Reviewed, UniProtKB/Swiss-Prot Q25417 (ALDH2_LEITA)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase, mitochondrial
    EC=1.2.1.3
Alternative name(s):
    ALDH class 2
    P51

Gene names

Name:

ALDH2

Organism

Leishmania tarentolae (Sauroleishmania tarentolae)

Taxonomic identifier

5689 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Leishmania › lizard Leishmania

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Could have a RNA-binding activity in addition of its catalytic role.
Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NAD RNA-binding
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 9	9	Mitochondrion Ref.1
	Chain	10 – 498	489	Aldehyde dehydrogenase, mitochondrial		PRO_0000007171
Regions
	Nucleotide binding	242 – 247	6	NAD By similarity
Sites
	Active site	265	1	Proton acceptor By similarity
	Active site	299	1	Nucleophile By similarity
	Site	166	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q25417-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 618D55F6ED5547EC	FASTA	498	54,252
	10 20 30 40 50 60 MLRATLARLE MAPKVTHIQE KLLINGKFVP AVSGKTFEVV NPADEKVIAN VAEAEKADVD 70 80 90 100 110 120 LAVKAARHAF ESFRMTDCQW RRNLMLRLAD ILEKNSKEMA ALESLDNGKP YEVALNVDVA 130 140 150 160 170 180 LSVECFRYCA GLADKVNGTV PPRSGNFLGI VKRQPIGVCG QIIPWNFPLL MAAFKLSPAL 190 200 210 220 230 240 AMGNTVVLKP AEQTPLTAVR LGEMVMEAGY PDGVLNILPG FGATAGSEIA RHMDVDKIAF 250 260 270 280 290 300 TGSTAVGHQV MQMAAETNLK KVSLELGGKS ALIVCEDADL EEAAEVATTR VYFNTGQVCT 310 320 330 340 350 360 ASSRIYVHES VYDEFVSRLR KNAEARKVGP GNDTGNNMGP LVSKKQHERV LGYIEDGVKA 370 380 390 400 410 420 GATVVTGGKK IGDKGYFVQP TIFSDVKEDM RICKEEIFGP VTCVMKYKDM DEVVKRANDS 430 440 450 460 470 480 IYGLAAGICT RSMDTALRYS TYLNAGTVWV NTWNNFCPSM PFGGFKQSGI GRELGKEVVD 490 MYTEPKAIHF ASRSIVKP

References

[1]

"Characterization of two nuclear-encoded protein components of mitochondrial ribonucleoprotein complexes from Leishmania tarentolae." Bringaud F., Peris M., Zen K.H., Simpson L. Mol. Biochem. Parasitol. 71:65-79(1995) [PubMed: 7630384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 10-31. Strain: UC.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z31698 Genomic DNA. Translation: CAA83503.1.
PIR	S43184.
3D structure databases
HSSP	HSSP built from PDB template 1O01 based on UniProtKB P05091.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.3. 1138.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH2_LEITA

Accession

Primary (citable) accession number: Q25417

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)