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Q24QH6 (PUR9_DESHY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:DSY3927
OrganismDesulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]
Taxonomic identifier138119 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018885

Sequences

Sequence LengthMass (Da)Tools
Q24QH6 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: E7DA270C19594570

FASTA51856,114
        10         20         30         40         50         60 
MNRRAVLSVS NKTGLVELAR GLVELGFDLI STGGTFKTLT EAGLPVRYVT EVTGFPEILD 

        70         80         90        100        110        120 
GRVKTLHPRI HGGILARATA EHLQQLEDNG IGLIDLVVVN LYPFKETIAR PGVSFQEAIE 

       130        140        150        160        170        180 
NIDIGGPSMV RAAAKNQERV SIVVNPERYP EVLQALREQG EISYDMRKRL AAEAFAHTAE 

       190        200        210        220        230        240 
YDQCIAGYLT AALAEESVSS SSSPFPATIT LGGQKAQDLR YGENPAQKAA FYRGADAAGT 

       250        260        270        280        290        300 
LAYGEQIQGK ELSYNNWMDM DAAWGIVQDF SEPACAIIKH TNPCGTALGK TALEAYEKAL 

       310        320        330        340        350        360 
AADPVSAFGG IIAFNRTVDA ECAASLKAHF YEVIVAHEFS SDARAILQEK KNLRLVKVAQ 

       370        380        390        400        410        420 
DGKPAHTPWK VRSIQGGFLI QEEDEGTTPI SAWEVVSKRQ PEPEELRELD FAWRVVKHVK 

       430        440        450        460        470        480 
SNAIVLAKAG QTLGVGAGQM NRVGSVKIAL EQAGDKAQGA YLASDAFFPF PDSLEEAAKA 

       490        500        510 
GVRAVVQPGG SVRDAEVIEA ADRLNLIMVF TNRRHFKH 

« Hide

References

[1]"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y51.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008230 Genomic DNA. Translation: BAE85716.1.
RefSeqYP_520160.1. NC_007907.1.

3D structure databases

ProteinModelPortalQ24QH6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING138119.DSY3927.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE85716; BAE85716; DSY3927.
GeneID3955908.
KEGGdsy:DSY3927.
PATRIC21676922. VBIDesHaf65307_4391.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230372.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBCLSK2466851.

Enzyme and pathway databases

BioCycDHAF138119:GHT5-3999-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_DESHY
AccessionPrimary (citable) accession number: Q24QH6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways