Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q25460 (FP1_MYTED) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adhesive plaque matrix protein
Alternative name(s):
Foot protein 1
MEFP1
Polyphenolic adhesive protein
Gene names
Name:FP1
OrganismMytilus edulis (Blue mussel)
Taxonomic identifier6550 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Protein attributes

Sequence length875 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Provides adhesiveness to the mussel's foot. Mussels produce one of the strongest water insoluble glues. The mussel's adhesive is a bundle of threads, called a byssus, formed by a fibrous collagenous core coated with adhesive proteins.

Subcellular location

Secreted.

Tissue specificity

Produced by the byssal gland.

Domain

Almost exclusively composed of repeats of a decapeptide.

Post-translational modification

Hydroxylated on second and third proline and last tyrosine residues (to L-DOPA = 3',4'-dihydroxyphenylalanine) of the tandem repeats.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
   PTMHydroxylation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 875›875Adhesive plaque matrix protein
PRO_0000087326

Regions

Repeat75 – 84101
Repeat85 – 94102
Repeat95 – 10063; truncated
Repeat101 – 110104
Repeat111 – 120105
Repeat121 – 130106
Repeat131 – 140107
Repeat141 – 150108
Repeat151 – 160109
Repeat161 – 1701010
Repeat171 – 1801011
Repeat181 – 1901012
Repeat191 – 2001013
Repeat201 – 206614; truncated
Repeat207 – 2161015
Repeat217 – 2261016
Repeat227 – 232617; truncated
Repeat233 – 2421018
Repeat243 – 2521019
Repeat253 – 2621020
Repeat263 – 268621; truncated
Repeat269 – 274622; truncated
Repeat275 – 280623; truncated
Repeat281 – 2901024
Repeat291 – 3001025
Repeat301 – 3101026
Repeat311 – 3201027
Repeat321 – 3301028
Repeat331 – 3401029
Repeat341 – 346630; truncated
Repeat347 – 3561031
Repeat357 – 3661032
Repeat367 – 3761033
Repeat377 – 382634; truncated
Repeat383 – 3921035
Repeat393 – 4021036
Repeat403 – 4121037
Repeat413 – 418638
Repeat419 – 4281039
Repeat429 – 4381040
Repeat439 – 4481041
Repeat449 – 454642; truncated
Repeat455 – 4641043
Repeat465 – 4741044
Repeat475 – 4841045
Repeat485 – 4941046
Repeat495 – 5041047
Repeat505 – 5141048
Repeat515 – 5241049
Repeat525 – 5341050
Repeat535 – 5441051
Repeat545 – 5541052
Repeat555 – 5641053
Repeat565 – 5741054
Repeat575 – 5841055
Repeat585 – 590656; truncated
Repeat591 – 6001057
Repeat601 – 6101058
Repeat611 – 6201059
Repeat621 – 6301060
Repeat631 – 6401061
Repeat641 – 6501062
Repeat651 – 6601063
Repeat661 – 6701064
Repeat671 – 6801065
Repeat681 – 686666; truncated
Repeat687 – 6961067
Repeat697 – 7061068
Repeat707 – 7161069
Repeat717 – 7261070
Repeat727 – 732671; truncated
Repeat733 – 7421072
Repeat743 – 748673; truncated
Repeat749 – 7581074
Repeat759 – 7681075
Repeat769 – 7781076
Repeat779 – 7881077
Repeat789 – 7981078
Repeat799 – 8081079
Repeat809 – 8181080
Repeat819 – 8281081
Repeat829 – 8381082
Repeat839 – 8481083
Repeat849 – 8581084
Repeat859 – 8681085
Region75 – 86879485 X 10 AA tandem repeats of Y-[KN]-[PALKTS]-K-[LPMIKST]-[ST]-[YN]-[PK]-[PAS]-[STA]

