-ProRule annotation
Disulfide bondi351 ↔ 366PROSITE-ProRule annotation
Disulfide bondi368 ↔ 377PROSITE-ProRule annotation
Disulfide bondi387 ↔ 399PROSITE-ProRule annotation
Disulfide bondi393 ↔ 408PROSITE-ProRule annotation
Disulfide bondi410 ↔ 419PROSITE-ProRule annotation
Disulfide bondi429 ↔ 440PROSITE-ProRule annotation
Disulfide bondi434 ↔ 449PROSITE-ProRule annotation
Disulfide bondi451 ↔ 460PROSITE-ProRule annotation

Post-translational modificationi

Contains L-DOPA (3',4'-dihydroxyphenylalanine).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Expressioni

Tissue specificityi

Produced by the byssal gland.

Developmental stagei

Expression starts at the pediveliger, foot formation, stage.

Structurei

3D structure databases

ProteinModelPortaliQ25464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 8137EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini82 – 11736EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini118 – 15437EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini155 – 19137EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini192 – 22837EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini229 – 26537EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 30136EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini302 – 34039EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini342 – 37837EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini383 – 42038EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini425 – 46137EGF-like 11PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
[Graphical view]
PfamiPF00008. EGF. 5 hits.
PF12661. hEGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 11 hits.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 11 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q25464-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLFSFFLLLT CTQLCLGTNR PDYNDDEEDD YKPPVYKPSP SKYRPVNPCL
60 70 80 90 100
KKPCKYNGVC KPRGGSYKCF CKGGYYGYNC NLKNACKPNQ CKNKSRCVPV
110 120 130 140 150
GKTFKCVCRN GNFGRLCEKN VCSPNPCKNN GKCSPLGKTG YKCTCSGGYT
160 170 180 190 200
GPRCEVHACK PNPCKNKGRC FPDGKTGYKC RCVDGYSGPT CQENACKPNP
210 220 230 240 250
CSNGGTCSAD KFGDYSCECR PGYFGPECER YVCAPNPCKN GGICSSDGSG
260 270 280 290 300
GYRCRCKGGY SGPTCKVNVC KPTPCKNSGR CVNKGSSYNC ICKGGYSGPT
310 320 330 340 350
CGENVCKPNP CQNRGRCYPD NSDDGFKCRC VGGYKGPTCE DKPNPCNTKP
360 370 380 390 400
CKNGGKCNYN GKIYTCKCAY GWRGRHCTDK AYKPNPCVVS KPCKNRGKCI
410 420 430 440 450
WNGKAYRCKC AYGYGGRHCT KKSYKKNPCA SRPCKNRGKC TDKGNGYVCK
460 470
CARGYSGRYC SLKSPPSYDD DEY
Length:473
Mass (Da):51,772
Last modified:November 1, 1996 - v1
Checksum:iBA76BA8C3BA49A0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43794 mRNA. Translation: BAA07852.1.
PIRiA56175.

Cross-referencesi

Web resourcesi

Protein Spotlight

Sticky business - Issue 2 of September 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43794 mRNA. Translation: BAA07852.1 .
PIRi A56175.

3D structure databases

ProteinModelPortali Q25464.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
[Graphical view ]
Pfami PF00008. EGF. 5 hits.
PF12661. hEGF. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 11 hits.
[Graphical view ]
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 11 hits.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mussel adhesive plaque protein gene is a novel member of epidermal growth factor-like gene family."
    Inoue K., Takeuchi Y., Miki D., Odo S.
    J. Biol. Chem. 270:6698-6701(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Foot.

Entry informationi

Entry nameiFP2_MYTGA
AccessioniPrimary (citable) accession number: Q25464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3