ID   HEMH_CHLFF              Reviewed;         318 AA.
AC   Q252Z7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Ferrochelatase;
DE            EC=4.99.1.1;
DE   AltName: Full=Protoheme ferro-lyase;
DE   AltName: Full=Heme synthetase;
GN   Name=hemH; OrderedLocusNames=CF0869;
OS   Chlamydophila felis (strain Fe/C-56).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydophila.
OX   NCBI_TaxID=264202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16766509; DOI=10.1093/dnares/dsi027;
RA   Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H.,
RA   Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H.,
RA   Fukushi H., Hattori M., Kuhara S., Shirai M.;
RT   "Genome sequence of the cat pathogen, Chlamydophila felis.";
RL   DNA Res. 13:15-23(2006).
CC   -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX.
CC   -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
CC   -!- PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme
CC       from protoporphyrin-IX: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ferrochelatase family.
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DR   EMBL; AP006861; BAE81641.1; -; Genomic_DNA.
DR   RefSeq; YP_515786.1; -.
DR   GeneID; 3958490; -.
DR   GenomeReviews; AP006861_GR; CF0869.
DR   KEGG; cfe:CF0869; -.
DR   HOGENOM; Q252Z7; -.
DR   OMA; Q252Z7; VKWLEPS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00323; -; 1.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR019772; Ferrochelatase_AS.
DR   PANTHER; PTHR11108; Ferrochelatase; 1.
DR   Pfam; PF00762; Ferrochelatase; 1.
DR   ProDom; PD002792; Ferrochelatase; 1.
DR   TIGRFAMs; TIGR00109; hemH; 1.
DR   PROSITE; PS00534; FERROCHELATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Heme biosynthesis; Iron; Lyase;
KW   Metal-binding; Porphyrin biosynthesis.
FT   CHAIN         1    318       Ferrochelatase.
FT                                /FTId=PRO_1000019291.
FT   METAL       186    186       Iron (By similarity).
FT   METAL       264    264       Iron (By similarity).
SQ   SEQUENCE   318 AA;  36426 MW;  D2B10F44E574954E CRC64;
     MVSVYLLANF GGPRHASDIE VFLTSLLTDR DVTGKFLPPF IHKRLFSFIA KKRVAKVLPQ
     YNCIGGFSPI YRDTEDLADT LSLYLDAPVI TFHRYLPDTH QLTVQRLKAF GDCPVIGVPL
     FPHFTYSVTG SIVRFIHAHL PLLNISWISH FGNHPQFIFC MIDHILKFLQ SHDISIHDCC
     LLFSAHGLPM RYINKGDPYN KHCEKSFKTI SERLPNIETH LCYQSKFGPG RWLTPSTKDV
     CETLKTDKTY VLIVPFGFTS DHIETLYEIE KEYIPILKAR EYRALRVPAI YQSPEWAASL
     ATIIQSTPRA EKESLIKP
//