Amino acid modifications

Modified residue8914-hydroxyproline; partial
Modified residue9113',4'-dihydroxyphenylalanine
Modified residue921(3R,4S)-3,4-dihydroxyproline
Modified residue9314-hydroxyproline
Modified residue9513',4'-dihydroxyphenylalanine
Modified residue11514-hydroxyproline; partial
Modified residue11713',4'-dihydroxyphenylalanine
Modified residue1181(3R,4S)-3,4-dihydroxyproline
Modified residue12113',4'-dihydroxyphenylalanine
Modified residue14514-hydroxyproline; partial
Modified residue14713',4'-dihydroxyphenylalanine
Modified residue1481(3R,4S)-3,4-dihydroxyproline
Modified residue14914-hydroxyproline
Modified residue15113',4'-dihydroxyphenylalanine
Modified residue15514-hydroxyproline; partial
Modified residue15713',4'-dihydroxyphenylalanine
Modified residue1581(3R,4S)-3,4-dihydroxyproline
Modified residue15914-hydroxyproline
Modified residue16113',4'-dihydroxyphenylalanine
Modified residue17514-hydroxyproline; partial
Modified residue17713',4'-dihydroxyphenylalanine
Modified residue1781(3R,4S)-3,4-dihydroxyproline
Modified residue17914-hydroxyproline
Modified residue18113',4'-dihydroxyphenylalanine
Modified residue18514-hydroxyproline; partial
Modified residue18713',4'-dihydroxyphenylalanine
Modified residue1881(3R,4S)-3,4-dihydroxyproline
Modified residue18914-hydroxyproline
Modified residue19113',4'-dihydroxyphenylalanine
Modified residue19514-hydroxyproline; partial
Modified residue19713',4'-dihydroxyphenylalanine
Modified residue1981(3R,4S)-3,4-dihydroxyproline
Modified residue19914-hydroxyproline
Modified residue20113',4'-dihydroxyphenylalanine
Modified residue21114-hydroxyproline; partial
Modified residue21313',4'-dihydroxyphenylalanine
Modified residue2141(3R,4S)-3,4-dihydroxyproline
Modified residue21713',4'-dihydroxyphenylalanine
Modified residue22114-hydroxyproline; partial
Modified residue22313',4'-dihydroxyphenylalanine
Modified residue2241(3R,4S)-3,4-dihydroxyproline
Modified residue22514-hydroxyproline
Modified residue22713',4'-dihydroxyphenylalanine
Modified residue23714-hydroxyproline; partial
Modified residue23913',4'-dihydroxyphenylalanine
Modified residue2401(3R,4S)-3,4-dihydroxyproline
Modified residue24114-hydroxyproline
Modified residue24313',4'-dihydroxyphenylalanine
Modified residue24714-hydroxyproline; partial
Modified residue24913',4'-dihydroxyphenylalanine
Modified residue2501(3R,4S)-3,4-dihydroxyproline
Modified residue25114-hydroxyproline
Modified residue25313',4'-dihydroxyphenylalanine
Modified residue25714-hydroxyproline; partial
Modified residue25913',4'-dihydroxyphenylalanine
Modified residue2601(3R,4S)-3,4-dihydroxyproline
Modified residue26114-hydroxyproline
Modified residue26313',4'-dihydroxyphenylalanine
Modified residue28514-hydroxyproline; partial
Modified residue28713',4'-dihydroxyphenylalanine
Modified residue2881(3R,4S)-3,4-dihydroxyproline
Modified residue28914-hydroxyproline
Modified residue29113',4'-dihydroxyphenylalanine
Modified residue29514-hydroxyproline; partial
Modified residue29713',4'-dihydroxyphenylalanine
Modified residue2981(3R,4S)-3,4-dihydroxyproline
Modified residue29914-hydroxyproline
Modified residue30113',4'-dihydroxyphenylalanine
Modified residue30514-hydroxyproline; partial
Modified residue30713',4'-dihydroxyphenylalanine
Modified residue3081(3R,4S)-3,4-dihydroxyproline
Modified residue30914-hydroxyproline
Modified residue31113',4'-dihydroxyphenylalanine
Modified residue31514-hydroxyproline; partial
Modified residue31713',4'-dihydroxyphenylalanine
Modified residue3181(3R,4S)-3,4-dihydroxyproline
Modified residue31914-hydroxyproline
Modified residue32113',4'-dihydroxyphenylalanine
Modified residue32514-hydroxyproline; partial
Modified residue32713',4'-dihydroxyphenylalanine
Modified residue3281(3R,4S)-3,4-dihydroxyproline
Modified residue32914-hydroxyproline
Modified residue33113',4'-dihydroxyphenylalanine
Modified residue33514-hydroxyproline; partial
Modified residue33713',4'-dihydroxyphenylalanine
Modified residue3381(3R,4S)-3,4-dihydroxyproline
Modified residue33914-hydroxyproline
