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Q24VD4

- GSA_DESHY

UniProt

Q24VD4 - GSA_DESHY

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDHAF138119:GHT5-2279-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:DSY2219
    OrganismiDesulfitobacterium hafniense (strain Y51)
    Taxonomic identifieri138119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
    ProteomesiUP000001946: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382307Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi138119.DSY2219.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24VD4.
    SMRiQ24VD4. Positions 4-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q24VD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFQDQRSKE AFARANGVLP GGVNSPVRAF KSVGREPIFI AKGQGARLWD    50
    IDGNSYLDYV LSWGPLILGH AHPVVVGAIK AAAERGTSYG APTEIETECA 100
    EEVIKAFPSM EMVRMVSSGT EATMSALRLA RGVTGRNKII KFEGCYHGHG 150
    DSLLIKAGSG ALTFGVPTSP GVPSSVASQT IVAQYNDLEG LKEIFKECGE 200
    DIAAVILEPV TGNMGVVLPQ PGFLAGLRTL TQDYGSLLIF DEVMTGFRVS 250
    YGGAQGRYQI DPDLTCLGKV IGGGLPVAAY GGKRKYMEQV APSGPIYQAG 300
    TLSGNPLAMA AGLATLKLLQ QEGVYEGLEK KTTRLAEGLQ SIAQELGFPI 350
    WVNSVGAMFS AFFTDQPVID FKSACSSDVE RFGSFFRGML ERGIYLAPSQ 400
    YEAVFLSAAH TDADIDYTLE QARDVLKSLG 430
    Length:430
    Mass (Da):45,778
    Last modified:April 18, 2006 - v1
    Checksum:iF0DDEBB557B34E8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE84008.1.
    RefSeqiYP_518452.1. NC_007907.1.

    Genome annotation databases

    EnsemblBacteriaiBAE84008; BAE84008; DSY2219.
    GeneIDi3955024.
    KEGGidsy:DSY2219.
    PATRICi21673126. VBIDesHaf65307_2502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE84008.1 .
    RefSeqi YP_518452.1. NC_007907.1.

    3D structure databases

    ProteinModelPortali Q24VD4.
    SMRi Q24VD4. Positions 4-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 138119.DSY2219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE84008 ; BAE84008 ; DSY2219 .
    GeneIDi 3955024.
    KEGGi dsy:DSY2219.
    PATRICi 21673126. VBIDesHaf65307_2502.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci DHAF138119:GHT5-2279-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
      Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
      J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y51.

    Entry informationi

    Entry nameiGSA_DESHY
    AccessioniPrimary (citable) accession number: Q24VD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3