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Q24TH5 (GCSPA_DESHY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:DSY2878
OrganismDesulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]
Taxonomic identifier138119 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045644

Sequences

Sequence LengthMass (Da)Tools
Q24TH5 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: F98052E4B868FF36

FASTA44649,341
        10         20         30         40         50         60 
MNYVPNTVDQ QEQILTRIGV GSLEELFADI PESVRRQAQL KIREGLSELE LVKYMGRLAA 

        70         80         90        100        110        120 
ENKTVEEYTS YLGAGAYEHF IPSYVDQLLL RSEFYTAYTP YQPEISQGTL QAIYEFQTLV 

       130        140        150        160        170        180 
CELTGMDGAN ASMYDGASAL AEAALMSCDA TRRKKVLVPQ TIHPEYREVL RTYLLPRGVE 

       190        200        210        220        230        240 
ILEIPYQEGA VDSEALEKAL NTEVAAVLIQ SPNFFGMIEK AEEIGQMAHA KGGLLVMAVN 

       250        260        270        280        290        300 
PVSLGLLKSP GELGADIVVG EGQPFGNPLN FGGPYLGFLA CREKYVRRMP GRIVGATKDK 

       310        320        330        340        350        360 
NGKKGYVLTL QAREQHIRRE KAASNICSNE ALCALAFTIH LSGLGKRGLK EMARLNLQKA 

       370        380        390        400        410        420 
HYGAEEIGKL PGMSLAFQGP FFHEFVIKTE VSPRKINEAL LSHKIIGGLE LSRFYPELDQ 

       430        440 
HLLFCVTETK TKEDIDRLVA GMGEIK 

« Hide

References

[1]"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y51.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008230 Genomic DNA. Translation: BAE84667.1.
RefSeqYP_519111.1. NC_007907.1.

3D structure databases

ProteinModelPortalQ24TH5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING138119.DSY2878.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE84667; BAE84667; DSY2878.
GeneID3955264.
KEGGdsy:DSY2878.
PATRIC21674586. VBIDesHaf65307_3228.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycDHAF138119:GHT5-2942-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_DESHY
AccessionPrimary (citable) accession number: Q24TH5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families