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Q24SP5

- SYL_DESHY

UniProt

Q24SP5 - SYL_DESHY

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Protein
Leucine--tRNA ligase
Gene
leuS, DSY3158
Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei586 – 5861ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDHAF138119:GHT5-3226-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:DSY3158
OrganismiDesulfitobacterium hafniense (strain Y51)
Taxonomic identifieri138119 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
ProteomesiUP000001946: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827Leucine--tRNA ligaseUniRule annotation
PRO_0000334749Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi138119.DSY3158.

Structurei

3D structure databases

ProteinModelPortaliQ24SP5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi583 – 5875"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24SP5-1 [UniParc]FASTAAdd to Basket

« Hide

MQEKYLFSEI EPKWQKKWVD RKDYQAEEHS DKPKFYALAM FPYPSGNLHM    50
GHVRNYSIVD VIARFKRMRG YNVLHPIGWD SFGLPAENAA IKNQTPPAEW 100
TWKNIANMKR QLQEMGISYD WEREVTTCHP DYYKFTQWIF LEFYKHGLVY 150
KKKAGVNWCP SCATVLANEQ VVDGACERCD TAVTKKDLEQ WFFKITDYAQ 200
VLLDDLEKLP GWPDKVKTMQ KNWIGRSEGA EVEFDLENHG DKIRVYTTRV 250
DTIFGVSYVV LAPEHPLVQK LIAGTEYEND VQAFIERMKG LNEIARTSTE 300
TEKEGLFTGA YCINPYSGEK VPIWIANYVL FEYGTGAVMG VPAHDERDFE 350
FAGKYKLPIK TVILPEGTPV EEKDTPLQAA FVEEGMMVNS GEYDGLKNVE 400
AWEKMCDKAE HDGFGERKVN FRLRDWLISR QRYWGAPIPM IYCDHCGIVP 450
VPQDQLPVML PDDVVFKAGE NPLTTSESFK QTICPTCGGK ARRETDTMDT 500
FMCSSWYFLR YTDPHNAQLP FAKEAADHWM NVDQYVGGVE HAILHLLYSR 550
FFTKALRDFG YLKVDEPFAN LLTQGMVCLG GAKMSKSKGN VVSPEEIISK 600
YGADTARLFI LFAAPPERDL EWNDQGVEGC YRFLNRVWRL AAQYEEVLKT 650
TGAGANEFGE LDKAAKDMRR QTHQTIQRVT SDVGARFNFN TAVSAIMELV 700
NALYLYKEQP QVNLAVAREA LESILILLAP FAPHITEEIW SELGHEDSIH 750
SREWPQVDEE ALVQEEVTVV LQINGKVKER IQVPAQISAA ELEAQVRQLP 800
RLGEWTQGKQ ILKIVTVPGK LVNVVVK 827
Length:827
Mass (Da):94,532
Last modified:April 18, 2006 - v1
Checksum:i9ABC3B33C891064E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008230 Genomic DNA. Translation: BAE84947.1.
RefSeqiYP_519391.1. NC_007907.1.

Genome annotation databases

EnsemblBacteriaiBAE84947; BAE84947; DSY3158.
GeneIDi3956540.
KEGGidsy:DSY3158.
PATRICi21675200. VBIDesHaf65307_3532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008230 Genomic DNA. Translation: BAE84947.1 .
RefSeqi YP_519391.1. NC_007907.1.

3D structure databases

ProteinModelPortali Q24SP5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 138119.DSY3158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAE84947 ; BAE84947 ; DSY3158 .
GeneIDi 3956540.
KEGGi dsy:DSY3158.
PATRICi 21675200. VBIDesHaf65307_3532.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DHAF138119:GHT5-3226-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
    Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
    J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y51.

Entry informationi

Entry nameiSYL_DESHY
AccessioniPrimary (citable) accession number: Q24SP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi