Q25457 (TPM_MYTED) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tropomyosin
Organism	Mytilus edulis (Blue mussel)
Taxonomic identifier	6550 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Bivalvia › Pteriomorphia › Mytiloida › Mytiloidea › Mytilidae › Mytilinae › Mytilus

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subunit structure	Homodimer By similarity.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Domain	Coiled coil Repeat
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Tropomyosin		PRO_0000205669
Regions
	Coiled coil	1 – 284	284	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q25457 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 546800E7A03EFD62	FASTA	284	32,798
	10 20 30 40 50 60 MDAIKKKMVA MKMEKENALD RAEQLEQKLR ETEEAKAKIE DDYNSLQKKS IQTENDLDNT 70 80 90 100 110 120 QTQLQDVQAK YETTEKQIAE HEQEIQSLTR KISMLEEDIM KSEERYTTAA SKLEEASKAA 130 140 150 160 170 180 DESERNRKVL ENLNCGNDER IDQLEKQLTE AKWIAEEADK KYEEAARKLA ITEVDLERAE 190 200 210 220 230 240 ARLEAAEAKV IDLEEQLTVV GANIKTLQVQ NDQASQREDS YEETIRDLTN RLKDAENRAT 250 260 270 280 EAERTVSKLR KEVDRLEDEL LTEKEKYKAI SDELDATFAE LAGY

References

[1]	Nyitray L., Yang W., Szent-Gyorgyi A.G. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Anterior byssus retractor muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40035 mRNA. Translation: AAA82259.1.
3D structure databases
ProteinModelPortal	Q25457.
SMR	Q25457. Positions 1-282.
ModBase	Search...
Protein family/group databases
Allergome	2131. Myt e 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPM_MYTED

Accession

Primary (citable) accession number: Q25457

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	October 3, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)