Reviewed, UniProtKB/Swiss-Prot Q25464 (FP2_MYTGA)

Names and origin

Protein names

Recommended name:
    Adhesive plaque matrix protein 2
Alternative name(s):
    Foot protein 2
    MGFP-2
      Short name=MGFP2

Gene names

Name:

FP2

Organism

Mytilus galloprovincialis (Mediterranean mussel)

Taxonomic identifier

29158 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Mollusca › Bivalvia › Pteriomorphia › Mytiloida › Mytiloidea › Mytilidae › Mytilinae › Mytilus

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Provides adhesiveness to the mussel's foot. Mussels produce one of the strongest water insoluble glue. The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins.
Subcellular location	Secreted.
Tissue specificity	Produced by the byssal gland.
Developmental stage	Expression starts at the pediveliger, foot formation, stage.
Post-translational modification	Contains L-DOPA (3',4'-dihydroxyphenylalanine) By similarity.
Sequence similarities	Contains 11 EGF-like domains.

Ontologies

Keywords
Cellular component	Secreted
Domain	EGF-like domain Repeat Signal
PTM	Disulfide bond Glycoprotein Hydroxylation
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 473	456	Adhesive plaque matrix protein 2		PRO_0000007588
Regions
	Domain	45 – 81	37	EGF-like 1
	Domain	82 – 117	36	EGF-like 2
	Domain	118 – 154	37	EGF-like 3
	Domain	155 – 191	37	EGF-like 4
	Domain	192 – 228	37	EGF-like 5
	Domain	229 – 265	37	EGF-like 6
	Domain	266 – 301	36	EGF-like 7
	Domain	302 – 340	39	EGF-like 8
	Domain	342 – 378	37	EGF-like 9
	Domain	383 – 420	38	EGF-like 10
	Domain	425 – 461	37	EGF-like 11
Amino acid modifications
	Modified residue	23	1	3',4'-dihydroxyphenylalanine By similarity
	Modified residue	31	1	3',4'-dihydroxyphenylalanine By similarity
	Modified residue	36	1	3',4'-dihydroxyphenylalanine By similarity
	Modified residue	43	1	3',4'-dihydroxyphenylalanine By similarity
	Glycosylation	93	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 60		By similarity
	Disulfide bond	54 ↔ 69		By similarity
	Disulfide bond	71 ↔ 80		By similarity
	Disulfide bond	86 ↔ 97		By similarity
	Disulfide bond	91 ↔ 106		By similarity
	Disulfide bond	108 ↔ 117		By similarity
	Disulfide bond	122 ↔ 133		By similarity
	Disulfide bond	127 ↔ 143		By similarity
	Disulfide bond	145 ↔ 154		By similarity
	Disulfide bond	159 ↔ 170		By similarity
	Disulfide bond	164 ↔ 180		By similarity
	Disulfide bond	182 ↔ 191		By similarity
	Disulfide bond	196 ↔ 207		By similarity
	Disulfide bond	201 ↔ 217		By similarity
	Disulfide bond	219 ↔ 228		By similarity
	Disulfide bond	233 ↔ 244		By similarity
	Disulfide bond	238 ↔ 254		By similarity
	Disulfide bond	256 ↔ 265		By similarity
	Disulfide bond	270 ↔ 281		By similarity
	Disulfide bond	275 ↔ 290		By similarity
	Disulfide bond	292 ↔ 301		By similarity
	Disulfide bond	306 ↔ 317		By similarity
	Disulfide bond	311 ↔ 328		By similarity
	Disulfide bond	330 ↔ 339		By similarity
	Disulfide bond	346 ↔ 357		By similarity
	Disulfide bond	351 ↔ 366		By similarity
	Disulfide bond	368 ↔ 377		By similarity
	Disulfide bond	387 ↔ 399		By similarity
	Disulfide bond	393 ↔ 408		By similarity
	Disulfide bond	410 ↔ 419		By similarity
	Disulfide bond	429 ↔ 440		By similarity
	Disulfide bond	434 ↔ 449		By similarity
	Disulfide bond	451 ↔ 460		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q25464-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BA76BA8C3BA49A0F	FASTA	473	51,772
	10 20 30 40 50 60 MLFSFFLLLT CTQLCLGTNR PDYNDDEEDD YKPPVYKPSP SKYRPVNPCL KKPCKYNGVC 70 80 90 100 110 120 KPRGGSYKCF CKGGYYGYNC NLKNACKPNQ CKNKSRCVPV GKTFKCVCRN GNFGRLCEKN 130 140 150 160 170 180 VCSPNPCKNN GKCSPLGKTG YKCTCSGGYT GPRCEVHACK PNPCKNKGRC FPDGKTGYKC 190 200 210 220 230 240 RCVDGYSGPT CQENACKPNP CSNGGTCSAD KFGDYSCECR PGYFGPECER YVCAPNPCKN 250 260 270 280 290 300 GGICSSDGSG GYRCRCKGGY SGPTCKVNVC KPTPCKNSGR CVNKGSSYNC ICKGGYSGPT 310 320 330 340 350 360 CGENVCKPNP CQNRGRCYPD NSDDGFKCRC VGGYKGPTCE DKPNPCNTKP CKNGGKCNYN 370 380 390 400 410 420 GKIYTCKCAY GWRGRHCTDK AYKPNPCVVS KPCKNRGKCI WNGKAYRCKC AYGYGGRHCT 430 440 450 460 470 KKSYKKNPCA SRPCKNRGKC TDKGNGYVCK CARGYSGRYC SLKSPPSYDD DEY

References

[1]	"Mussel adhesive plaque protein gene is a novel member of epidermal growth factor-like gene family." Inoue K., Takeuchi Y., Miki D., Odo S. J. Biol. Chem. 270:6698-6701(1995) [PubMed: 7896812] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Foot.

Web resources

Protein Spotlight

Sticky business - Issue 2 of September 2001

Cross-references

Sequence databases
EMBLGenBankDDBJ	D43794 mRNA. Translation: BAA07852.1.
PIR	A56175.
3D structure databases
HSSP	HSSP built from PDB template 1EDM based on UniProtKB P00740.
ModBase	Search...
Family and domain databases
InterPro	IPR006209. EGF. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. [Graphical view]
Pfam	PF00008. EGF. 11 hits. [Graphical view]
SMART	SM00181. EGF. 11 hits. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 2 hits. PS00022. EGF_1. 11 hits. PS01186. EGF_2. 10 hits. PS50026. EGF_3. 11 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FP2_MYTGA

Accession

Primary (citable) accession number: Q25464

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	September 22, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)