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Protein

Sodium channel protein

Gene

TuNaI

Organism
Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:TuNaIImported
OrganismiHalocynthia roretzi (Sea squirt) (Cynthia roretzi)Imported
Taxonomic identifieri7729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaPyuridaeHalocynthia

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei127 – 150HelicalUniRule annotationAdd BLAST24
Transmembranei162 – 186HelicalUniRule annotationAdd BLAST25
Transmembranei192 – 210HelicalUniRule annotationAdd BLAST19
Transmembranei239 – 257HelicalUniRule annotationAdd BLAST19
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei441 – 469HelicalUniRule annotationAdd BLAST29
Transmembranei921 – 943HelicalUniRule annotationAdd BLAST23
Transmembranei965 – 985HelicalUniRule annotationAdd BLAST21
Transmembranei997 – 1022HelicalUniRule annotationAdd BLAST26
Transmembranei1261 – 1280HelicalUniRule annotationAdd BLAST20
Transmembranei1301 – 1317HelicalUniRule annotationAdd BLAST17
Transmembranei1329 – 1349HelicalUniRule annotationAdd BLAST21
Transmembranei1378 – 1404HelicalUniRule annotationAdd BLAST27
Transmembranei1512 – 1536HelicalUniRule annotationAdd BLAST25
Transmembranei1586 – 1608HelicalUniRule annotationAdd BLAST23
Transmembranei1628 – 1647HelicalUniRule annotationAdd BLAST20
Transmembranei1659 – 1675HelicalUniRule annotationAdd BLAST17
Transmembranei1712 – 1740HelicalUniRule annotationAdd BLAST29
Transmembranei1816 – 1839HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ25150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 475Ion_transInterPro annotationAdd BLAST346
Domaini799 – 1025Ion_transInterPro annotationAdd BLAST227
Domaini1036 – 1256Na_trans_assocInterPro annotationAdd BLAST221
Domaini1260 – 1545Ion_transInterPro annotationAdd BLAST286
Domaini1593 – 1849Ion_transInterPro annotationAdd BLAST257

