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Q25417

- ALDH2_LEITA

UniProt

Q25417 - ALDH2_LEITA

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Protein

Aldehyde dehydrogenase, mitochondrial

Gene

ALDH2

Organism
Leishmania tarentolae (Sauroleishmania tarentolae)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Could have an RNA-binding activity in addition of its catalytic role.

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661Transition state stabilizerBy similarity
Active sitei265 – 2651Proton acceptorPROSITE-ProRule annotation
Active sitei299 – 2991NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi242 – 2476NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, RNA-binding

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
Alternative name(s):
ALDH class 2
P51
Gene namesi
Name:ALDH2
OrganismiLeishmania tarentolae (Sauroleishmania tarentolae)
Taxonomic identifieri5689 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 99Mitochondrion1 Publication
Chaini10 – 498489Aldehyde dehydrogenase, mitochondrialPRO_0000007171Add
BLAST

Proteomic databases

PRIDEiQ25417.

Structurei

3D structure databases

ProteinModelPortaliQ25417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q25417 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRATLARLE MAPKVTHIQE KLLINGKFVP AVSGKTFEVV NPADEKVIAN
60 70 80 90 100
VAEAEKADVD LAVKAARHAF ESFRMTDCQW RRNLMLRLAD ILEKNSKEMA
110 120 130 140 150
ALESLDNGKP YEVALNVDVA LSVECFRYCA GLADKVNGTV PPRSGNFLGI
160 170 180 190 200
VKRQPIGVCG QIIPWNFPLL MAAFKLSPAL AMGNTVVLKP AEQTPLTAVR
210 220 230 240 250
LGEMVMEAGY PDGVLNILPG FGATAGSEIA RHMDVDKIAF TGSTAVGHQV
260 270 280 290 300
MQMAAETNLK KVSLELGGKS ALIVCEDADL EEAAEVATTR VYFNTGQVCT
310 320 330 340 350
ASSRIYVHES VYDEFVSRLR KNAEARKVGP GNDTGNNMGP LVSKKQHERV
360 370 380 390 400
LGYIEDGVKA GATVVTGGKK IGDKGYFVQP TIFSDVKEDM RICKEEIFGP
410 420 430 440 450
VTCVMKYKDM DEVVKRANDS IYGLAAGICT RSMDTALRYS TYLNAGTVWV
460 470 480 490
NTWNNFCPSM PFGGFKQSGI GRELGKEVVD MYTEPKAIHF ASRSIVKP
Length:498
Mass (Da):54,252
Last modified:November 1, 1996 - v1
Checksum:i618D55F6ED5547EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z31698 Genomic DNA. Translation: CAA83503.1.
PIRiS43184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z31698 Genomic DNA. Translation: CAA83503.1 .
PIRi S43184.

3D structure databases

ProteinModelPortali Q25417.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q25417.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view ]
PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of two nuclear-encoded protein components of mitochondrial ribonucleoprotein complexes from Leishmania tarentolae."
    Bringaud F., Peris M., Zen K.H., Simpson L.
    Mol. Biochem. Parasitol. 71:65-79(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 10-31.
    Strain: UC.

Entry informationi

Entry nameiALDH2_LEITA
AccessioniPrimary (citable) accession number: Q25417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3