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Q25417

- ALDH2_LEITA

UniProt

Q25417 - ALDH2_LEITA

Protein

Aldehyde dehydrogenase, mitochondrial

Gene

ALDH2

Organism
Leishmania tarentolae (Sauroleishmania tarentolae)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Could have an RNA-binding activity in addition of its catalytic role.

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei166 – 1661Transition state stabilizerBy similarity
    Active sitei265 – 2651Proton acceptorPROSITE-ProRule annotation
    Active sitei299 – 2991NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi242 – 2476NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, RNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
    Alternative name(s):
    ALDH class 2
    P51
    Gene namesi
    Name:ALDH2
    OrganismiLeishmania tarentolae (Sauroleishmania tarentolae)
    Taxonomic identifieri5689 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmanializard Leishmania

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 99Mitochondrion1 Publication
    Chaini10 – 498489Aldehyde dehydrogenase, mitochondrialPRO_0000007171Add
    BLAST

    Proteomic databases

    PRIDEiQ25417.

    Structurei

    3D structure databases

    ProteinModelPortaliQ25417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view]
    PANTHERiPTHR11699:SF46. PTHR11699:SF46. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q25417-1 [UniParc]FASTAAdd to Basket

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    MLRATLARLE MAPKVTHIQE KLLINGKFVP AVSGKTFEVV NPADEKVIAN    50
    VAEAEKADVD LAVKAARHAF ESFRMTDCQW RRNLMLRLAD ILEKNSKEMA 100
    ALESLDNGKP YEVALNVDVA LSVECFRYCA GLADKVNGTV PPRSGNFLGI 150
    VKRQPIGVCG QIIPWNFPLL MAAFKLSPAL AMGNTVVLKP AEQTPLTAVR 200
    LGEMVMEAGY PDGVLNILPG FGATAGSEIA RHMDVDKIAF TGSTAVGHQV 250
    MQMAAETNLK KVSLELGGKS ALIVCEDADL EEAAEVATTR VYFNTGQVCT 300
    ASSRIYVHES VYDEFVSRLR KNAEARKVGP GNDTGNNMGP LVSKKQHERV 350
    LGYIEDGVKA GATVVTGGKK IGDKGYFVQP TIFSDVKEDM RICKEEIFGP 400
    VTCVMKYKDM DEVVKRANDS IYGLAAGICT RSMDTALRYS TYLNAGTVWV 450
    NTWNNFCPSM PFGGFKQSGI GRELGKEVVD MYTEPKAIHF ASRSIVKP 498
    Length:498
    Mass (Da):54,252
    Last modified:November 1, 1996 - v1
    Checksum:i618D55F6ED5547EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z31698 Genomic DNA. Translation: CAA83503.1.
    PIRiS43184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z31698 Genomic DNA. Translation: CAA83503.1 .
    PIRi S43184.

    3D structure databases

    ProteinModelPortali Q25417.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q25417.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR015657. Aminobutyraldehyde_DH.
    [Graphical view ]
    PANTHERi PTHR11699:SF46. PTHR11699:SF46. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two nuclear-encoded protein components of mitochondrial ribonucleoprotein complexes from Leishmania tarentolae."
      Bringaud F., Peris M., Zen K.H., Simpson L.
      Mol. Biochem. Parasitol. 71:65-79(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 10-31.
      Strain: UC.

    Entry informationi

    Entry nameiALDH2_LEITA
    AccessioniPrimary (citable) accession number: Q25417
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3