Q252U8 (LPXC_CHLFF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
EC=3.5.1.-

Alternative name(s):
UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	CF0918

Organism

Chlamydophila felis (strain Fe/C-56) [Complete proteome] [HAMAP]

Taxonomic identifier

264202 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00388
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. HAMAP MF_00388
Sequence similarities	Belongs to the LpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388		PRO_0000253658

Sequences

	Sequence		Length	Mass (Da)
	Q252U8 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 9CBD87A4F2EAEF6C	FASTA	280	30,887
	10 20 30 40 50 60 MLERAQRTLK RKVHYSGVGI HFGKSATLTL EPAEENTGIV FYRSDLLGDR IPALLPHVCN 70 80 90 100 110 120 TGRSTTLSSG DSVIATVEHL MAALRSSNID NVIVRCGEEE IPIGDGSSHV FMQLIDEAGI 130 140 150 160 170 180 CTQNDTVPIA KLARPVYYQT QDTFLAAFPC DELKISYTLH YPQSPTIGTQ YRSFVITEES 190 200 210 220 230 240 FRKEIAPCRT FALYNELCFL MDRGLIRGGC LENAVVFKDD GIISLGQLRF PDEPVRHKIL 250 260 270 280 DLIGDLSLVG RPFVAHIVAV GSGHSSNIAL GRKILEELQP

References

[1]

"Genome sequence of the cat pathogen, Chlamydophila felis." Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H., Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H., Hattori M., Kuhara S., Shirai M. DNA Res. 13:15-23(2006) [PubMed: 16766509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fe/C-56.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006861 Genomic DNA. Translation: BAE81690.1.
RefSeq	YP_515835.1. NC_007899.1.
3D structure databases
ProteinModelPortal	Q252U8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q252U8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3958443.
GenomeReviews	Gene locus CF0918 in contig AP006861_GR.
KEGG	cfe:CF0918.
PATRIC	20205535. VBIChlFel51660_0964.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0774.
HOGENOM	HBG482342.
OMA	KAYKSGH.
PhylomeDB	Q252U8.
ProtClustDB	PRK13186.
Enzyme and pathway databases
BioCyc	CFEL264202:CF0918-MONOMER.
Family and domain databases
HAMAP	MF_00388. LpxC. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
KO	K02535.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
TIGRFAMs	TIGR00325. LpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXC_CHLFF

Accession

Primary (citable) accession number: Q252U8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program