Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q24ZZ8

- FTHS2_DESHY

UniProt

Q24ZZ8 - FTHS2_DESHY

Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDHAF138119:GHT5-630-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 2UniRule annotation
    Short name:
    FHS 2UniRule annotation
    Short name:
    FTHFS 2UniRule annotation
    Gene namesi
    Name:fhs2UniRule annotation
    Ordered Locus Names:DSY0605
    OrganismiDesulfitobacterium hafniense (strain Y51)
    Taxonomic identifieri138119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
    ProteomesiUP000001946: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligase 2PRO_0000293035Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi138119.DSY0605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24ZZ8.
    SMRiQ24ZZ8. Positions 6-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiQLRYIND.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q24ZZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFKSDIEIA QESTMLPVAE LAEKLNIAEE YVESYGKYKA KIDYNLLKEK    50
    GNTPDGKLIL VTAINPTPAG EGKTTTTVGL GDALTHLGKK VVIALREPSL 100
    GPVFGVKGGA AGGGYAQVVP MEDINLHFTG DLHAIGAANN LIAALLDNHI 150
    YQGNALDIDV RRITWKRCMD MNDRQLRYIN DGLGGKANGM PREDGFDITV 200
    ASEIMAILCL SSDLDDLKQR VERIIVGYNR KGEPVTAGQL KAQGAVAALL 250
    KDALKPNLVQ TLEHTPSFIH GGPFANIAHG CNSVMATKMA LKLGDYVVTE 300
    AGFGADLGAE KFLDIKCRLS GLEPDAVVIV ATVRALKSHG GVAKADLNQE 350
    NLAALKEGLP NLLKHVENIT VNFGLPAVVA INRFPTDTLA EVQLVEEECK 400
    KLGVNVALSE VWEKGGAGGV ELAEEVLKLM DSPKNFTFAY DIDLGLKEKI 450
    TAIATKIYGA DGVDFIGSST KDIEGIESIG YRNIPVCMAK TQYSLSDDQK 500
    KLGRPTGFRI SIRSVKVSAG AGFAVALTGD IMTMPGLPKV PAAESIDVDN 550
    TGRISGLF 558
    Length:558
    Mass (Da):59,457
    Last modified:April 18, 2006 - v1
    Checksum:i71991F4502367679
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE82394.1.
    RefSeqiYP_516838.1. NC_007907.1.

    Genome annotation databases

    EnsemblBacteriaiBAE82394; BAE82394; DSY0605.
    GeneIDi3954183.
    KEGGidsy:DSY0605.
    PATRICi21669421. VBIDesHaf65307_0679.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE82394.1 .
    RefSeqi YP_516838.1. NC_007907.1.

    3D structure databases

    ProteinModelPortali Q24ZZ8.
    SMRi Q24ZZ8. Positions 6-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 138119.DSY0605.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE82394 ; BAE82394 ; DSY0605 .
    GeneIDi 3954183.
    KEGGi dsy:DSY0605.
    PATRICi 21669421. VBIDesHaf65307_0679.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi QLRYIND.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DHAF138119:GHT5-630-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
      Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
      J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y51.

    Entry informationi

    Entry nameiFTHS2_DESHY
    AccessioniPrimary (citable) accession number: Q24ZZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3