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Q24U09

- DEF_DESHY

UniProt

Q24U09 - DEF_DESHY

Protein

Peptide deformylase

Gene

def

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881IronUniRule annotation
    Metal bindingi130 – 1301IronUniRule annotation
    Active sitei131 – 1311UniRule annotation
    Metal bindingi134 – 1341IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciDHAF138119:GHT5-2758-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:DSY2694
    OrganismiDesulfitobacterium hafniense (strain Y51)
    Taxonomic identifieri138119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
    ProteomesiUP000001946: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150Peptide deformylasePRO_0000301025Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi138119.DSY2694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24U09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OMAiELLAICI.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q24U09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIYQIVEIG SEVLREKAVP VKEITPNIEK LLDNMLDTLY DANGVGLAAP    50
    QVGVSKRVVV IDVGEGPIEL INPVIIAKEG EDLDDEGCLS IPGITGQVAR 100
    AAKVKVEALN RQGELQVIEG EGLLARCLQH EIDHLEGILF VDKAKKTQRR 150
    Length:150
    Mass (Da):16,272
    Last modified:April 18, 2006 - v1
    Checksum:i39F668C27CEA6BB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE84483.1.
    RefSeqiWP_011460527.1. NC_007907.1.
    YP_518927.1. NC_007907.1.

    Genome annotation databases

    EnsemblBacteriaiBAE84483; BAE84483; DSY2694.
    GeneIDi3953355.
    KEGGidsy:DSY2694.
    PATRICi21674160. VBIDesHaf65307_3015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE84483.1 .
    RefSeqi WP_011460527.1. NC_007907.1.
    YP_518927.1. NC_007907.1.

    3D structure databases

    ProteinModelPortali Q24U09.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 138119.DSY2694.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE84483 ; BAE84483 ; DSY2694 .
    GeneIDi 3953355.
    KEGGi dsy:DSY2694.
    PATRICi 21674160. VBIDesHaf65307_3015.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OMAi ELLAICI.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci DHAF138119:GHT5-2758-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
      Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
      J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y51.

    Entry informationi

    Entry nameiDEF_DESHY
    AccessioniPrimary (citable) accession number: Q24U09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3