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Q25197

- HTK7_HYDVU

UniProt

Q25197 - HTK7_HYDVU

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Protein
Putative insulin-like peptide receptor
Gene
HTK7
Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactori

Manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1077 – 10771ATP By similarity
Active sitei1175 – 11751Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1050 – 10589ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. protein autophosphorylation Source: InterPro
  2. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative insulin-like peptide receptor (EC:2.7.10.1)
Gene namesi
Name:HTK7
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 980956Extracellular Reviewed prediction
Add
BLAST
Transmembranei981 – 100121Helical; Reviewed prediction
Add
BLAST
Topological domaini1002 – 1477476Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 14771453Putative insulin-like peptide receptor
PRO_0000016714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi255 – 2551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi549 – 5491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi644 – 6441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi732 – 7321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi791 – 7911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi874 – 8741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi895 – 8951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi957 – 9571N-linked (GlcNAc...) Reviewed prediction
Modified residuei1201 – 12011Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Expressed in dividing epithelial cells.

Structurei

3D structure databases

ProteinModelPortaliQ25197.
SMRiQ25197. Positions 1022-1329.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini652 – 75099Fibronectin type-III 1
Add
BLAST
Domaini780 – 86990Fibronectin type-III 2
Add
BLAST
Domaini880 – 97192Fibronectin type-III 3
Add
BLAST
Domaini1044 – 1315272Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.80.20.20. 3 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR003961. Fibronectin_type3.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000620. Insulin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q25197-1 [UniParc]FASTAAdd to Basket

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MMRNVQSFYF LFLLIVLNFH VVLSAVCIGQ RATTTIWLNQ NGDCQDVGFC     50
QYLQNCTCWH GNLVVKSTKY YDEENFKPYF PKLREITGYL LISLCTLKFF 100
HLFPGLTVIR GGDLILNYAL VIYYNEIKEV YFPSLTAILN GGVHIGRNHR 150
LCYVNTIRWK SIIKDIHQTG QYGIYLESNK LNCDLGCLKG HCHPAPGHDG 200
DPKAQYCWGP GPKKQQNKAQ CQRFCNTQCG PEGCLDGSDH ICCHHECLGG 250
CSAINSTNTC HACRKYRIKS TGQCVSKCPR KQYLVDKFLC QESCPYWSIN 300
STEYHHYLWQ GECVTKCPVN YISNNQTKKC EKCKSGMKCN TVCKYQDVMA 350
DGTLYNGALI RVPSDISKKG LVGCSVFEGS LTFQLQEGTG KAEDSLNELK 400
SLKVLKGHLK IQKSSLKSLN FLSSLEVIET PQNALLHNKY VMAVYENSQL 450
SELWPGNESI IVSDGGIFFQ YNPRLCPLHI RNLQDRIHYK NGSKVTGEVS 500
LQNNGHKVLC DTQMLVMHVE EFIPPDLNME TDMTAIECNS FKCVKVTWNF 550
TMTSAYNNIL FYAIYFKELQ SNQEAVVQLD NECQNNDDWN VITVDIPKIE 600
SLEQSLFLQS KIISKLTPYT RYAFYIKEIV SKGEERSSHI HYINISQDLP 650
SEPLGVEASF LSENKILLKW RAPSKPNGII TAFKIYYNKP DYSFWEEQKV 700
LDWCSRDASR DKNAKDVAGY PVNKENYNQY CNISCVCDEE KENSKAIKAD 750
REAHNFNVEF QTELMRVLFT KNKFSYRNKN KSPPKIDFSK NISLILSNKI 800
LTSTSTTVTQ AKIEIIEEPK VTVNGNIFSY VISGLDYFED YELKVCGCTV 850
VGCRRPSSTI NLDCGIVQAR TGVNLTADNL DSKMVRVQVQ LDSYNISWIA 900
PHKPNAVILK YEISIRYALD KDALVICRPG YLPTYIIRKS RFGNYVAKIR 950
AISPAGNGSW TEEIHFKVAE LSVTKNNNQL IIGIISAVSA VIVALLVFIL 1000
LYMFLHRKLE KDVQGVLYAS VNPEYMNSKE VYIPDEWELN REKIELIREL 1050
GQGSFGMVFE GIAHGIGDHA ELRVAVKTTN ENASIHDRIQ ILQEASIMKA 1100
FNCNHVVKLI GVVSQGQPTF VVMELMGRGD LKSYLKERRP DDGGIPLMRQ 1150
EIYQMVAEIA DGMAYLAARK FVHCDLAARN CMVASDFTVK IGDFGMARDI 1200
YERNYYRKDG KSLLPIRWMA PESLKDGIFS TASDVWSFGV VLWEICTLAS 1250
QPYQGKTNEQ VLNFVLSNGH LDYPEGCDYQ LREFMSLCWH RDPKMRPSFL 1300
EIVHVLENEV DDDFVMVSFY HEMKRKALED IYMKSESYIK SDAYTMSDGY 1350
TKGDGNMQNM LSRSQNRKSA IEKSKERLSI SSLDSGTYVE KYDANDTPEE 1400
IPKKKKRPRS KRNSAVDSNA CETKPMLRVE SLYDNHDAFS ENMQYGDTPV 1450
GKSDLMHPET NRELRLSEIF YGKPIPV 1477
Length:1,477
Mass (Da):168,278
Last modified:November 1, 1996 - v1
Checksum:i74ACDBA7C6DE1D41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64612 mRNA. Translation: AAA68205.1.
PIRiT18534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64612 mRNA. Translation: AAA68205.1 .
PIRi T18534.

3D structure databases

ProteinModelPortali Q25197.
SMRi Q25197. Positions 1022-1329.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.80.20.20. 3 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR003961. Fibronectin_type3.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
PIRSFi PIRSF000620. Insulin_receptor. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Steele R.E., Mai N.H., Lieu P., Shenk M.A.
    Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHTK7_HYDVU
AccessioniPrimary (citable) accession number: Q25197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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