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Q24PT9 (ALLB_DESHY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Allantoinase

EC=3.5.2.5
Alternative name(s):
Allantoin-utilizing enzyme
Gene names
Name:allB
Ordered Locus Names:DSY4164
OrganismDesulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]
Taxonomic identifier138119 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring By similarity. HAMAP-Rule MF_01645

Catalytic activity

(S)-allantoin + H2O = allantoate. HAMAP-Rule MF_01645

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP-Rule MF_01645

Pathway

Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. HAMAP-Rule MF_01645

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01645

Post-translational modification

Carbamylation allows a single lysine to coordinate two zinc ions By similarity. HAMAP-Rule MF_01645

Sequence similarities

Belongs to the DHOase family. Allantoinase subfamily.

Ontologies

Keywords
   Biological processPurine metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processallantoin catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

purine nucleobase metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionallantoinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cobalt ion binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Allantoinase HAMAP-Rule MF_01645
PRO_0000317673

Sites

Metal binding611Zinc 1 By similarity
Metal binding631Zinc 1 By similarity
Metal binding1481Zinc 1; via carbamate group By similarity
Metal binding1481Zinc 2; via carbamate group By similarity
Metal binding1841Zinc 2 By similarity
Metal binding2401Zinc 2 By similarity
Metal binding3131Zinc 1 By similarity

Amino acid modifications

Modified residue1481N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q24PT9 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: E96C55461047E725

FASTA44949,228
        10         20         30         40         50         60 
MSHYDLILRN GNVVCPDGVR KADIAVSDGK IVLIAEEIPG DAKEVIDAAG KHVFPGITDG 

        70         80         90        100        110        120 
HVHFNDPGRT EWETISTGSS ALAAGGGVAY FDMPLNCSPC TLDAVNFNNK LAVAQKDSLV 

       130        140        150        160        170        180 
DYGFWGGLTS ANLDKLDELA ECGVIGFKAF ACHSGIDEFP RMDDYTALVG MEKLAKLGLP 

       190        200        210        220        230        240 
LMVHCENAEI TKELTELSLA NNRTGVRDYF AARPPITEIE NVSRMITFAE ETGCKLIIAH 

       250        260        270        280        290        300 
ISTAKAVDLV AQARARGVDV YCETIGHYLY LTGDDVERLG TVAKCSPPIR DGENQLQMWG 

       310        320        330        340        350        360 
RLFNDNIAFV SSDHSPCDPK LKNGEFMRVW GGISACQTTL QGLLTHAYHD RKFPLVKIAQ 

       370        380        390        400        410        420 
LTAQHVNEIF KIKGKGQINL GYDADFALVD LNHEFTLQAE DLFYKHKVSP YVGDRFRGSV 

       430        440 
SQTILRGTTI YKDGKIVSQP IGKHLRPHQ 

« Hide

References

[1]"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y51.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008230 Genomic DNA. Translation: BAE85953.1.
RefSeqYP_520397.1. NC_007907.1.

3D structure databases

ProteinModelPortalQ24PT9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING138119.DSY4164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE85953; BAE85953; DSY4164.
GeneID3954326.
KEGGdsy:DSY4164.
PATRIC21677434. VBIDesHaf65307_4648.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0044.
HOGENOMHOG000219146.
KOK01466.
OMARWMSTAP.
OrthoDBEOG6KHFW6.

Enzyme and pathway databases

BioCycDHAF138119:GHT5-4236-MONOMER.
UniPathwayUPA00395; UER00653.

Family and domain databases

Gene3D2.30.40.10. 1 hit.
HAMAPMF_01645. Hydantoinase.
InterProIPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMSSF51338. SSF51338. 2 hits.
TIGRFAMsTIGR03178. allantoinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALLB_DESHY
AccessionPrimary (citable) accession number: Q24PT9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways