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Protein

Aquaporin

Gene
N/A
Organism
Haematobia irritans exigua (Buffalo fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin
Alternative name(s):
BfWC1
Water channel 1
OrganismiHaematobia irritans exigua (Buffalo fly)
Taxonomic identifieri34678 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeHaematobia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 46Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini47 – 56ExtracellularSequence analysis10
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 99CytoplasmicSequence analysisAdd BLAST22
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 138ExtracellularSequence analysisAdd BLAST18
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 169CytoplasmicSequence analysis10
Transmembranei170 – 190Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini191 – 211ExtracellularSequence analysisAdd BLAST21
Transmembranei212 – 232Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini233 – 251CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639771 – 251AquaporinAdd BLAST251

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ25074.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 83NPA 13
Motifi198 – 200NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q25074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEKLDMSAV VGVKDITDNK KIWRQLMAEL IGTFFLVVIG VGSCTGGSEW
60 70 80 90 100
SPSIPQIAFT FGLTVATLAQ AIGHISGCHI NPAVTVGFLI VGEMSIIKSV
110 120 130 140 150
LYIAVQCVGA IAGAAVIKVG VSEAVSGLDL GVSSFSSTLT VGQAVLIEAL
160 170 180 190 200
ITFILVVVVK GVSDPGRTDI KGSAPLAVGL SIAAGHLCAI KLTGASMNPA
210 220 230 240 250
RSFGPAVVQN MWIDHWVYWV GPIVGAIVAA LLYKFVFKVR KGDDEANSYD

F
Length:251
Mass (Da):26,166
Last modified:November 1, 1996 - v1
Checksum:iCC158C8BC378DF79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51638 mRNA. Translation: AAA96783.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51638 mRNA. Translation: AAA96783.1.

3D structure databases

ProteinModelPortaliQ25074.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQP_HAEIX
AccessioniPrimary (citable) accession number: Q25074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.