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Q251P8

- FTHS1_DESHY

UniProt

Q251P8 - FTHS1_DESHY

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Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDHAF138119:GHT5-209-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 1UniRule annotation
Short name:
FHS 1UniRule annotation
Short name:
FTHFS 1UniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Ordered Locus Names:DSY0205
OrganismiDesulfitobacterium hafniense (strain Y51)
Taxonomic identifieri138119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000001946: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligase 1PRO_0000293034Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi138119.DSY0205.

Structurei

3D structure databases

ProteinModelPortaliQ251P8.
SMRiQ251P8. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q251P8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIAQE ATMKPITEIA QGLDLLEDEI ELYGKYKAKV NFSAWERLKD
60 70 80 90 100
KPDAKLILVT AINPTPAGEG KTTTTVGLGQ AMSKIGKNAM IALREPSLGP
110 120 130 140 150
CFGVKGGAAG GGYAQVVPME DINLHFTGDF HAITSTHNLL AALLDNHIQQ
160 170 180 190 200
GNLLNIDPRQ IVFRRVMDMN DRALRKIVIG LGGRTEGIPR ENGFDITVAS
210 220 230 240 250
EIMAILCLAK DLMDLKERFG RIVVAYTYDG KAITAHDLEA EGAMALLMKD
260 270 280 290 300
AIKPNLVQTL ENTPVFIHGG PFANIAHGCN SVVATRMAMK LADYVITEAG
310 320 330 340 350
FGADLGAEKF YDLKCRFAEL KPAATVIVAT VRALKMNGGV AKEDLGPENL
360 370 380 390 400
EALAKGIVNL EKHIENIGKF GVPAVVAINR FPTDTDAELE FVAERCRQLG
410 420 430 440 450
AEFALSEVFT KGGEGGIELA KAVLNIVDNK ESNFHVLYEL DLPIAKKIET
460 470 480 490 500
ICKEVYGADG VNFTKEALTS MKKYEELGYG QLPICMAKTQ YSLTDDQNVL
510 520 530 540 550
GRPSGFTITV RELRLSAGAG FLVAITGAIM TMPGLPKRPA ALRMDIDAAG

RITGLF
Length:556
Mass (Da):60,058
Last modified:April 18, 2006 - v1
Checksum:i3ED979494B7BE038
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008230 Genomic DNA. Translation: BAE81994.1.
RefSeqiYP_516438.1. NC_007907.1.

Genome annotation databases

EnsemblBacteriaiBAE81994; BAE81994; DSY0205.
GeneIDi3953868.
KEGGidsy:DSY0205.
PATRICi21668491. VBIDesHaf65307_0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008230 Genomic DNA. Translation: BAE81994.1 .
RefSeqi YP_516438.1. NC_007907.1.

3D structure databases

ProteinModelPortali Q251P8.
SMRi Q251P8. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 138119.DSY0205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE81994 ; BAE81994 ; DSY0205 .
GeneIDi 3953868.
KEGGi dsy:DSY0205.
PATRICi 21668491. VBIDesHaf65307_0236.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DHAF138119:GHT5-209-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
    Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
    J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y51.

Entry informationi

Entry nameiFTHS1_DESHY
AccessioniPrimary (citable) accession number: Q251P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 18, 2006
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3