Q24TH3 (GCST_DESHY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	DSY2880

Organism

Desulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]

Taxonomic identifier

138119 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfitobacterium

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Aminomethyltransferase HAMAP MF_00259		PRO_1000059083

Sequences

	Sequence		Length	Mass (Da)
	Q24TH3 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 039615DE8C8A1A93	FASTA	365	40,814
	10 20 30 40 50 60 MTELKRTPLY EQHRRAGAKL IDFGGWEMPV QYAGVIEEHK AVRSKAGLFD VSHMGEVELK 70 80 90 100 110 120 GKDSLAFLQY LLTNDVSRIQ DNQIQYSPMC TSAGGVVDDL LVYRYSREHF LLVVNAANTD 130 140 150 160 170 180 KDFAWMQAQA EGFEISLENR SGDFAQLALQ GPWAEKILQK LTSMDLAQIN YYWFKHGEVD 190 200 210 220 230 240 GVLCLISRTG YTGEDGFEIY LPPEHAPRMW ERILEVGGSE GVQPIGLGAR DTLRFEARLP 250 260 270 280 290 300 LYGNELGPDI TPLEAGLGFF VKLEKDNFIG KEALSAQKEK GVPRKLVGLE MIERGIARSH 310 320 330 340 350 360 YPLQKEGKEI GFITSGSFSP TLNKNIALGL IPPEYAQIGE TLDVIIRGKA VKARIIPSLF YKRQG

References

[1]

"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195." Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H. J. Bacteriol. 188:2262-2274(2006) [PubMed: 16513756] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Y51.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008230 Genomic DNA. Translation: BAE84669.1.
RefSeq	YP_519113.1. NC_007907.1.
3D structure databases
ProteinModelPortal	Q24TH3.
SMR	Q24TH3. Positions 4-360.
ModBase	Search...
Protein-protein interaction databases
STRING	Q24TH3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3955266.
GenomeReviews	Gene locus DSY2880 in contig AP008230_GR.
KEGG	dsy:DSY2880.
NMPDR	fig|138119.3.peg.3414.
PATRIC	21674590. VBIDesHaf65307_3230.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	GWEMPIS.
PhylomeDB	Q24TH3.
ProtClustDB	CLSK2466451.
Enzyme and pathway databases
BioCyc	DHAF138119:DSY2880-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_DESHY

Accession

Primary (citable) accession number: Q24TH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program