Modified residue34113',4'-dihydroxyphenylalanine
Modified residue35114-hydroxyproline; partial
Modified residue35313',4'-dihydroxyphenylalanine
Modified residue3541(3R,4S)-3,4-dihydroxyproline
Modified residue35713',4'-dihydroxyphenylalanine
Modified residue36114-hydroxyproline; partial
Modified residue36313',4'-dihydroxyphenylalanine
Modified residue3641(3R,4S)-3,4-dihydroxyproline
Modified residue36514-hydroxyproline
Modified residue36713',4'-dihydroxyphenylalanine
Modified residue37114-hydroxyproline; partial
Modified residue37313',4'-dihydroxyphenylalanine
Modified residue3741(3R,4S)-3,4-dihydroxyproline
Modified residue37514-hydroxyproline
Modified residue37713',4'-dihydroxyphenylalanine
Modified residue38714-hydroxyproline; partial
Modified residue38913',4'-dihydroxyphenylalanine
Modified residue3901(3R,4S)-3,4-dihydroxyproline
Modified residue39114-hydroxyproline
Modified residue39313',4'-dihydroxyphenylalanine
Modified residue39714-hydroxyproline; partial
Modified residue39913',4'-dihydroxyphenylalanine
Modified residue4001(3R,4S)-3,4-dihydroxyproline
Modified residue40114-hydroxyproline
Modified residue40313',4'-dihydroxyphenylalanine
Modified residue40714-hydroxyproline; partial
Modified residue40913',4'-dihydroxyphenylalanine
Modified residue4101(3R,4S)-3,4-dihydroxyproline
Modified residue41114-hydroxyproline
Modified residue41313',4'-dihydroxyphenylalanine
Modified residue42314-hydroxyproline; partial
Modified residue42513',4'-dihydroxyphenylalanine
Modified residue4261(3R,4S)-3,4-dihydroxyproline
Modified residue42913',4'-dihydroxyphenylalanine
Modified residue43314-hydroxyproline; partial
Modified residue43513',4'-dihydroxyphenylalanine
Modified residue4361(3R,4S)-3,4-dihydroxyproline
Modified residue43714-hydroxyproline
Modified residue43913',4'-dihydroxyphenylalanine
Modified residue44314-hydroxyproline; partial
Modified residue44513',4'-dihydroxyphenylalanine
Modified residue4461(3R,4S)-3,4-dihydroxyproline
Modified residue44714-hydroxyproline
Modified residue44913',4'-dihydroxyphenylalanine
Modified residue45914-hydroxyproline; partial
Modified residue46113',4'-dihydroxyphenylalanine
Modified residue4621(3R,4S)-3,4-dihydroxyproline
Modified residue46513',4'-dihydroxyphenylalanine
Modified residue46914-hydroxyproline; partial
Modified residue47113',4'-dihydroxyphenylalanine
Modified residue4721(3R,4S)-3,4-dihydroxyproline
Modified residue47513',4'-dihydroxyphenylalanine
Modified residue47914-hydroxyproline; partial
Modified residue48113',4'-dihydroxyphenylalanine
Modified residue4821(3R,4S)-3,4-dihydroxyproline
Modified residue48314-hydroxyproline
Modified residue48513',4'-dihydroxyphenylalanine
Modified residue51914-hydroxyproline; partial
Modified residue52113',4'-dihydroxyphenylalanine
Modified residue5221(3R,4S)-3,4-dihydroxyproline
Modified residue52314-hydroxyproline
Modified residue52513',4'-dihydroxyphenylalanine
Modified residue54113',4'-dihydroxyphenylalanine
Modified residue5421(3R,4S)-3,4-dihydroxyproline
Modified residue54314-hydroxyproline
Modified residue54513',4'-dihydroxyphenylalanine
Modified residue54914-hydroxyproline; partial
Modified residue55113',4'-dihydroxyphenylalanine
Modified residue5521(3R,4S)-3,4-dihydroxyproline
Modified residue55513',4'-dihydroxyphenylalanine
Modified residue55914-hydroxyproline; partial
Modified residue56113',4'-dihydroxyphenylalanine
Modified residue5621(3R,4S)-3,4-dihydroxyproline
Modified residue56314-hydroxyproline
Modified residue56513',4'-dihydroxyphenylalanine
Modified residue56914-hydroxyproline; partial
Modified residue57113',4'-dihydroxyphenylalanine
Modified residue5721(3R,4S)-3,4-dihydroxyproline
Modified residue57314-hydroxyproline
Modified residue57513',4'-dihydroxyphenylalanine
Modified residue57914-hydroxyproline; partial
Modified residue58113',4'-dihydroxyphenylalanine
Modified residue5821(3R,4S)-3,4-dihydroxyproline
Modified residue58314-hydroxyproline
Modified residue58513',4'-dihydroxyphenylalanine
Modified residue59514-hydroxyproline; partial
Modified residue59713',4'-dihydroxyphenylalanine
