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Q24ZZ8

- FTHS2_DESHY

UniProt

Q24ZZ8 - FTHS2_DESHY

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Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDHAF138119:GHT5-630-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 2UniRule annotation
Short name:
FHS 2UniRule annotation
Short name:
FTHFS 2UniRule annotation
Gene namesi
Name:fhs2UniRule annotation
Ordered Locus Names:DSY0605
OrganismiDesulfitobacterium hafniense (strain Y51)
Taxonomic identifieri138119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000001946: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligase 2PRO_0000293035Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi138119.DSY0605.

Structurei

3D structure databases

ProteinModelPortaliQ24ZZ8.
SMRiQ24ZZ8. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiQLRYIND.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24ZZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFKSDIEIA QESTMLPVAE LAEKLNIAEE YVESYGKYKA KIDYNLLKEK
60 70 80 90 100
GNTPDGKLIL VTAINPTPAG EGKTTTTVGL GDALTHLGKK VVIALREPSL
110 120 130 140 150
GPVFGVKGGA AGGGYAQVVP MEDINLHFTG DLHAIGAANN LIAALLDNHI
160 170 180 190 200
YQGNALDIDV RRITWKRCMD MNDRQLRYIN DGLGGKANGM PREDGFDITV
210 220 230 240 250
ASEIMAILCL SSDLDDLKQR VERIIVGYNR KGEPVTAGQL KAQGAVAALL
260 270 280 290 300
KDALKPNLVQ TLEHTPSFIH GGPFANIAHG CNSVMATKMA LKLGDYVVTE
310 320 330 340 350
AGFGADLGAE KFLDIKCRLS GLEPDAVVIV ATVRALKSHG GVAKADLNQE
360 370 380 390 400
NLAALKEGLP NLLKHVENIT VNFGLPAVVA INRFPTDTLA EVQLVEEECK
410 420 430 440 450
KLGVNVALSE VWEKGGAGGV ELAEEVLKLM DSPKNFTFAY DIDLGLKEKI
460 470 480 490 500
TAIATKIYGA DGVDFIGSST KDIEGIESIG YRNIPVCMAK TQYSLSDDQK
510 520 530 540 550
KLGRPTGFRI SIRSVKVSAG AGFAVALTGD IMTMPGLPKV PAAESIDVDN

TGRISGLF
Length:558
Mass (Da):59,457
Last modified:April 18, 2006 - v1
Checksum:i71991F4502367679
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008230 Genomic DNA. Translation: BAE82394.1.
RefSeqiYP_516838.1. NC_007907.1.

Genome annotation databases

EnsemblBacteriaiBAE82394; BAE82394; DSY0605.
GeneIDi3954183.
KEGGidsy:DSY0605.
PATRICi21669421. VBIDesHaf65307_0679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008230 Genomic DNA. Translation: BAE82394.1 .
RefSeqi YP_516838.1. NC_007907.1.

3D structure databases

ProteinModelPortali Q24ZZ8.
SMRi Q24ZZ8. Positions 6-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 138119.DSY0605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE82394 ; BAE82394 ; DSY0605 .
GeneIDi 3954183.
KEGGi dsy:DSY0605.
PATRICi 21669421. VBIDesHaf65307_0679.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi QLRYIND.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DHAF138119:GHT5-630-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
    Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
    J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y51.

Entry informationi

Entry nameiFTHS2_DESHY
AccessioniPrimary (citable) accession number: Q24ZZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 18, 2006
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3