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Q251P8

- FTHS1_DESHY

UniProt

Q251P8 - FTHS1_DESHY

Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDHAF138119:GHT5-209-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 1UniRule annotation
    Short name:
    FHS 1UniRule annotation
    Short name:
    FTHFS 1UniRule annotation
    Gene namesi
    Name:fhs1UniRule annotation
    Ordered Locus Names:DSY0205
    OrganismiDesulfitobacterium hafniense (strain Y51)
    Taxonomic identifieri138119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
    ProteomesiUP000001946: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligase 1PRO_0000293034Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi138119.DSY0205.

    Structurei

    3D structure databases

    ProteinModelPortaliQ251P8.
    SMRiQ251P8. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIPRESGF.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q251P8-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQE ATMKPITEIA QGLDLLEDEI ELYGKYKAKV NFSAWERLKD    50
    KPDAKLILVT AINPTPAGEG KTTTTVGLGQ AMSKIGKNAM IALREPSLGP 100
    CFGVKGGAAG GGYAQVVPME DINLHFTGDF HAITSTHNLL AALLDNHIQQ 150
    GNLLNIDPRQ IVFRRVMDMN DRALRKIVIG LGGRTEGIPR ENGFDITVAS 200
    EIMAILCLAK DLMDLKERFG RIVVAYTYDG KAITAHDLEA EGAMALLMKD 250
    AIKPNLVQTL ENTPVFIHGG PFANIAHGCN SVVATRMAMK LADYVITEAG 300
    FGADLGAEKF YDLKCRFAEL KPAATVIVAT VRALKMNGGV AKEDLGPENL 350
    EALAKGIVNL EKHIENIGKF GVPAVVAINR FPTDTDAELE FVAERCRQLG 400
    AEFALSEVFT KGGEGGIELA KAVLNIVDNK ESNFHVLYEL DLPIAKKIET 450
    ICKEVYGADG VNFTKEALTS MKKYEELGYG QLPICMAKTQ YSLTDDQNVL 500
    GRPSGFTITV RELRLSAGAG FLVAITGAIM TMPGLPKRPA ALRMDIDAAG 550
    RITGLF 556
    Length:556
    Mass (Da):60,058
    Last modified:April 18, 2006 - v1
    Checksum:i3ED979494B7BE038
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE81994.1.
    RefSeqiYP_516438.1. NC_007907.1.

    Genome annotation databases

    EnsemblBacteriaiBAE81994; BAE81994; DSY0205.
    GeneIDi3953868.
    KEGGidsy:DSY0205.
    PATRICi21668491. VBIDesHaf65307_0236.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE81994.1 .
    RefSeqi YP_516438.1. NC_007907.1.

    3D structure databases

    ProteinModelPortali Q251P8.
    SMRi Q251P8. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 138119.DSY0205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE81994 ; BAE81994 ; DSY0205 .
    GeneIDi 3953868.
    KEGGi dsy:DSY0205.
    PATRICi 21668491. VBIDesHaf65307_0236.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IPRESGF.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DHAF138119:GHT5-209-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
      Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
      J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y51.

    Entry informationi

    Entry nameiFTHS1_DESHY
    AccessioniPrimary (citable) accession number: Q251P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3