Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q252Z7 (HEMH_CHLFF) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:CF0869
OrganismChlamydophila felis (strain Fe/C-56) [Complete proteome] [HAMAP]
Taxonomic identifier264202 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Ferrochelatase HAMAP MF_00323
PRO_1000019291

Sites

Metal binding1861Iron By similarity
Metal binding2641Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q252Z7 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: D2B10F44E574954E

FASTA31836,426
        10         20         30         40         50         60 
MVSVYLLANF GGPRHASDIE VFLTSLLTDR DVTGKFLPPF IHKRLFSFIA KKRVAKVLPQ 

        70         80         90        100        110        120 
YNCIGGFSPI YRDTEDLADT LSLYLDAPVI TFHRYLPDTH QLTVQRLKAF GDCPVIGVPL 

       130        140        150        160        170        180 
FPHFTYSVTG SIVRFIHAHL PLLNISWISH FGNHPQFIFC MIDHILKFLQ SHDISIHDCC 

       190        200        210        220        230        240 
LLFSAHGLPM RYINKGDPYN KHCEKSFKTI SERLPNIETH LCYQSKFGPG RWLTPSTKDV 

       250        260        270        280        290        300 
CETLKTDKTY VLIVPFGFTS DHIETLYEIE KEYIPILKAR EYRALRVPAI YQSPEWAASL 

       310 
ATIIQSTPRA EKESLIKP

« Hide

References

[1]"Genome sequence of the cat pathogen, Chlamydophila felis."
Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H., Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H., Hattori M., Kuhara S., Shirai M.
DNA Res. 13:15-23(2006) [PubMed: 16766509] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Fe/C-56.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006861 Genomic DNA. Translation: BAE81641.1.
RefSeqYP_515786.1. NC_007899.1.

3D structure databases

ProteinModelPortalQ252Z7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ252Z7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3958490.
GenomeReviewsGene locus CF0869 in contig AP006861_GR.
KEGGcfe:CF0869.
PATRIC20205431. VBIChlFel51660_0914.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBQ252Z7.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycCFEL264202:CF0869-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_CHLFF
AccessionPrimary (citable) accession number: Q252Z7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents