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Q25197

- HTK7_HYDVU

UniProt

Q25197 - HTK7_HYDVU

Protein

Putative insulin-like peptide receptor

Gene

HTK7

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Cofactori

    Manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1077 – 10771ATPPROSITE-ProRule annotation
    Active sitei1175 – 11751Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1050 – 10589ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein autophosphorylation Source: InterPro
    2. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative insulin-like peptide receptor (EC:2.7.10.1)
    Gene namesi
    Name:HTK7
    OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
    Taxonomic identifieri6087 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 14771453Putative insulin-like peptide receptorPRO_0000016714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi732 – 7321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1201 – 12011Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Expressioni

    Tissue specificityi

    Expressed in dividing epithelial cells.

    Structurei

    3D structure databases

    ProteinModelPortaliQ25197.
    SMRiQ25197. Positions 1022-1329.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 980956ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1002 – 1477476CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei981 – 100121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini652 – 75099Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini780 – 86990Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini880 – 97192Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1044 – 1315272Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.80.20.20. 3 hits.
    InterProiIPR000494. EGF_rcpt_L.
    IPR003961. Fibronectin_type3.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016246. Tyr_kinase_insulin-like_rcpt.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view]
    PfamiPF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000620. Insulin_receptor. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00060. FN3. 3 hits.
    SM00261. FU. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 4 hits.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS50853. FN3. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q25197-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMRNVQSFYF LFLLIVLNFH VVLSAVCIGQ RATTTIWLNQ NGDCQDVGFC     50
    QYLQNCTCWH GNLVVKSTKY YDEENFKPYF PKLREITGYL LISLCTLKFF 100
    HLFPGLTVIR GGDLILNYAL VIYYNEIKEV YFPSLTAILN GGVHIGRNHR 150
    LCYVNTIRWK SIIKDIHQTG QYGIYLESNK LNCDLGCLKG HCHPAPGHDG 200
    DPKAQYCWGP GPKKQQNKAQ CQRFCNTQCG PEGCLDGSDH ICCHHECLGG 250
    CSAINSTNTC HACRKYRIKS TGQCVSKCPR KQYLVDKFLC QESCPYWSIN 300
    STEYHHYLWQ GECVTKCPVN YISNNQTKKC EKCKSGMKCN TVCKYQDVMA 350
    DGTLYNGALI RVPSDISKKG LVGCSVFEGS LTFQLQEGTG KAEDSLNELK 400
    SLKVLKGHLK IQKSSLKSLN FLSSLEVIET PQNALLHNKY VMAVYENSQL 450
    SELWPGNESI IVSDGGIFFQ YNPRLCPLHI RNLQDRIHYK NGSKVTGEVS 500
    LQNNGHKVLC DTQMLVMHVE EFIPPDLNME TDMTAIECNS FKCVKVTWNF 550
    TMTSAYNNIL FYAIYFKELQ SNQEAVVQLD NECQNNDDWN VITVDIPKIE 600
    SLEQSLFLQS KIISKLTPYT RYAFYIKEIV SKGEERSSHI HYINISQDLP 650
    SEPLGVEASF LSENKILLKW RAPSKPNGII TAFKIYYNKP DYSFWEEQKV 700
    LDWCSRDASR DKNAKDVAGY PVNKENYNQY CNISCVCDEE KENSKAIKAD 750
    REAHNFNVEF QTELMRVLFT KNKFSYRNKN KSPPKIDFSK NISLILSNKI 800
    LTSTSTTVTQ AKIEIIEEPK VTVNGNIFSY VISGLDYFED YELKVCGCTV 850
    VGCRRPSSTI NLDCGIVQAR TGVNLTADNL DSKMVRVQVQ LDSYNISWIA 900
    PHKPNAVILK YEISIRYALD KDALVICRPG YLPTYIIRKS RFGNYVAKIR 950
    AISPAGNGSW TEEIHFKVAE LSVTKNNNQL IIGIISAVSA VIVALLVFIL 1000
    LYMFLHRKLE KDVQGVLYAS VNPEYMNSKE VYIPDEWELN REKIELIREL 1050
    GQGSFGMVFE GIAHGIGDHA ELRVAVKTTN ENASIHDRIQ ILQEASIMKA 1100
    FNCNHVVKLI GVVSQGQPTF VVMELMGRGD LKSYLKERRP DDGGIPLMRQ 1150
    EIYQMVAEIA DGMAYLAARK FVHCDLAARN CMVASDFTVK IGDFGMARDI 1200
    YERNYYRKDG KSLLPIRWMA PESLKDGIFS TASDVWSFGV VLWEICTLAS 1250
    QPYQGKTNEQ VLNFVLSNGH LDYPEGCDYQ LREFMSLCWH RDPKMRPSFL 1300
    EIVHVLENEV DDDFVMVSFY HEMKRKALED IYMKSESYIK SDAYTMSDGY 1350
    TKGDGNMQNM LSRSQNRKSA IEKSKERLSI SSLDSGTYVE KYDANDTPEE 1400
    IPKKKKRPRS KRNSAVDSNA CETKPMLRVE SLYDNHDAFS ENMQYGDTPV 1450
    GKSDLMHPET NRELRLSEIF YGKPIPV 1477
    Length:1,477
    Mass (Da):168,278
    Last modified:November 1, 1996 - v1
    Checksum:i74ACDBA7C6DE1D41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64612 mRNA. Translation: AAA68205.1.
    PIRiT18534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64612 mRNA. Translation: AAA68205.1 .
    PIRi T18534.

    3D structure databases

    ProteinModelPortali Q25197.
    SMRi Q25197. Positions 1022-1329.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.80.20.20. 3 hits.
    InterProi IPR000494. EGF_rcpt_L.
    IPR003961. Fibronectin_type3.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016246. Tyr_kinase_insulin-like_rcpt.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view ]
    Pfami PF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000620. Insulin_receptor. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00060. FN3. 3 hits.
    SM00261. FU. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 4 hits.
    SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS50853. FN3. 3 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Steele R.E., Mai N.H., Lieu P., Shenk M.A.
      Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHTK7_HYDVU
    AccessioniPrimary (citable) accession number: Q25197
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3