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Q24XQ1

- THIM_DESHY

UniProt

Q24XQ1 - THIM_DESHY

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Substrate; via amide nitrogenUniRule annotation
Binding sitei120 – 1201ATPUniRule annotation
Binding sitei166 – 1661ATPUniRule annotation
Binding sitei193 – 1931Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDHAF138119:GHT5-1431-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:DSY1402
OrganismiDesulfitobacterium hafniense (strain Y51)
Taxonomic identifieri138119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000001946: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Hydroxyethylthiazole kinasePRO_0000336553Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi138119.DSY1402.

Structurei

3D structure databases

ProteinModelPortaliQ24XQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiTISESTY.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q24XQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEKLTEALQ ALKQKTPLVH AITNVVTVND CANSLLAVGA SPAMCEAADE
60 70 80 90 100
VFEFSQLAGS LYLNLGTLTK EQEMAAYLAI RGATLKGIPV ILDPVACGAI
110 120 130 140 150
PRKKATIERL GHFGRFTVIK GNLGEVKALA GLAARVRGVD SLDEGNDGLE
160 170 180 190 200
ACQSLARAYG CVVAATGKVD IVADGQRACL IENGTEMLTR ITGAGCMAGA
210 220 230 240 250
LVAGFCGAYE DAFGATVAAL LTMSLAGELA QETSGGELPG TFRAHLIDQL
260
SLVDEALIEK RGRVQWL
Length:267
Mass (Da):27,836
Last modified:April 18, 2006 - v1
Checksum:i049C1D24411E604E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008230 Genomic DNA. Translation: BAE83191.1.
RefSeqiYP_517635.1. NC_007907.1.

Genome annotation databases

EnsemblBacteriaiBAE83191; BAE83191; DSY1402.
GeneIDi3954052.
KEGGidsy:DSY1402.
PATRICi21671191. VBIDesHaf65307_1560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008230 Genomic DNA. Translation: BAE83191.1 .
RefSeqi YP_517635.1. NC_007907.1.

3D structure databases

ProteinModelPortali Q24XQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 138119.DSY1402.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE83191 ; BAE83191 ; DSY1402 .
GeneIDi 3954052.
KEGGi dsy:DSY1402.
PATRICi 21671191. VBIDesHaf65307_1560.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi TISESTY.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci DHAF138119:GHT5-1431-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
    Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
    J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y51.

Entry informationi

Entry nameiTHIM_DESHY
AccessioniPrimary (citable) accession number: Q24XQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 18, 2006
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3