ID   THIM_DESHY              Reviewed;         267 AA.
AC   Q24XQ1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Hydroxyethylthiazole kinase;
DE            EC=2.7.1.50;
DE   AltName: Full=4-methyl-5-beta-hydroxyethylthiazole kinase;
DE            Short=Thz kinase;
DE            Short=TH kinase;
GN   Name=thiM; OrderedLocusNames=DSY1402;
OS   Desulfitobacterium hafniense (strain Y51).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC   Desulfitobacterium.
OX   NCBI_TaxID=138119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16513756; DOI=10.1128/JB.188.6.2262-2274.2006;
RA   Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K.,
RA   Inatomi K., Furukawa K., Inui M., Yukawa H.;
RT   "Complete genome sequence of the dehalorespiring bacterium
RT   Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides
RT   ethenogenes 195.";
RL   J. Bacteriol. 188:2262-2274(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + 4-methyl-5-(2-hydroxyethyl)thiazole =
CC       ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine pyrophosphate
CC       biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 4-methyl-
CC       5-(2-hydroxyethyl)-thiazole: step 1/1.
CC   -!- SIMILARITY: Belongs to the Thz kinase family.
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DR   EMBL; AP008230; BAE83191.1; -; Genomic_DNA.
DR   RefSeq; YP_517635.1; -.
DR   GeneID; 3954052; -.
DR   GenomeReviews; AP008230_GR; DSY1402.
DR   KEGG; dsy:DSY1402; -.
DR   NMPDR; fig|138119.3.peg.1674; -.
DR   HOGENOM; Q24XQ1; -.
DR   OMA; Q24XQ1; MANEAPE.
DR   BioCyc; DHAF138119:DSY1402-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004417; F:hydroxyethylthiazole kinase activity; IEA:HAMAP.
DR   GO; GO:0009228; P:thiamin biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00228; -; 1.
DR   InterPro; IPR000417; Hyethyz_kinase.
DR   InterPro; IPR011144; Hyethyz_kinsmonf.
DR   PANTHER; PTHR20857:SF14; Hyethyz_kinase; 1.
DR   Pfam; PF02110; HK; 1.
DR   PIRSF; PIRSF000513; Thz_kinase; 1.
DR   PRINTS; PR01099; HYETHTZKNASE.
DR   TIGRFAMs; TIGR00694; thiM; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Thiamine biosynthesis; Transferase.
FT   CHAIN         1    267       Hydroxyethylthiazole kinase.
FT                                /FTId=PRO_0000336553.
FT   BINDING      44     44       Substrate; via amide nitrogen (By
FT                                similarity).
FT   BINDING     120    120       ATP (By similarity).
FT   BINDING     166    166       ATP (By similarity).
FT   BINDING     193    193       Substrate; via amide nitrogen (By
FT                                similarity).
SQ   SEQUENCE   267 AA;  27836 MW;  049C1D24411E604E CRC64;
     MKEKLTEALQ ALKQKTPLVH AITNVVTVND CANSLLAVGA SPAMCEAADE VFEFSQLAGS
     LYLNLGTLTK EQEMAAYLAI RGATLKGIPV ILDPVACGAI PRKKATIERL GHFGRFTVIK
     GNLGEVKALA GLAARVRGVD SLDEGNDGLE ACQSLARAYG CVVAATGKVD IVADGQRACL
     IENGTEMLTR ITGAGCMAGA LVAGFCGAYE DAFGATVAAL LTMSLAGELA QETSGGELPG
     TFRAHLIDQL SLVDEALIEK RGRVQWL
//