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Protein

Tropomyosin

Gene
N/A
Organism
Mytilus edulis (Blue mussel)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin
OrganismiMytilus edulis (Blue mussel)
Taxonomic identifieri6550 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

Pathology & Biotechi

Protein family/group databases

Allergomei2131. Myt e 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056691 – 284TropomyosinAdd BLAST284

Proteomic databases

PRIDEiQ25457.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ25457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q25457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIKKKMVA MKMEKENALD RAEQLEQKLR ETEEAKAKIE DDYNSLQKKS
60 70 80 90 100
IQTENDLDNT QTQLQDVQAK YETTEKQIAE HEQEIQSLTR KISMLEEDIM
110 120 130 140 150
KSEERYTTAA SKLEEASKAA DESERNRKVL ENLNCGNDER IDQLEKQLTE
160 170 180 190 200
AKWIAEEADK KYEEAARKLA ITEVDLERAE ARLEAAEAKV IDLEEQLTVV
210 220 230 240 250
GANIKTLQVQ NDQASQREDS YEETIRDLTN RLKDAENRAT EAERTVSKLR
260 270 280
KEVDRLEDEL LTEKEKYKAI SDELDATFAE LAGY
Length:284
Mass (Da):32,798
Last modified:November 1, 1996 - v1
Checksum:i546800E7A03EFD62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40035 mRNA. Translation: AAA82259.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40035 mRNA. Translation: AAA82259.1.

3D structure databases

ProteinModelPortaliQ25457.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2131. Myt e 1.

Proteomic databases

PRIDEiQ25457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPM_MYTED
AccessioniPrimary (citable) accession number: Q25457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.