Reviewed, UniProtKB/Swiss-Prot Q24TH5 (GCSPA_DESHY)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	DSY2878

Organism

Desulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]

Taxonomic identifier

138119 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfitobacterium

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045644

Sequences

	Sequence		Length	Mass (Da)
	Q24TH5-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: F98052E4B868FF36	FASTA	446	49,341
	10 20 30 40 50 60 MNYVPNTVDQ QEQILTRIGV GSLEELFADI PESVRRQAQL KIREGLSELE LVKYMGRLAA 70 80 90 100 110 120 ENKTVEEYTS YLGAGAYEHF IPSYVDQLLL RSEFYTAYTP YQPEISQGTL QAIYEFQTLV 130 140 150 160 170 180 CELTGMDGAN ASMYDGASAL AEAALMSCDA TRRKKVLVPQ TIHPEYREVL RTYLLPRGVE 190 200 210 220 230 240 ILEIPYQEGA VDSEALEKAL NTEVAAVLIQ SPNFFGMIEK AEEIGQMAHA KGGLLVMAVN 250 260 270 280 290 300 PVSLGLLKSP GELGADIVVG EGQPFGNPLN FGGPYLGFLA CREKYVRRMP GRIVGATKDK 310 320 330 340 350 360 NGKKGYVLTL QAREQHIRRE KAASNICSNE ALCALAFTIH LSGLGKRGLK EMARLNLQKA 370 380 390 400 410 420 HYGAEEIGKL PGMSLAFQGP FFHEFVIKTE VSPRKINEAL LSHKIIGGLE LSRFYPELDQ 430 440 HLLFCVTETK TKEDIDRLVA GMGEIK

References

[1]

"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195." Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H. J. Bacteriol. 188:2262-2274(2006) [PubMed: 16513756] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008230 Genomic DNA. Translation: BAE84667.1.
RefSeq	YP_519111.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3955264.
GenomeReviews	Gene locus DSY2878 in contig AP008230_GR.
KEGG	dsy:DSY2878.
NMPDR	fig|138119.3.peg.3412.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q24TH5.
OMA	Q24TH5. VANASMY.
Enzyme and pathway databases
BioCyc	DHAF138119:DSY2878-MON.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_DESHY

Accession

Primary (citable) accession number: Q24TH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 18, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)