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Q24SP5

- SYL_DESHY

UniProt

Q24SP5 - SYL_DESHY

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfitobacterium hafniense (strain Y51)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei586 – 5861ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDHAF138119:GHT5-3226-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:DSY3158
    OrganismiDesulfitobacterium hafniense (strain Y51)
    Taxonomic identifieri138119 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium
    ProteomesiUP000001946: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 827827Leucine--tRNA ligasePRO_0000334749Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi138119.DSY3158.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24SP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi583 – 5875"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q24SP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEKYLFSEI EPKWQKKWVD RKDYQAEEHS DKPKFYALAM FPYPSGNLHM    50
    GHVRNYSIVD VIARFKRMRG YNVLHPIGWD SFGLPAENAA IKNQTPPAEW 100
    TWKNIANMKR QLQEMGISYD WEREVTTCHP DYYKFTQWIF LEFYKHGLVY 150
    KKKAGVNWCP SCATVLANEQ VVDGACERCD TAVTKKDLEQ WFFKITDYAQ 200
    VLLDDLEKLP GWPDKVKTMQ KNWIGRSEGA EVEFDLENHG DKIRVYTTRV 250
    DTIFGVSYVV LAPEHPLVQK LIAGTEYEND VQAFIERMKG LNEIARTSTE 300
    TEKEGLFTGA YCINPYSGEK VPIWIANYVL FEYGTGAVMG VPAHDERDFE 350
    FAGKYKLPIK TVILPEGTPV EEKDTPLQAA FVEEGMMVNS GEYDGLKNVE 400
    AWEKMCDKAE HDGFGERKVN FRLRDWLISR QRYWGAPIPM IYCDHCGIVP 450
    VPQDQLPVML PDDVVFKAGE NPLTTSESFK QTICPTCGGK ARRETDTMDT 500
    FMCSSWYFLR YTDPHNAQLP FAKEAADHWM NVDQYVGGVE HAILHLLYSR 550
    FFTKALRDFG YLKVDEPFAN LLTQGMVCLG GAKMSKSKGN VVSPEEIISK 600
    YGADTARLFI LFAAPPERDL EWNDQGVEGC YRFLNRVWRL AAQYEEVLKT 650
    TGAGANEFGE LDKAAKDMRR QTHQTIQRVT SDVGARFNFN TAVSAIMELV 700
    NALYLYKEQP QVNLAVAREA LESILILLAP FAPHITEEIW SELGHEDSIH 750
    SREWPQVDEE ALVQEEVTVV LQINGKVKER IQVPAQISAA ELEAQVRQLP 800
    RLGEWTQGKQ ILKIVTVPGK LVNVVVK 827
    Length:827
    Mass (Da):94,532
    Last modified:April 18, 2006 - v1
    Checksum:i9ABC3B33C891064E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE84947.1.
    RefSeqiYP_519391.1. NC_007907.1.

    Genome annotation databases

    EnsemblBacteriaiBAE84947; BAE84947; DSY3158.
    GeneIDi3956540.
    KEGGidsy:DSY3158.
    PATRICi21675200. VBIDesHaf65307_3532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008230 Genomic DNA. Translation: BAE84947.1 .
    RefSeqi YP_519391.1. NC_007907.1.

    3D structure databases

    ProteinModelPortali Q24SP5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 138119.DSY3158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE84947 ; BAE84947 ; DSY3158 .
    GeneIDi 3956540.
    KEGGi dsy:DSY3158.
    PATRICi 21675200. VBIDesHaf65307_3532.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DHAF138119:GHT5-3226-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
      Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
      J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Y51.

    Entry informationi

    Entry nameiSYL_DESHY
    AccessioniPrimary (citable) accession number: Q24SP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3