Modified residue5981(3R,4S)-3,4-dihydroxyproline
Modified residue60113',4'-dihydroxyphenylalanine
Modified residue60514-hydroxyproline; partial
Modified residue60713',4'-dihydroxyphenylalanine
Modified residue6081(3R,4S)-3,4-dihydroxyproline
Modified residue60914-hydroxyproline
Modified residue61113',4'-dihydroxyphenylalanine
Modified residue61514-hydroxyproline; partial
Modified residue61713',4'-dihydroxyphenylalanine
Modified residue6181(3R,4S)-3,4-dihydroxyproline
Modified residue61914-hydroxyproline
Modified residue62113',4'-dihydroxyphenylalanine
Modified residue62514-hydroxyproline; partial
Modified residue62713',4'-dihydroxyphenylalanine
Modified residue6281(3R,4S)-3,4-dihydroxyproline
Modified residue62914-hydroxyproline
Modified residue63113',4'-dihydroxyphenylalanine
Modified residue63514-hydroxyproline; partial
Modified residue63713',4'-dihydroxyphenylalanine
Modified residue6381(3R,4S)-3,4-dihydroxyproline
Modified residue64113',4'-dihydroxyphenylalanine
Modified residue64514-hydroxyproline; partial
Modified residue64713',4'-dihydroxyphenylalanine
Modified residue6481(3R,4S)-3,4-dihydroxyproline
Modified residue64914-hydroxyproline
Modified residue65113',4'-dihydroxyphenylalanine
Modified residue65713',4'-dihydroxyphenylalanine
Modified residue6581(3R,4S)-3,4-dihydroxyproline
Modified residue65914-hydroxyproline
Modified residue66113',4'-dihydroxyphenylalanine
Modified residue66514-hydroxyproline; partial
Modified residue66713',4'-dihydroxyphenylalanine
Modified residue6681(3R,4S)-3,4-dihydroxyproline
Modified residue66914-hydroxyproline
Modified residue67113',4'-dihydroxyphenylalanine
Modified residue67514-hydroxyproline; partial
Modified residue67713',4'-dihydroxyphenylalanine
Modified residue6781(3R,4S)-3,4-dihydroxyproline
Modified residue67914-hydroxyproline
Modified residue68113',4'-dihydroxyphenylalanine
Modified residue70114-hydroxyproline; partial
Modified residue70313',4'-dihydroxyphenylalanine
Modified residue7041(3R,4S)-3,4-dihydroxyproline
Modified residue70514-hydroxyproline
Modified residue70713',4'-dihydroxyphenylalanine
Modified residue71114-hydroxyproline; partial
Modified residue71313',4'-dihydroxyphenylalanine
Modified residue7141(3R,4S)-3,4-dihydroxyproline
Modified residue71514-hydroxyproline
Modified residue71713',4'-dihydroxyphenylalanine
Modified residue72114-hydroxyproline; partial
Modified residue72313',4'-dihydroxyphenylalanine
Modified residue7241(3R,4S)-3,4-dihydroxyproline
Modified residue72514-hydroxyproline
Modified residue72713',4'-dihydroxyphenylalanine
Modified residue73714-hydroxyproline; partial
Modified residue73913',4'-dihydroxyphenylalanine
Modified residue7401(3R,4S)-3,4-dihydroxyproline
Modified residue74313',4'-dihydroxyphenylalanine
Modified residue75314-hydroxyproline; partial
Modified residue75513',4'-dihydroxyphenylalanine
Modified residue7561(3R,4S)-3,4-dihydroxyproline
Modified residue75714-hydroxyproline
Modified residue75913',4'-dihydroxyphenylalanine
Modified residue76314-hydroxyproline; partial
Modified residue76513',4'-dihydroxyphenylalanine
Modified residue7661(3R,4S)-3,4-dihydroxyproline
Modified residue76714-hydroxyproline
Modified residue76913',4'-dihydroxyphenylalanine
Modified residue77314-hydroxyproline; partial
Modified residue77513',4'-dihydroxyphenylalanine
Modified residue7761(3R,4S)-3,4-dihydroxyproline
Modified residue77714-hydroxyproline
Modified residue77913',4'-dihydroxyphenylalanine
Modified residue81314-hydroxyproline; partial
Modified residue81513',4'-dihydroxyphenylalanine
Modified residue8161(3R,4S)-3,4-dihydroxyproline
Modified residue81714-hydroxyproline
Modified residue81913',4'-dihydroxyphenylalanine
Modified residue83314-hydroxyproline; partial
Modified residue83513',4'-dihydroxyphenylalanine
Modified residue8361(3R,4S)-3,4-dihydroxyproline
Modified residue83714-hydroxyproline
Modified residue83913',4'-dihydroxyphenylalanine
Modified residue86513',4'-dihydroxyphenylalanine
Modified residue8661(3R,4S)-3,4-dihydroxyproline
Modified residue86714-hydroxyproline
Modified residue86913',4'-dihydroxyphenylalanine

