Putative insulin-like peptide receptor precursor - Hydra vulgaris (Hydra)

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Q25197 (HTK7_HYDVU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 93. History...

Clusters with 100%, 90%, 50% identity |

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Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Putative insulin-like peptide receptor
EC=2.7.10.1

Gene names

Name:

HTK7

Organism

Hydra vulgaris (Hydra) (Hydra attenuata)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Cnidaria › Hydrozoa › Hydroida › Anthomedusae › Hydridae › Hydra

Protein attributes

Sequence length	1477 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Cofactor	Manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Expressed in dividing epithelial cells.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 3 fibronectin type-III domains. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological_process	protein autophosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

24

Potential

Chain

1453

Putative insulin-like peptide receptor

PRO_0000016714

Regions

Topological domain

956

Extracellular Potential

Transmembrane

21

Helical; Potential

Topological domain

476

Cytoplasmic Potential

Domain

102

Fibronectin type-III 1

Domain

81

Fibronectin type-III 2

Domain

87

Fibronectin type-III 3

Domain

272

Protein kinase

Nucleotide binding

9

ATP By similarity

Sites

Active site

1

Proton acceptor By similarity

Binding site

1

ATP By similarity

Amino acid modifications

Modified residue

1

Phosphotyrosine; by autocatalysis By similarity

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q25197 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 74ACDBA7C6DE1D41
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1,477

168,278

        10         20         30         40         50         60 
MMRNVQSFYF LFLLIVLNFH VVLSAVCIGQ RATTTIWLNQ NGDCQDVGFC QYLQNCTCWH 

        70         80         90        100        110        120 
GNLVVKSTKY YDEENFKPYF PKLREITGYL LISLCTLKFF HLFPGLTVIR GGDLILNYAL 

       130        140        150        160        170        180 
VIYYNEIKEV YFPSLTAILN GGVHIGRNHR LCYVNTIRWK SIIKDIHQTG QYGIYLESNK 

       190        200        210        220        230        240 
LNCDLGCLKG HCHPAPGHDG DPKAQYCWGP GPKKQQNKAQ CQRFCNTQCG PEGCLDGSDH 

       250        260        270        280        290        300 
ICCHHECLGG CSAINSTNTC HACRKYRIKS TGQCVSKCPR KQYLVDKFLC QESCPYWSIN 

       310        320        330        340        350        360 
STEYHHYLWQ GECVTKCPVN YISNNQTKKC EKCKSGMKCN TVCKYQDVMA DGTLYNGALI 

       370        380        390        400        410        420 
RVPSDISKKG LVGCSVFEGS LTFQLQEGTG KAEDSLNELK SLKVLKGHLK IQKSSLKSLN 

       430        440        450        460        470        480 
FLSSLEVIET PQNALLHNKY VMAVYENSQL SELWPGNESI IVSDGGIFFQ YNPRLCPLHI 

       490        500        510        520        530        540 
RNLQDRIHYK NGSKVTGEVS LQNNGHKVLC DTQMLVMHVE EFIPPDLNME TDMTAIECNS 

       550        560        570        580        590        600 
FKCVKVTWNF TMTSAYNNIL FYAIYFKELQ SNQEAVVQLD NECQNNDDWN VITVDIPKIE 

       610        620        630        640        650        660 
SLEQSLFLQS KIISKLTPYT RYAFYIKEIV SKGEERSSHI HYINISQDLP SEPLGVEASF 

       670        680        690        700        710        720 
LSENKILLKW RAPSKPNGII TAFKIYYNKP DYSFWEEQKV LDWCSRDASR DKNAKDVAGY 

       730        740        750        760        770        780 
PVNKENYNQY CNISCVCDEE KENSKAIKAD REAHNFNVEF QTELMRVLFT KNKFSYRNKN 

       790        800        810        820        830        840 
KSPPKIDFSK NISLILSNKI LTSTSTTVTQ AKIEIIEEPK VTVNGNIFSY VISGLDYFED 

       850        860        870        880        890        900 
YELKVCGCTV VGCRRPSSTI NLDCGIVQAR TGVNLTADNL DSKMVRVQVQ LDSYNISWIA 

       910        920        930        940        950        960 
PHKPNAVILK YEISIRYALD KDALVICRPG YLPTYIIRKS RFGNYVAKIR AISPAGNGSW 

       970        980        990       1000       1010       1020 
TEEIHFKVAE LSVTKNNNQL IIGIISAVSA VIVALLVFIL LYMFLHRKLE KDVQGVLYAS 

      1030       1040       1050       1060       1070       1080 
VNPEYMNSKE VYIPDEWELN REKIELIREL GQGSFGMVFE GIAHGIGDHA ELRVAVKTTN 

      1090       1100       1110       1120       1130       1140 
ENASIHDRIQ ILQEASIMKA FNCNHVVKLI GVVSQGQPTF VVMELMGRGD LKSYLKERRP 

      1150       1160       1170       1180       1190       1200 
DDGGIPLMRQ EIYQMVAEIA DGMAYLAARK FVHCDLAARN CMVASDFTVK IGDFGMARDI 

      1210       1220       1230       1240       1250       1260 
YERNYYRKDG KSLLPIRWMA PESLKDGIFS TASDVWSFGV VLWEICTLAS QPYQGKTNEQ 

      1270       1280       1290       1300       1310       1320 
VLNFVLSNGH LDYPEGCDYQ LREFMSLCWH RDPKMRPSFL EIVHVLENEV DDDFVMVSFY 

      1330       1340       1350       1360       1370       1380 
HEMKRKALED IYMKSESYIK SDAYTMSDGY TKGDGNMQNM LSRSQNRKSA IEKSKERLSI 

      1390       1400       1410       1420       1430       1440 
SSLDSGTYVE KYDANDTPEE IPKKKKRPRS KRNSAVDSNA CETKPMLRVE SLYDNHDAFS 

      1450       1460       1470 
ENMQYGDTPV GKSDLMHPET NRELRLSEIF YGKPIPV

References

[1]	Steele R.E., Mai N.H., Lieu P., Shenk M.A. Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M64612 mRNA. Translation: AAA68205.1.
PIR	T18534.
3D structure databases
ProteinModelPortal	Q25197.
SMR	Q25197. Positions 1022-1329.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR000494. EGF_rcpt_L. IPR003961. Fibronectin_type3. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt. IPR013783. Ig-like_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016246. Tyr_kinase_insulin-like_rcpt. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view]
Pfam	PF00757. Furin-like. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits. [Graphical view]
PIRSF	PIRSF000620. Insulin_receptor. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00060. FN3. 3 hits. SM00261. FU. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits. SSF57184. Grow_fac_recept. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50853. FN3. 3 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HTK7_HYDVU

Accession

Primary (citable) accession number: Q25197

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	March 6, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents