Reviewed, UniProtKB/Swiss-Prot Q252N1 (KDSA_CHLFF)

Names and origin

Protein names

Recommended name:
    2-dehydro-3-deoxyphosphooctonate aldolase
    EC=2.5.1.55
Alternative name(s):
    Phospho-2-dehydro-3-deoxyoctonate aldolase
    3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase
    KDO-8-phosphate synthetase
      Short name=KDO 8-P synthase
      Short name=KDOPS

Gene names

Name:	kdsA
Ordered Locus Names:	CF0985

Organism

Chlamydophila felis (strain Fe/C-56) [Complete proteome] [HAMAP]

Taxonomic identifier

264202 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the kdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000304444

Sequences

	Sequence		Length	Mass (Da)
	Q252N1-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: BF4DFB1BB0F23B49	FASTA	269	29,235
	10 20 30 40 50 60 MFSDKMILIA GPCVIEGEEI TLEIASKIHE LVSPYADRIH WIFKSSYDKA NRSSINSYRG 70 80 90 100 110 120 PGLSEGLRIL SKVKETLGVE ILTDVHSPEE ARAAAEVCDI LQIPAFLCRQ TDLLVAAAET 130 140 150 160 170 180 NAIINIKKGQ FLSPWDMQGP VDKVLSTGNN KIILTERGCS FGYNNLVSDM RSIPVLSSMG 190 200 210 220 230 240 FPVVFDGTHS VQLPGGLKTQ SGGQTEFIPT LTRAALAAGA HGLFIETHSH PAIAKSDAAS 250 260 MLPLKTFEAL LPLWDQLYTC VRSFEMASV

References

[1]

"Genome sequence of the cat pathogen, Chlamydophila felis." Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H., Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H., Hattori M., Kuhara S., Shirai M. DNA Res. 13:15-23(2006) [PubMed: 16766509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006861 Genomic DNA. Translation: BAE81757.1.
RefSeq	YP_515902.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q252N1.
Genome annotation databases
GeneID	3958922.
GenomeReviews	Gene locus CF0985 in contig AP006861_GR.
KEGG	cfe:CF0985.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q252N1.
OMA	VYKTSFD.
Family and domain databases
HAMAP	MF_00056. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_CHLFF

Accession

Primary (citable) accession number: Q252N1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	April 18, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)