Q24SU9 (DEOC_DESHY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	DSY3104

Organism

Desulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]

Taxonomic identifier

138119 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfitobacterium

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000015315
Sites
	Active site	156	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	185	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q24SU9 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 0BD618A41C47AA00	FASTA	218	23,020
	10 20 30 40 50 60 MRTMNLAGMI DHTFLKPEAT EKDIVNLCHE AKQHKFATVC INPAYICTAA KLLHGSGVGV 70 80 90 100 110 120 ATVIGFPLGA TMTEIKVQEI FAAKAHGARE VDIVINIGWA KSGNWEAVAK DITRAVEAAH 130 140 150 160 170 180 CCGVTIKVII ETSLLTEEEK QKAAEIVKAS GADYIKTSTG FAGGGATVED VRNLKAWVGQ 190 200 210 SVKVKASGGI RSRETALQMV EAGADRLGTS SGVQIITV

References

[1]

"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195." Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H. J. Bacteriol. 188:2262-2274(2006) [PubMed: 16513756] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Y51.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP008230 Genomic DNA. Translation: BAE84893.1.
RefSeq	YP_519337.1. NC_007907.1.
3D structure databases
ProteinModelPortal	Q24SU9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q24SU9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3955575.
GenomeReviews	Gene locus DSY3104 in contig AP008230_GR.
KEGG	dsy:DSY3104.
NMPDR	fig|138119.3.peg.4658.
PATRIC	21675088. VBIDesHaf65307_3476.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0274.
HOGENOM	HBG636421.
OMA	IDHTNLK.
PhylomeDB	Q24SU9.
ProtClustDB	CLSK2466565.
Enzyme and pathway databases
BioCyc	DHAF138119:DSY3104-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_DESHY

Accession

Primary (citable) accession number: Q24SU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program