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Q25464

- FP2_MYTGA

UniProt

Q25464 - FP2_MYTGA

Protein

Adhesive plaque matrix protein 2

Gene

FP2

Organism
Mytilus galloprovincialis (Mediterranean mussel)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Provides adhesiveness to the mussel's foot. Mussels produce one of the strongest water insoluble glues. The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adhesive plaque matrix protein 2
    Alternative name(s):
    Foot protein 2
    MGFP-2
    Short name:
    MGFP2
    Gene namesi
    Name:FP2
    OrganismiMytilus galloprovincialis (Mediterranean mussel)
    Taxonomic identifieri29158 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 473456Adhesive plaque matrix protein 2PRO_0000007588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 2313',4'-dihydroxyphenylalanineBy similarity
    Modified residuei31 – 3113',4'-dihydroxyphenylalanineBy similarity
    Modified residuei36 – 3613',4'-dihydroxyphenylalanineBy similarity
    Modified residuei43 – 4313',4'-dihydroxyphenylalanineBy similarity
    Disulfide bondi49 ↔ 60PROSITE-ProRule annotation
    Disulfide bondi54 ↔ 69PROSITE-ProRule annotation
    Disulfide bondi71 ↔ 80PROSITE-ProRule annotation
    Disulfide bondi86 ↔ 97PROSITE-ProRule annotation
    Disulfide bondi91 ↔ 106PROSITE-ProRule annotation
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 117PROSITE-ProRule annotation
    Disulfide bondi122 ↔ 133PROSITE-ProRule annotation
    Disulfide bondi127 ↔ 143PROSITE-ProRule annotation
    Disulfide bondi145 ↔ 154PROSITE-ProRule annotation
    Disulfide bondi159 ↔ 170PROSITE-ProRule annotation
    Disulfide bondi164 ↔ 180PROSITE-ProRule annotation
    Disulfide bondi182 ↔ 191PROSITE-ProRule annotation
    Disulfide bondi196 ↔ 207PROSITE-ProRule annotation
    Disulfide bondi201 ↔ 217PROSITE-ProRule annotation
    Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
    Disulfide bondi233 ↔ 244PROSITE-ProRule annotation
    Disulfide bondi238 ↔ 254PROSITE-ProRule annotation
    Disulfide bondi256 ↔ 265PROSITE-ProRule annotation
    Disulfide bondi270 ↔ 281PROSITE-ProRule annotation
    Disulfide bondi275 ↔ 290PROSITE-ProRule annotation
    Disulfide bondi292 ↔ 301PROSITE-ProRule annotation
    Disulfide bondi306 ↔ 317PROSITE-ProRule annotation
    Disulfide bondi311 ↔ 328PROSITE-ProRule annotation
    Disulfide bondi330 ↔ 339PROSITE-ProRule annotation
    Disulfide bondi346 ↔ 357PROSITE-ProRule annotation
    Disulfide bondi351 ↔ 366PROSITE-ProRule annotation
    Disulfide bondi368 ↔ 377PROSITE-ProRule annotation
    Disulfide bondi387 ↔ 399PROSITE-ProRule annotation
    Disulfide bondi393 ↔ 408PROSITE-ProRule annotation
    Disulfide bondi410 ↔ 419PROSITE-ProRule annotation
    Disulfide bondi429 ↔ 440PROSITE-ProRule annotation
    Disulfide bondi434 ↔ 449PROSITE-ProRule annotation
    Disulfide bondi451 ↔ 460PROSITE-ProRule annotation

    Post-translational modificationi

    Contains L-DOPA (3',4'-dihydroxyphenylalanine).By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Expressioni

    Tissue specificityi

    Produced by the byssal gland.

    Developmental stagei

    Expression starts at the pediveliger, foot formation, stage.

    Structurei

    3D structure databases

    ProteinModelPortaliQ25464.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 8137EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini82 – 11736EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini118 – 15437EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini155 – 19137EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini192 – 22837EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini229 – 26537EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini266 – 30136EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini302 – 34039EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini342 – 37837EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini383 – 42038EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini425 – 46137EGF-like 11PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 11 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    [Graphical view]
    PfamiPF00008. EGF. 5 hits.
    PF12661. hEGF. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 11 hits.
    [Graphical view]
    PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
    PS00022. EGF_1. 11 hits.
    PS01186. EGF_2. 10 hits.
    PS50026. EGF_3. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q25464-1 [UniParc]FASTAAdd to Basket

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    MLFSFFLLLT CTQLCLGTNR PDYNDDEEDD YKPPVYKPSP SKYRPVNPCL    50
    KKPCKYNGVC KPRGGSYKCF CKGGYYGYNC NLKNACKPNQ CKNKSRCVPV 100
    GKTFKCVCRN GNFGRLCEKN VCSPNPCKNN GKCSPLGKTG YKCTCSGGYT 150
    GPRCEVHACK PNPCKNKGRC FPDGKTGYKC RCVDGYSGPT CQENACKPNP 200
    CSNGGTCSAD KFGDYSCECR PGYFGPECER YVCAPNPCKN GGICSSDGSG 250
    GYRCRCKGGY SGPTCKVNVC KPTPCKNSGR CVNKGSSYNC ICKGGYSGPT 300
    CGENVCKPNP CQNRGRCYPD NSDDGFKCRC VGGYKGPTCE DKPNPCNTKP 350
    CKNGGKCNYN GKIYTCKCAY GWRGRHCTDK AYKPNPCVVS KPCKNRGKCI 400
    WNGKAYRCKC AYGYGGRHCT KKSYKKNPCA SRPCKNRGKC TDKGNGYVCK 450
    CARGYSGRYC SLKSPPSYDD DEY 473
    Length:473
    Mass (Da):51,772
    Last modified:November 1, 1996 - v1
    Checksum:iBA76BA8C3BA49A0F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43794 mRNA. Translation: BAA07852.1.
    PIRiA56175.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Sticky business - Issue 2 of September 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D43794 mRNA. Translation: BAA07852.1 .
    PIRi A56175.

    3D structure databases

    ProteinModelPortali Q25464.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    [Graphical view ]
    Pfami PF00008. EGF. 5 hits.
    PF12661. hEGF. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 11 hits.
    [Graphical view ]
    PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
    PS00022. EGF_1. 11 hits.
    PS01186. EGF_2. 10 hits.
    PS50026. EGF_3. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mussel adhesive plaque protein gene is a novel member of epidermal growth factor-like gene family."
      Inoue K., Takeuchi Y., Miki D., Odo S.
      J. Biol. Chem. 270:6698-6701(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Foot.

    Entry informationi

    Entry nameiFP2_MYTGA
    AccessioniPrimary (citable) accession number: Q25464
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3