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Protein
Submitted name:

Cathepsin B-like enzyme

Gene

lmcpc

Organism
Leishmania mexicana
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiC01.098.

Names & Taxonomyi

Protein namesi
Submitted name:
Cathepsin B-like enzymeImported
Gene namesi
Name:lmcpcImported
OrganismiLeishmania mexicanaImported
Taxonomic identifieri5665 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525UniRule annotationAdd
BLAST
Chaini26 – 340315UniRule annotationPRO_5005400165Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi929439.XP_003872479.1.

Structurei

3D structure databases

ProteinModelPortaliQ25319.
SMRiQ25319. Positions 98-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 336239Pept_C1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q25319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRTKSALC LVAVFVVLLA TTVSALYAKP SDIPLLGKSF VAETNSKAKG
60 70 80 90 100
QWTASADNGH LVTGKSLEEV RKLMGVTSMS TEAVPPRNFS VEEMQQDLPE
110 120 130 140 150
SFDASEKWPM CVTIGEIRDQ SNCGSCWAIA AVEAMSDRYC TMSGIPDRRI
160 170 180 190 200
STTNLLSCCF ICGFGCYGGI PAMAWLWWVW VGVTTELCQP YPFGPCSHHG
210 220 230 240 250
NSSKYPPCPN TIYNTPKCNT TCDNVEMELV KYKGVSSYSI KGERELDHEL
260 270 280 290 300
MNNGPLEVAM QVYADFVAYK SGVYKHVSGD HLGGHAVKLV GWGVKDGIPY
310 320 330 340
WKIANSWNTD WGDKGYFLIQ RGNDECGIES SGVAGKPGEE
Length:340
Mass (Da):37,200
Last modified:November 1, 1996 - v1
Checksum:i15680C7862E2EC36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48599 Genomic DNA. Translation: CAA88490.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48599 Genomic DNA. Translation: CAA88490.1.

3D structure databases

ProteinModelPortaliQ25319.
SMRiQ25319. Positions 98-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi929439.XP_003872479.1.

Protein family/group databases

MEROPSiC01.098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cathepsin B-like cysteine proteases of Leishmania mexicana."
    Bart G., Coombs G.H.
    Mol. Biochem. Parasitol. 62:271-279(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MNY/BZ/62/M379Imported.
  2. Mottram J.C.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MNY/BZ/62/M379Imported.

Entry informationi

Entry nameiQ25319_LEIME
AccessioniPrimary (citable) accession number: Q25319
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.