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Q25197 (HTK7_HYDVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative insulin-like peptide receptor

EC=2.7.10.1
Gene names
Name:HTK7
OrganismHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifier6087 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

Protein attributes

Sequence length1477 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactor

Manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Expressed in dividing epithelial cells.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 3 fibronectin type-III domains.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 14771453Putative insulin-like peptide receptor
PRO_0000016714

Regions

Topological domain25 – 980956Extracellular Potential
Transmembrane981 – 100121Helical; Potential
Topological domain1002 – 1477476Cytoplasmic Potential
Domain652 – 75099Fibronectin type-III 1
Domain780 – 86990Fibronectin type-III 2
Domain880 – 97192Fibronectin type-III 3
Domain1044 – 1315272Protein kinase
Nucleotide binding1050 – 10589ATP By similarity

Sites

Active site11751Proton acceptor By similarity
Binding site10771ATP By similarity

Amino acid modifications

Modified residue12011Phosphotyrosine; by autocatalysis By similarity
Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation2551N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Glycosylation5491N-linked (GlcNAc...) Potential
Glycosylation6441N-linked (GlcNAc...) Potential
Glycosylation7321N-linked (GlcNAc...) Potential
Glycosylation7911N-linked (GlcNAc...) Potential
Glycosylation8741N-linked (GlcNAc...) Potential
Glycosylation8951N-linked (GlcNAc...) Potential
Glycosylation9571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q25197 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 74ACDBA7C6DE1D41

FASTA1,477168,278
        10         20         30         40         50         60 
MMRNVQSFYF LFLLIVLNFH VVLSAVCIGQ RATTTIWLNQ NGDCQDVGFC QYLQNCTCWH 

        70         80         90        100        110        120 
GNLVVKSTKY YDEENFKPYF PKLREITGYL LISLCTLKFF HLFPGLTVIR GGDLILNYAL 

       130        140        150        160        170        180 
VIYYNEIKEV YFPSLTAILN GGVHIGRNHR LCYVNTIRWK SIIKDIHQTG QYGIYLESNK 

       190        200        210        220        230        240 
LNCDLGCLKG HCHPAPGHDG DPKAQYCWGP GPKKQQNKAQ CQRFCNTQCG PEGCLDGSDH 

       250        260        270        280        290        300 
ICCHHECLGG CSAINSTNTC HACRKYRIKS TGQCVSKCPR KQYLVDKFLC QESCPYWSIN 

       310        320        330        340        350        360 
STEYHHYLWQ GECVTKCPVN YISNNQTKKC EKCKSGMKCN TVCKYQDVMA DGTLYNGALI 

       370        380        390        400        410        420 
RVPSDISKKG LVGCSVFEGS LTFQLQEGTG KAEDSLNELK SLKVLKGHLK IQKSSLKSLN 

       430        440        450        460        470        480 
FLSSLEVIET PQNALLHNKY VMAVYENSQL SELWPGNESI IVSDGGIFFQ YNPRLCPLHI 

       490        500        510        520        530        540 
RNLQDRIHYK NGSKVTGEVS LQNNGHKVLC DTQMLVMHVE EFIPPDLNME TDMTAIECNS 

       550        560        570        580        590        600 
FKCVKVTWNF TMTSAYNNIL FYAIYFKELQ SNQEAVVQLD NECQNNDDWN VITVDIPKIE 

       610        620        630        640        650        660 
SLEQSLFLQS KIISKLTPYT RYAFYIKEIV SKGEERSSHI HYINISQDLP SEPLGVEASF 

       670        680        690        700        710        720 
LSENKILLKW RAPSKPNGII TAFKIYYNKP DYSFWEEQKV LDWCSRDASR DKNAKDVAGY 

       730        740        750        760        770        780 
PVNKENYNQY CNISCVCDEE KENSKAIKAD REAHNFNVEF QTELMRVLFT KNKFSYRNKN 

       790        800        810        820        830        840 
KSPPKIDFSK NISLILSNKI LTSTSTTVTQ AKIEIIEEPK VTVNGNIFSY VISGLDYFED 

       850        860        870        880        890        900 
YELKVCGCTV VGCRRPSSTI NLDCGIVQAR TGVNLTADNL DSKMVRVQVQ LDSYNISWIA 

       910        920        930        940        950        960 
PHKPNAVILK YEISIRYALD KDALVICRPG YLPTYIIRKS RFGNYVAKIR AISPAGNGSW 

       970        980        990       1000       1010       1020 
TEEIHFKVAE LSVTKNNNQL IIGIISAVSA VIVALLVFIL LYMFLHRKLE KDVQGVLYAS 

      1030       1040       1050       1060       1070       1080 
VNPEYMNSKE VYIPDEWELN REKIELIREL GQGSFGMVFE GIAHGIGDHA ELRVAVKTTN 

      1090       1100       1110       1120       1130       1140 
ENASIHDRIQ ILQEASIMKA FNCNHVVKLI GVVSQGQPTF VVMELMGRGD LKSYLKERRP 

      1150       1160       1170       1180       1190       1200 
DDGGIPLMRQ EIYQMVAEIA DGMAYLAARK FVHCDLAARN CMVASDFTVK IGDFGMARDI 

      1210       1220       1230       1240       1250       1260 
YERNYYRKDG KSLLPIRWMA PESLKDGIFS TASDVWSFGV VLWEICTLAS QPYQGKTNEQ 

      1270       1280       1290       1300       1310       1320 
VLNFVLSNGH LDYPEGCDYQ LREFMSLCWH RDPKMRPSFL EIVHVLENEV DDDFVMVSFY 

      1330       1340       1350       1360       1370       1380 
HEMKRKALED IYMKSESYIK SDAYTMSDGY TKGDGNMQNM LSRSQNRKSA IEKSKERLSI 

      1390       1400       1410       1420       1430       1440 
SSLDSGTYVE KYDANDTPEE IPKKKKRPRS KRNSAVDSNA CETKPMLRVE SLYDNHDAFS 

      1450       1460       1470 
ENMQYGDTPV GKSDLMHPET NRELRLSEIF YGKPIPV 

« Hide

References

[1]Steele R.E., Mai N.H., Lieu P., Shenk M.A.
Submitted (APR-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64612 mRNA. Translation: AAA68205.1.
PIRT18534.

3D structure databases

ProteinModelPortalQ25197.
SMRQ25197. Positions 1022-1329.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.10. 4 hits.
3.80.20.20. 3 hits.
InterProIPR000494. EGF_rcpt_L.
IPR003961. Fibronectin_type3.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFPIRSF000620. Insulin_receptor. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 4 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEPS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHTK7_HYDVU
AccessionPrimary (citable) accession number: Q25197
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families