Reviewed, UniProtKB/Swiss-Prot Q252Z7 (HEMH_CHLFF)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	CF0869

Organism

Chlamydophila felis (strain Fe/C-56) [Complete proteome] [HAMAP]

Taxonomic identifier

264202 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Ferrochelatase HAMAP MF_00323		PRO_1000019291
Sites
	Metal binding	186	1	Iron By similarity
	Metal binding	264	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q252Z7-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: D2B10F44E574954E	FASTA	318	36,426
	10 20 30 40 50 60 MVSVYLLANF GGPRHASDIE VFLTSLLTDR DVTGKFLPPF IHKRLFSFIA KKRVAKVLPQ 70 80 90 100 110 120 YNCIGGFSPI YRDTEDLADT LSLYLDAPVI TFHRYLPDTH QLTVQRLKAF GDCPVIGVPL 130 140 150 160 170 180 FPHFTYSVTG SIVRFIHAHL PLLNISWISH FGNHPQFIFC MIDHILKFLQ SHDISIHDCC 190 200 210 220 230 240 LLFSAHGLPM RYINKGDPYN KHCEKSFKTI SERLPNIETH LCYQSKFGPG RWLTPSTKDV 250 260 270 280 290 300 CETLKTDKTY VLIVPFGFTS DHIETLYEIE KEYIPILKAR EYRALRVPAI YQSPEWAASL 310 ATIIQSTPRA EKESLIKP

References

[1]

"Genome sequence of the cat pathogen, Chlamydophila felis." Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H., Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H., Hattori M., Kuhara S., Shirai M. DNA Res. 13:15-23(2006) [PubMed: 16766509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006861 Genomic DNA. Translation: BAE81641.1.
RefSeq	YP_515786.1.
3D structure databases
SMR	Q252Z7. Positions 5-308.
ModBase	Search...
Protein-protein interaction databases
STRING	Q252Z7.
Genome annotation databases
GeneID	3958490.
GenomeReviews	Gene locus CF0869 in contig AP006861_GR.
KEGG	cfe:CF0869.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0276.
HOGENOM	HBG697135.
OMA	PEMPNAS.
Enzyme and pathway databases
BioCyc	CFEL264202:CF0869-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_CHLFF

Accession

Primary (citable) accession number: Q252Z7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 18, 2006
Last modified:	February 9, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)