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q25460 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6EA85312748CAACE

FASTA875100,413
        10         20         30         40         50         60 
TKHEPVYKPV KTSYSAPYKP PTYQPLKKKV DYRPTKSYPP TYGSKTNYLP LAKKLSSYKP 

        70         80         90        100        110        120 
IKTTYNAKTN YPPVYKPKMT YPPTYKPKPS YPPTYKSKPT YKPKITYPPT YKAKPSYPSS 

       130        140        150        160        170        180 
YKPKKTYPPT YKPKLTYPPT YKPKPSYPPT YKPKPSYPPS YKTKKTYPSS YKAKPSYPPT 

       190        200        210        220        230        240 
YKAKPSYPPT YKAKPSYPPT YKAKPTYKAK PTYPSTYKAK PSYPPTYKAK PTYKAKPSYP 

       250        260        270        280        290        300 
PTYKAKPSYP PTYKAKPSYP PTYKAKPTYK AKPTYKAKPT YKAKPSYPPT YKAKPSYPPT 

       310        320        330        340        350        360 
YKAKPSYPPT YKAKPSYPPT YKAKPSYPPT YKAKPSYPPT YKAKPTYKAK PTYPSTYKAK 

       370        380        390        400        410        420 
PSYPPTYKAK PSYPPTYKAK PTYKAKPSYP PTYKAKPSYP PTYKAKPSYP PTYKAKPTYK 

       430        440        450        460        470        480 
AKPTYPSTYK AKPSYPPSYK AKPSYPPTYK AKPTYKAKPT YPSTYKAKPS YPASYKAKPS 

       490        500        510        520        530        540 
YPPTYKSKSS YPSSYKPKKT YPPTYKPKLT YKPTYKPKPS YPPSYKPKTT YPPTYKPKIS 

       550        560        570        580        590        600 
YPPTYKAKPS YPATYKAKPS YPPTYKAKPS YPPTYKAKPS YPPTYKAKPS YKAKPTYPST 

       610        620        630        640        650        660 
YKAKPSYPPT YKAKPSYPPT YKAKPSYPPT YKAKPTYPST YKAKPSYPPT YKPKISYPPT 

       670        680        690        700        710        720 
YKAKPSYPPT YKAKPSYPPT YKAKPTYKAK PTNPSTYKAK PSYPPTYKAK PSYPPTYKAK 

       730        740        750        760        770        780 
PSYPPTYKAK PTYKAKPTYP STYKAKPTYK AKPTYPPTYK AKPSYPPTYK PKPSYPPTYK 

       790        800        810        820        830        840 
SKSIYPSSYK PKKTYPPTYK PKLTYPPTYK PKPSYPPSYK PKITYPSTYK LKPSYPPTYK 

       850        860        870 
SKTSYPPTYN KKISYPSSYK AKTSYPPAYK PTNRY 

« Hide

References

[1]"Structural and functional repetition in a marine mussel adhesive protein."
Filpula D.R., Lee S.M., Link R.P., Strausberg S.L., Strausberg R.L.
Biotechnol. Prog. 6:171-177(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Evidence for a repeating 3,4-dihydroxyphenylalanine- and hydroxyproline-containing decapeptide in the adhesive protein of the mussel, Mytilus edulis L."
Waite J.H.
J. Biol. Chem. 258:2911-2915(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, POST-TRANSLATIONAL MODIFICATIONS.
[3]"Trans-2,3-cis-3,4-dihydroxyproline, a new naturally occurring amino acid, is the sixth residue in the tandemly repeated consensus decapeptides of an adhesive protein from Mytilus edulis."
Taylor S.W., Waite J.H., Ross M.M., Shabanowitz J., Hunt D.F.
J. Am. Chem. Soc. 116:10803-10804(1994)
Cited for: POST-TRANSLATIONAL MODIFICATION, IDENTIFICATION BY MASS SPECTROMETRY, STRUCTURE BY NMR.

Web resources

Protein Spotlight

Sticky business - Issue 2 of September 2001

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54422 Genomic DNA. Translation: CAA38294.1.
PIRS23760.

3D structure databases

ProteinModelPortalQ25460.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002964. Adhesive_plaq.
[Graphical view]
PRINTSPR01216. ADHESIVEI.
ProtoNetSearch...

Entry information

Entry nameFP1_MYTED
AccessionPrimary (citable) accession number: Q25460
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries