Reviewed, UniProtKB/Swiss-Prot Q24QH4 (PUR5_DESHY)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	DSY3929

Organism

Desulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]

Taxonomic identifier

138119 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfitobacterium

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/5. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_0000258350

Sequences

	Sequence		Length	Mass (Da)
	Q24QH4-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: C8C584C7B542E497	FASTA	339	36,329
	10 20 30 40 50 60 MGYSYRQAGV DIDAGNQAVE LMKPAVKRTV RPEVMGGLGG FGGLFALDLK KYPEPVLVSG 70 80 90 100 110 120 TDGVGTKLKL AFQMNRHDTI GQDAVAMCVN DILVQGAEPL FFLDYLAVGK LVPERVAQVV 130 140 150 160 170 180 GGIAKGCELA GCALIGGETA EMPGFYDEGE YDIAGFAVGA VNRPDLIDGS QIQAGDVLIG 190 200 210 220 230 240 LPSSGFHSNG YSLVRKIFTP DLWEKNYPEL GETLGEALIR PTRIYVKTVL PLIESRKVLG 250 260 270 280 290 300 MAHITGGGLT ENIPRILPEG LGIKIARSAW QVPALFTLLQ RLGEVEEAEM LRTFNMGIGF 310 320 330 VLIVHPEDVD FIQTQLQAAG EKCFVLGEVS GQSEGVSYL

References

[1]

"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195." Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H. J. Bacteriol. 188:2262-2274(2006) [PubMed: 16513756] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP008230 Genomic DNA. Translation: BAE85718.1.
RefSeq	YP_520162.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3956418.
GenomeReviews	Gene locus DSY3929 in contig AP008230_GR.
KEGG	dsy:DSY3929.
NMPDR	fig|138119.3.peg.2927.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q24QH4.
OMA	Q24QH4. VHGLAHI.
Enzyme and pathway databases
BioCyc	DHAF138119:DSY3929-MON.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_DESHY

Accession

Primary (citable) accession number: Q24QH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	April 18, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)