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Protein

Putative insulin-like peptide receptor

Gene

HTK7

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1077ATPPROSITE-ProRule annotation1
Active sitei1175Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1050 – 1058ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative insulin-like peptide receptor (EC:2.7.10.1)
Gene namesi
Name:HTK7
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 980ExtracellularSequence analysisAdd BLAST956
Transmembranei981 – 1001HelicalSequence analysisAdd BLAST21
Topological domaini1002 – 1477CytoplasmicSequence analysisAdd BLAST476

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001671425 – 1477Putative insulin-like peptide receptorAdd BLAST1453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1
Glycosylationi549N-linked (GlcNAc...)Sequence analysis1
Glycosylationi644N-linked (GlcNAc...)Sequence analysis1
Glycosylationi732N-linked (GlcNAc...)Sequence analysis1
Glycosylationi791N-linked (GlcNAc...)Sequence analysis1
Glycosylationi874N-linked (GlcNAc...)Sequence analysis1
Glycosylationi895N-linked (GlcNAc...)Sequence analysis1
Glycosylationi957N-linked (GlcNAc...)Sequence analysis1
Modified residuei1201Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Expressed in dividing epithelial cells.

Structurei

3D structure databases

ProteinModelPortaliQ25197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini652 – 750Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini780 – 869Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini880 – 971Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST92
Domaini1044 – 1315Protein kinasePROSITE-ProRule annotationAdd BLAST272

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK05087.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
3.80.20.20. 3 hits.
InterProiIPR003961. FN3_dom.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000620. Insulin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
SSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q25197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRNVQSFYF LFLLIVLNFH VVLSAVCIGQ RATTTIWLNQ NGDCQDVGFC
60 70 80 90 100
QYLQNCTCWH GNLVVKSTKY YDEENFKPYF PKLREITGYL LISLCTLKFF
110 120 130 140 150
HLFPGLTVIR GGDLILNYAL VIYYNEIKEV YFPSLTAILN GGVHIGRNHR
160 170 180 190 200
LCYVNTIRWK SIIKDIHQTG QYGIYLESNK LNCDLGCLKG HCHPAPGHDG
210 220 230 240 250
DPKAQYCWGP GPKKQQNKAQ CQRFCNTQCG PEGCLDGSDH ICCHHECLGG
260 270 280 290 300
CSAINSTNTC HACRKYRIKS TGQCVSKCPR KQYLVDKFLC QESCPYWSIN
310 320 330 340 350
STEYHHYLWQ GECVTKCPVN YISNNQTKKC EKCKSGMKCN TVCKYQDVMA
360 370 380 390 400
DGTLYNGALI RVPSDISKKG LVGCSVFEGS LTFQLQEGTG KAEDSLNELK
410 420 430 440 450
SLKVLKGHLK IQKSSLKSLN FLSSLEVIET PQNALLHNKY VMAVYENSQL
460 470 480 490 500
SELWPGNESI IVSDGGIFFQ YNPRLCPLHI RNLQDRIHYK NGSKVTGEVS
510 520 530 540 550
LQNNGHKVLC DTQMLVMHVE EFIPPDLNME TDMTAIECNS FKCVKVTWNF
560 570 580 590 600
TMTSAYNNIL FYAIYFKELQ SNQEAVVQLD NECQNNDDWN VITVDIPKIE
610 620 630 640 650
SLEQSLFLQS KIISKLTPYT RYAFYIKEIV SKGEERSSHI HYINISQDLP
660 670 680 690 700
SEPLGVEASF LSENKILLKW RAPSKPNGII TAFKIYYNKP DYSFWEEQKV
710 720 730 740 750
LDWCSRDASR DKNAKDVAGY PVNKENYNQY CNISCVCDEE KENSKAIKAD
760 770 780 790 800
REAHNFNVEF QTELMRVLFT KNKFSYRNKN KSPPKIDFSK NISLILSNKI
810 820 830 840 850
LTSTSTTVTQ AKIEIIEEPK VTVNGNIFSY VISGLDYFED YELKVCGCTV
860 870 880 890 900
VGCRRPSSTI NLDCGIVQAR TGVNLTADNL DSKMVRVQVQ LDSYNISWIA
910 920 930 940 950
PHKPNAVILK YEISIRYALD KDALVICRPG YLPTYIIRKS RFGNYVAKIR
960 970 980 990 1000
AISPAGNGSW TEEIHFKVAE LSVTKNNNQL IIGIISAVSA VIVALLVFIL
1010 1020 1030 1040 1050
LYMFLHRKLE KDVQGVLYAS VNPEYMNSKE VYIPDEWELN REKIELIREL
1060 1070 1080 1090 1100
GQGSFGMVFE GIAHGIGDHA ELRVAVKTTN ENASIHDRIQ ILQEASIMKA
1110 1120 1130 1140 1150
FNCNHVVKLI GVVSQGQPTF VVMELMGRGD LKSYLKERRP DDGGIPLMRQ
1160 1170 1180 1190 1200
EIYQMVAEIA DGMAYLAARK FVHCDLAARN CMVASDFTVK IGDFGMARDI
1210 1220 1230 1240 1250
YERNYYRKDG KSLLPIRWMA PESLKDGIFS TASDVWSFGV VLWEICTLAS
1260 1270 1280 1290 1300
QPYQGKTNEQ VLNFVLSNGH LDYPEGCDYQ LREFMSLCWH RDPKMRPSFL
1310 1320 1330 1340 1350
EIVHVLENEV DDDFVMVSFY HEMKRKALED IYMKSESYIK SDAYTMSDGY
1360 1370 1380 1390 1400
TKGDGNMQNM LSRSQNRKSA IEKSKERLSI SSLDSGTYVE KYDANDTPEE
1410 1420 1430 1440 1450
IPKKKKRPRS KRNSAVDSNA CETKPMLRVE SLYDNHDAFS ENMQYGDTPV
1460 1470
GKSDLMHPET NRELRLSEIF YGKPIPV
Length:1,477
Mass (Da):168,278
Last modified:November 1, 1996 - v1
Checksum:i74ACDBA7C6DE1D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64612 mRNA. Translation: AAA68205.1.
PIRiT18534.
RefSeqiNP_001296700.1. NM_001309771.1.

Genome annotation databases

GeneIDi100214733.
KEGGihmg:100214733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64612 mRNA. Translation: AAA68205.1.
PIRiT18534.
RefSeqiNP_001296700.1. NM_001309771.1.

3D structure databases

ProteinModelPortaliQ25197.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100214733.
KEGGihmg:100214733.

Phylogenomic databases

KOiK05087.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 4 hits.
3.80.20.20. 3 hits.
InterProiIPR003961. FN3_dom.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000620. Insulin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
SSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTK7_HYDVU
AccessioniPrimary (citable) accession number: Q25197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.