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Protein

Aquaporin

Gene
N/A
Organism
Haematobia irritans exigua (Buffalo fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Forms a water-specific channel.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin
Alternative name(s):
BfWC1
Water channel 1
OrganismiHaematobia irritans exigua (Buffalo fly)
Taxonomic identifieri34678 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeHaematobia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence analysisAdd
BLAST
Transmembranei27 – 4620Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 5610ExtracellularSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9922CytoplasmicSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13818ExtracellularSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 16910CytoplasmicSequence analysis
Transmembranei170 – 19021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini191 – 21121ExtracellularSequence analysisAdd
BLAST
Transmembranei212 – 23221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini233 – 25119CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251AquaporinPRO_0000063977Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ25074.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 833NPA 1
Motifi198 – 2003NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q25074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEKLDMSAV VGVKDITDNK KIWRQLMAEL IGTFFLVVIG VGSCTGGSEW
60 70 80 90 100
SPSIPQIAFT FGLTVATLAQ AIGHISGCHI NPAVTVGFLI VGEMSIIKSV
110 120 130 140 150
LYIAVQCVGA IAGAAVIKVG VSEAVSGLDL GVSSFSSTLT VGQAVLIEAL
160 170 180 190 200
ITFILVVVVK GVSDPGRTDI KGSAPLAVGL SIAAGHLCAI KLTGASMNPA
210 220 230 240 250
RSFGPAVVQN MWIDHWVYWV GPIVGAIVAA LLYKFVFKVR KGDDEANSYD

F
Length:251
Mass (Da):26,166
Last modified:November 1, 1996 - v1
Checksum:iCC158C8BC378DF79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51638 mRNA. Translation: AAA96783.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51638 mRNA. Translation: AAA96783.1.

3D structure databases

ProteinModelPortaliQ25074.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression in Escherichia coli of an aquaporin-like gene from adult buffalo fly (Haematobia irritans exigua)."
    Elvin C.M., Bunch R., Liyou N.E., Pearson R.D., Gough J., Drinkwater R.D.
    Insect Mol. Biol. 8:369-380(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAQP_HAEIX
AccessioniPrimary (citable) accession number: Q25074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.