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Q24ZG8

- ASSY_DESHY

UniProt

Q24ZG8 - ASSY_DESHY

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei93 – 931CitrullineUniRule annotation
Binding sitei98 – 981CitrullineUniRule annotation
Binding sitei123 – 1231ATP; via amide nitrogenUniRule annotation
Binding sitei125 – 1251AspartateUniRule annotation
Binding sitei129 – 1291AspartateUniRule annotation
Binding sitei129 – 1291CitrullineUniRule annotation
Binding sitei130 – 1301AspartateUniRule annotation
Binding sitei133 – 1331CitrullineUniRule annotation
Binding sitei182 – 1821CitrullineUniRule annotation
Binding sitei191 – 1911CitrullineUniRule annotation
Binding sitei267 – 2671CitrullineUniRule annotation
Binding sitei279 – 2791CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDHAF138119:GHT5-810-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:DSY0785
OrganismiDesulfitobacterium hafniense (strain Y51)
Taxonomic identifieri138119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000001946: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Argininosuccinate synthasePRO_0000263921Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi138119.DSY0785.

Structurei

3D structure databases

ProteinModelPortaliQ24ZG8.
SMRiQ24ZG8. Positions 11-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24ZG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRKEVIPMK KVVLAYSGGL DTSIIIPWLK ENYGYEVIAM AADLGQGEEL
60 70 80 90 100
EPLHEKAIKS GASKLYIEDL QEEFVTDFIY PTLKAGAVYE GKYLLGTSFA
110 120 130 140 150
RPLIAQRLVE IAAKEGAVAI AHGATGKGND QVRFELAVKA LNPDLEIIAP
160 170 180 190 200
WRIWDIKSRE DAIDYAVERG IPVPVTKDRP YSMDRNVWHL SHEGGDLEDP
210 220 230 240 250
WNEPKKDLYL LGVSPEDAPD EAEYLELDFE QGIPVSLNGE KLGPVQLLET
260 270 280 290 300
LNEVGGKHGI GIVDMVENRL VGMKSRGVYE TPGGTILYTA HQALEHLTLD
310 320 330 340 350
RLTLHYKEQI ALKYAELVYD GVWHSPLREA LDAFVDVTQK NVTGTVRLKL
360 370 380 390 400
YKGNCSLAGV KSPYSLYSEE FATFGRDGVY NQKDAEGFIN LFGLPLKVRA

LMEKKSGLR
Length:409
Mass (Da):45,535
Last modified:April 18, 2006 - v1
Checksum:iDE018F6449827761
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008230 Genomic DNA. Translation: BAE82574.1.
RefSeqiYP_517018.1. NC_007907.1.

Genome annotation databases

EnsemblBacteriaiBAE82574; BAE82574; DSY0785.
GeneIDi3954984.
KEGGidsy:DSY0785.
PATRICi21669835. VBIDesHaf65307_0887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008230 Genomic DNA. Translation: BAE82574.1 .
RefSeqi YP_517018.1. NC_007907.1.

3D structure databases

ProteinModelPortali Q24ZG8.
SMRi Q24ZG8. Positions 11-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 138119.DSY0785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE82574 ; BAE82574 ; DSY0785 .
GeneIDi 3954984.
KEGGi dsy:DSY0785.
PATRICi 21669835. VBIDesHaf65307_0887.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci DHAF138119:GHT5-810-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
    Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
    J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y51.

Entry informationi

Entry nameiASSY_DESHY
AccessioniPrimary (citable) accession number: Q24ZG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3