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Protein

Catalase-peroxidase

Gene

katG

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei92Transition state stabilizerUniRule annotation1
Active sitei96Proton acceptorUniRule annotation1
Metal bindingi259Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3653. DhaCP01_Y51.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:DSY1012
OrganismiDesulfitobacterium hafniense (strain Y51)
Taxonomic identifieri138119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
Proteomesi
  • UP000001946 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547671 – 730Catalase-peroxidaseAdd BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki95 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ24YU1.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi138119.DSY1012.

Structurei

3D structure databases

ProteinModelPortaliQ24YU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24YU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKKCPVTG HTQHTPTGGG TKNKDWWPNQ LNLNILHQNS ALGNPMDPDF
60 70 80 90 100
NYAEEFKKLD LAAVKKDLYA LMTDSQDWWP ADYGHYGPLF IRMAWHSAGT
110 120 130 140 150
YRLNDGRGGA GDGTQRFAPL NSWPDNVNLD KARRLLWPIK QKYGKKISWA
160 170 180 190 200
DLMVLAGNCA LESMGFKTFG FAGGREDVWE PQEDIYWGSE GEWLGDQRYS
210 220 230 240 250
GDRDLENPLA AVQMGLIYVN PEGPNGQPSV LASGRDVRDT FKRMAMNDEE
260 270 280 290 300
TVALVAGGHT FGKCHGAGPA SHVGPEPEAA PLEEQGLGWK STFRSGKGGD
310 320 330 340 350
TIGSGIEGAW KPNPTTWDMG YLETLFKYDW DLVKSPAGAW QWVPTDPAAA
360 370 380 390 400
DTVQDAHDPA KRHAPMMTTA DLSLRMDPIF GPIAKRFRDN PEEFADAFAR
410 420 430 440 450
AWFKLTHRDM GPRSRYLGPE VPEEELIWQD PVPPVDHELI DEQDIADLKA
460 470 480 490 500
KLLASGLSVS QLVSTAWASA STFRGSDKRG GANGARIRLA PQKDWEINQP
510 520 530 540 550
AQLAEVLAAL EGIQTEFNSS QSGTKKVSLA DLIVLGGAAA IEQAARNAGH
560 570 580 590 600
TLVLPFTPGR TDATQEQTEI YSFAVMEPKA DGFRNYLKGK SSAPAEEMLV
610 620 630 640 650
DRAQLLTLTA PEMTVLLGGL RVLNANYGQS KHGVFTQRPE TLTNDFFVNL
660 670 680 690 700
LDMGTEWKAV SEEKALYEGR DRATGELKWT GTRVDLVFGS NSQLRALAEV
710 720 730
YACSDSQDKF LQDFVSAWNK VMNADRFDLA
Length:730
Mass (Da):80,533
Last modified:April 18, 2006 - v1
Checksum:i1345E2AFC4F51603
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008230 Genomic DNA. Translation: BAE82801.1.
RefSeqiWP_005814129.1. NC_007907.1.

Genome annotation databases

EnsemblBacteriaiBAE82801; BAE82801; DSY1012.
KEGGidsy:DSY1012.
PATRICi21670328. VBIDesHaf65307_1131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008230 Genomic DNA. Translation: BAE82801.1.
RefSeqiWP_005814129.1. NC_007907.1.

3D structure databases

ProteinModelPortaliQ24YU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi138119.DSY1012.

Protein family/group databases

PeroxiBasei3653. DhaCP01_Y51.

Proteomic databases

PRIDEiQ24YU1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE82801; BAE82801; DSY1012.
KEGGidsy:DSY1012.
PATRICi21670328. VBIDesHaf65307_1131.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_DESHY
AccessioniPrimary (citable) accession number: Q24YU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 18, 2006
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.