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Q25197

- HTK7_HYDVU

UniProt

Q25197 - HTK7_HYDVU

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Protein

Putative insulin-like peptide receptor

Gene

HTK7

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1077 – 10771ATPPROSITE-ProRule annotation
Active sitei1175 – 11751Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1050 – 10589ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein autophosphorylation Source: InterPro
  2. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative insulin-like peptide receptor (EC:2.7.10.1)
Gene namesi
Name:HTK7
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 14771453Putative insulin-like peptide receptorPRO_0000016714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi644 – 6441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi732 – 7321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi874 – 8741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis
Modified residuei1201 – 12011Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Expressed in dividing epithelial cells.

Structurei

3D structure databases

ProteinModelPortaliQ25197.
SMRiQ25197. Positions 1022-1329.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 980956ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1002 – 1477476CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei981 – 100121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini652 – 75099Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini780 – 86990Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini880 – 97192Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini1044 – 1315272Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.80.20.20. 3 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR003961. Fibronectin_type3.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000620. Insulin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q25197-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMRNVQSFYF LFLLIVLNFH VVLSAVCIGQ RATTTIWLNQ NGDCQDVGFC
60 70 80 90 100
QYLQNCTCWH GNLVVKSTKY YDEENFKPYF PKLREITGYL LISLCTLKFF
110 120 130 140 150
HLFPGLTVIR GGDLILNYAL VIYYNEIKEV YFPSLTAILN GGVHIGRNHR
160 170 180 190 200
LCYVNTIRWK SIIKDIHQTG QYGIYLESNK LNCDLGCLKG HCHPAPGHDG
210 220 230 240 250
DPKAQYCWGP GPKKQQNKAQ CQRFCNTQCG PEGCLDGSDH ICCHHECLGG
260 270 280 290 300
CSAINSTNTC HACRKYRIKS TGQCVSKCPR KQYLVDKFLC QESCPYWSIN
310 320 330 340 350
STEYHHYLWQ GECVTKCPVN YISNNQTKKC EKCKSGMKCN TVCKYQDVMA
360 370 380 390 400
DGTLYNGALI RVPSDISKKG LVGCSVFEGS LTFQLQEGTG KAEDSLNELK
410 420 430 440 450
SLKVLKGHLK IQKSSLKSLN FLSSLEVIET PQNALLHNKY VMAVYENSQL
460 470 480 490 500
SELWPGNESI IVSDGGIFFQ YNPRLCPLHI RNLQDRIHYK NGSKVTGEVS
510 520 530 540 550
LQNNGHKVLC DTQMLVMHVE EFIPPDLNME TDMTAIECNS FKCVKVTWNF
560 570 580 590 600
TMTSAYNNIL FYAIYFKELQ SNQEAVVQLD NECQNNDDWN VITVDIPKIE
610 620 630 640 650
SLEQSLFLQS KIISKLTPYT RYAFYIKEIV SKGEERSSHI HYINISQDLP
660 670 680 690 700
SEPLGVEASF LSENKILLKW RAPSKPNGII TAFKIYYNKP DYSFWEEQKV
710 720 730 740 750
LDWCSRDASR DKNAKDVAGY PVNKENYNQY CNISCVCDEE KENSKAIKAD
760 770 780 790 800
REAHNFNVEF QTELMRVLFT KNKFSYRNKN KSPPKIDFSK NISLILSNKI
810 820 830 840 850
LTSTSTTVTQ AKIEIIEEPK VTVNGNIFSY VISGLDYFED YELKVCGCTV
860 870 880 890 900
VGCRRPSSTI NLDCGIVQAR TGVNLTADNL DSKMVRVQVQ LDSYNISWIA
910 920 930 940 950
PHKPNAVILK YEISIRYALD KDALVICRPG YLPTYIIRKS RFGNYVAKIR
960 970 980 990 1000
AISPAGNGSW TEEIHFKVAE LSVTKNNNQL IIGIISAVSA VIVALLVFIL
1010 1020 1030 1040 1050
LYMFLHRKLE KDVQGVLYAS VNPEYMNSKE VYIPDEWELN REKIELIREL
1060 1070 1080 1090 1100
GQGSFGMVFE GIAHGIGDHA ELRVAVKTTN ENASIHDRIQ ILQEASIMKA
1110 1120 1130 1140 1150
FNCNHVVKLI GVVSQGQPTF VVMELMGRGD LKSYLKERRP DDGGIPLMRQ
1160 1170 1180 1190 1200
EIYQMVAEIA DGMAYLAARK FVHCDLAARN CMVASDFTVK IGDFGMARDI
1210 1220 1230 1240 1250
YERNYYRKDG KSLLPIRWMA PESLKDGIFS TASDVWSFGV VLWEICTLAS
1260 1270 1280 1290 1300
QPYQGKTNEQ VLNFVLSNGH LDYPEGCDYQ LREFMSLCWH RDPKMRPSFL
1310 1320 1330 1340 1350
EIVHVLENEV DDDFVMVSFY HEMKRKALED IYMKSESYIK SDAYTMSDGY
1360 1370 1380 1390 1400
TKGDGNMQNM LSRSQNRKSA IEKSKERLSI SSLDSGTYVE KYDANDTPEE
1410 1420 1430 1440 1450
IPKKKKRPRS KRNSAVDSNA CETKPMLRVE SLYDNHDAFS ENMQYGDTPV
1460 1470
GKSDLMHPET NRELRLSEIF YGKPIPV
Length:1,477
Mass (Da):168,278
Last modified:November 1, 1996 - v1
Checksum:i74ACDBA7C6DE1D41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64612 mRNA. Translation: AAA68205.1.
PIRiT18534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64612 mRNA. Translation: AAA68205.1 .
PIRi T18534.

3D structure databases

ProteinModelPortali Q25197.
SMRi Q25197. Positions 1022-1329.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.80.20.20. 3 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR003961. Fibronectin_type3.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
PIRSFi PIRSF000620. Insulin_receptor. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Steele R.E., Mai N.H., Lieu P., Shenk M.A.
    Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHTK7_HYDVU
AccessioniPrimary (citable) accession number: Q25197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3