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG053100.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q25150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTDLLDIS IEPLTLEYLR NIDNIPIKSR DRTISNSSKR KGSDNVATPK
60 70 80 90 100
LHPNPDLEQG KTLPEYLQGD LPDKYLCQAL VDPDPFYANK KTYVVFDKNK
110 120 130 140 150
VIYRFSCEKA LFCLGPLNPV RRIANMIYIH SVFNSVIMLT ILVNCGFMAY
160 170 180 190 200
GEDVDIVEKT FLAIYTFEAV VKIFSRGFIL SSFTYLRDPW NILDISVIFT
210 220 230 240 250
AYLDIVMALA QKASDGGKAQ KIPGMAALRA FRVLRALKAI SAIPGLKAIV
260 270 280 290 300
AALIESVKAL KDVMILTLFC LSVFALIGLQ LFMGSLRNKC IRQWPPYVND
310 320 330 340 350
ELMTMWLTQN YTDFNHSNPL VYLGNLTQVI KPEISVAKPM PCDPNPACNE
360 370 380 390 400
TTIWFNQTWE NWMENECNYC FVRGAAWLCG NGTDTGKCWE GYECVLTGEN
410 420 430 440 450
PNFGYTSFDN FSWAFLSLFR LMAQDYWENL YQLTLRANGK VYLIFFMVVI
460 470 480 490 500
FLGSFYLINL ILAVVAMAYE EQHQLVAMEE ERKTALMQKK REEIDALLTE
510 520 530 540 550
VHDAEMKLES RRASVVCTDS SPASSAGSLL SMYRRKSLVI NVESGRACGR
560 570 580 590 600
QTSVKSISKA GHHNGNLTKT PFSDILIGTE TISVDSKTSS VSFSLKNEAP
610 620 630 640 650
PTGRRQTNPQ IPEIVVNSFT SPHTPSQEFD GEELSKRIQE ELNRQRSQPQ
660 670 680 690 700
FQSKFTNLDG HYNSGTVVDR NGAVTLAQTT EHPTGGPHIS VLLPEVIIES
710 720 730 740 750
AHDSEAGSRS PDCEMICMDS LKPYSRSRAT SIDLLGEPEL AMLKKRAMSQ
760 770 780 790 800
ASIMTAELDR QDRKCSPCWY KFTNIFCIWN CCGAWNYIHK ICKIICEDPF
810 820 830 840 850
LDLFITICII VNTAFMTAEY QPMEESYARI LEVANLVFTV IFTAEMVLKV
860 870 880 890 900
VGMQPFQYFQ DPWNCFDSVI VSFSLLEYAL QSVGGLSVLR TFRLMRVFKL
910 920 930 940 950
AKSWPTLNML IKIIGNSMGS LGNLTLILII VLFIFAVVGM QLFRERYKEA
960 970 980 990 1000
ELAGNLNMRW HMKDFGHSFL IVFRILCGEW IETMWDCLRW GGDIRGLCVP
1010 1020 1030 1040 1050
VFLLVQVVGN LVVLNLFLAL LLSSFLADNF VNEEEEPNAI QLSMIRVNKF
1060 1070 1080 1090 1100
LAIAKVKVNA AKATLLESCR KKLVIGLDSK LMTQPHCNDI NRDRMANTGN
1110 1120 1130 1140 1150
GLADGQKIVY NAPINQNEKP MTEKPKICFE TTESVPIKHR KSNTLAVTWS
1160 1170 1180 1190 1200
PSKMKVPRAD GESDFEVPDS DEQSLDDESD YMSSVRSSRS GTLSMDSRSD
1210 1220 1230 1240 1250
FEGVETSLPE KNTEEEEDVP SPCWPDKWKE RVACCDPVVD EGLCLVWWNM
1260 1270 1280 1290 1300
RKICYRIIEH AWFESFIILM IMLSSGALAF EDVYLKDKIG LQRVLKYADR
1310 1320 1330 1340 1350
IFTYVFIFEM LLKWVGYGFK KYFTNAWCWL DFLIVGVSLI SLIAEALGMD
1360 1370 1380 1390 1400
QIGSIRSLRT LRALRPLRAM SRFRGMKVVV NALVGAIPSI FNVLLVCLIF
1410 1420 1430 1440 1450
WLIFSIMGVN FFAGKFRKCL NTTSGISLPA ENFTLYGVTY PEINSTVCKY
1460 1470 1480 1490 1500
IHENVTQDIM WRNSKINFDN AFSGYLALLQ VATYKGWMEI MYDAVDVTYT
1510 1520 1530 1540 1550
NKQPKFENSV GYYFYFVAFI LFGSFFTLNL FIGVIIDNFS QQKKKLGGQD
1560 1570 1580 1590 1600
IFMTEEQRKY YNAMKKLGSK QPQKPVPRPK NELQAWVFDI VVHQTFEIAI
1610 1620 1630 1640 1650
MILIVTNMFT MMIEYHDMPK NLMDVLEYIN YVFIAIFTGE CLLKWCALRF
1660 1670 1680 1690 1700
YYFKNPWNVF DFIVVILSVV GSTMNEVIKQ YFLQPTLFRI IRLARIGRIL
1710 1720 1730 1740 1750
RLIRGAKGIR TLLFALMMSL PALFNIALLL VLVMFIYSIF GMSQFAYVHR
1760 1770 1780 1790 1800
GDGIDDIFNF ETFPNSFLCL FMITTSAGWA GLLSPIMDSD APDCNILLQN
1810 1820 1830 1840 1850
DNPNGRGDCG NPKIGIIFFV TYLIMTFLIV VNMYIAIILE NFGVATEESA
1860 1870 1880 1890 1900
DPLGEDDFEM FYEIWERFDP KATQFIAYEH LSDFVDNLDL PLKVPKPNFD
1910 1920 1930 1940 1950
TLIAMDLPMV MGDRLHCLDV LFALTKRVLG ESDALEGLRS QMEDKFMEAN
1960 1970 1980 1990 2000
PSKVSYEPIT TTLRRKQEEM SAVIIQRSWR RYRIRHAVHT ASRLFLGLNL
2010 2020 2030 2040
LHDDPFENST QETVNNDSLH PDFLHQDATS SNYDRRTSAG FLAEENTYS
Length:2,049
Mass (Da):233,445
Last modified:November 1, 1996 - v1
Checksum:iF7DE3578105B73FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17311 mRNA. Translation: BAA04133.1.
PIRiT43161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17311 mRNA. Translation: BAA04133.1.
PIRiT43161.

3D structure databases

ProteinModelPortaliQ25150.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG053100.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ25150_HALRO
AccessioniPrimary (citable) accession number: Q25150
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.