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Q251P8 (FTHS1_DESHY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase 1

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase 1
Short name=FHS 1
Short name=FTHFS 1
Gene names
Name:fhs1
Ordered Locus Names:DSY0205
OrganismDesulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]
Taxonomic identifier138119 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase 1 HAMAP-Rule MF_01543
PRO_0000293034

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q251P8 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: 3ED979494B7BE038

FASTA55660,058
        10         20         30         40         50         60 
MKTDIEIAQE ATMKPITEIA QGLDLLEDEI ELYGKYKAKV NFSAWERLKD KPDAKLILVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTTTVGLGQ AMSKIGKNAM IALREPSLGP CFGVKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
DINLHFTGDF HAITSTHNLL AALLDNHIQQ GNLLNIDPRQ IVFRRVMDMN DRALRKIVIG 

       190        200        210        220        230        240 
LGGRTEGIPR ENGFDITVAS EIMAILCLAK DLMDLKERFG RIVVAYTYDG KAITAHDLEA 

       250        260        270        280        290        300 
EGAMALLMKD AIKPNLVQTL ENTPVFIHGG PFANIAHGCN SVVATRMAMK LADYVITEAG 

       310        320        330        340        350        360 
FGADLGAEKF YDLKCRFAEL KPAATVIVAT VRALKMNGGV AKEDLGPENL EALAKGIVNL 

       370        380        390        400        410        420 
EKHIENIGKF GVPAVVAINR FPTDTDAELE FVAERCRQLG AEFALSEVFT KGGEGGIELA 

       430        440        450        460        470        480 
KAVLNIVDNK ESNFHVLYEL DLPIAKKIET ICKEVYGADG VNFTKEALTS MKKYEELGYG 

       490        500        510        520        530        540 
QLPICMAKTQ YSLTDDQNVL GRPSGFTITV RELRLSAGAG FLVAITGAIM TMPGLPKRPA 

       550 
ALRMDIDAAG RITGLF 

« Hide

References

[1]"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y51.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008230 Genomic DNA. Translation: BAE81994.1.
RefSeqYP_516438.1. NC_007907.1.

3D structure databases

ProteinModelPortalQ251P8.
SMRQ251P8. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING138119.DSY0205.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE81994; BAE81994; DSY0205.
GeneID3953868.
KEGGdsy:DSY0205.
PATRIC21668491. VBIDesHaf65307_0236.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAEEPAHYT.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycDHAF138119:GHT5-209-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS1_DESHY
AccessionPrimary (citable) accession number: Q251P8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 18, 2006
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways