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Protein

Protein kinase C

Gene

PKC1

Organism
Lytechinus pictus (Painted sea urchin)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.By similarity
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei354ATPPROSITE-ProRule annotation1
Active sitei449Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri27 – 77Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri92 – 142Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi331 – 339ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C (EC:2.7.11.13)
Gene namesi
Name:PKC1
OrganismiLytechinus pictus (Painted sea urchin)
Taxonomic identifieri7653 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaTemnopleuroidaToxopneustidaeLytechinus

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557291 – 658Protein kinase CAdd BLAST658

Proteomic databases

PRIDEiQ25378

Structurei

3D structure databases

ProteinModelPortaliQ25378
SMRiQ25378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 251C2PROSITE-ProRule annotationAdd BLAST88
Domaini325 – 583Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini584 – 654AGC-kinase C-terminalAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri27 – 77Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri92 – 142Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR014375 Protein_kinase_C_a/b/g
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00168 C2, 1 hit
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000550 PKC_alpha, 1 hit
PRINTSiPR00360 C2DOMAIN
PR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00239 C2, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50004 C2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q25378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSTLEMKG FARRGALRQK NVHEIKNHKF IPRFFKQPTF CSHCKDFIWG
60 70 80 90 100
FGKQGFQCKV CSFVVHKRCH EFVTFQCPGL DPGVDSDDPR NKHKFKVHSY
110 120 130 140 150
NSPTFCDHCG SLLYGLYHQG MKCGACDMNV HKRCQKSVPN LCGADHTERR
160 170 180 190 200
GRIKVKAEVI GNKLQVTVAE AKNLIPMDPN GLSDPFVKLK LIPDQKRETK
210 220 230 240 250
KKTRTIKGSL NPTWGESFDF NLEDTDRNRR LLVEVWDWDR ATRNDFMGAL
260 270 280 290 300
SFGISELMKA GVDAWYKLLG QEEGEYYNVP AIAETESIDE LTSNIKKLPM
310 320 330 340 350
PTQEHVKPQN SNSMSGMGVV RASDFNFLSV LGKGSFGKVM LAEKKGTDEL
360 370 380 390 400
YAIKILKKDV IIQDDDVECT MTEKRVLGLP SKPAFLTALH SCFQTMDRLF
410 420 430 440 450
FVMEFVNGGD LMFQIQKVGK FREPHAVFYA AEIAVGLFYL HSQGVIYRDL
460 470 480 490 500
KLDNVLVDAE GHIKIADFGM CKEHMNEGDT TRTFCGTPDY IAPEIVAYQP
510 520 530 540 550
YGKAVDWWAF GVLLYEMLAG QPPFDGEDED ELFQSIMEHV PSYPKSMSRE
560 570 580 590 600
SVTMCKGFLT KHPGKRLGSG PTGEQDIREH QFFRRIDWEK LANREIQPPF
610 620 630 640 650
VPSVRNPRAA ENFDPYFTKI PCALTPTDKL IIMNIQDEFQ GFTFVNEVFD

GYVRSLPS
Length:658
Mass (Da):74,871
Last modified:November 1, 1996 - v1
Checksum:i74B5A27A49C835A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02967 mRNA Translation: AAA03447.1

Similar proteinsi

Entry informationi

Entry nameiKPC1_LYTPI
AccessioniPrimary (citable) accession number: Q25378
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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