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Q24MK7 (SYR_DESHY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:DSY4946
OrganismDesulfitobacterium hafniense (strain Y51) [Complete proteome] [HAMAP]
Taxonomic identifier138119 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfitobacterium

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018020

Regions

Motif135 – 14511"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q24MK7 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: AD9B2FED83BC2871

FASTA56163,140
        10         20         30         40         50         60 
MSLYINIKDT IYANLAKAAL EAQKAGELSF ESLPNYVLEE PREKQHGDWA TNLAMVLTKQ 

        70         80         90        100        110        120 
ARKAPRDIAT ILIKHLDTEG TFITASEIAG PGFINFRLDP NWLTGVIPEV LNLEADYGKV 

       130        140        150        160        170        180 
NLGQGKKVQV EFVSANPTGL LHMGNARGAA LGDSLAALLA MAGYEVSREF YINDAGNQIY 

       190        200        210        220        230        240 
NFALSLEARY LQLMGQDVPF PEGGYHGEDL IDTVKGLIEK VGNKYLNVDQ DLRREFLVRY 

       250        260        270        280        290        300 
ALEEKLTSIR ETLTDMGVHY DCWFSEQSLH DSGFVKDTME KLEQQGYIYE KEGAQWLKST 

       310        320        330        340        350        360 
LFGDEKDEVV VRGNGTPTYF AADIAYHRNK FERGFDRVIN IWGADHHGHV ARMKGAMSAL 

       370        380        390        400        410        420 
GYDPENLQII LMQLVRLIQN GEVVRMSKRS GQYITLRELM DEVGKDAARF FFIMRDPDST 

       430        440        450        460        470        480 
VEFDLDLAKA ESSDNPVYYV QYAHARLCSI LRQAAEQGYN TAGIPQEGEL KRLQSNEERE 

       490        500        510        520        530        540 
LLKKIAELPN EIEVAARLTE PHRLARYVLD LAGLFHSFYN SQRVLVDEEG LREARLGLVR 

       550        560 
STKQVLANVL GILGVTAPER M 

« Hide

References

[1]"Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195."
Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K., Inatomi K., Furukawa K., Inui M., Yukawa H.
J. Bacteriol. 188:2262-2274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y51.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008230 Genomic DNA. Translation: BAE86735.1.
RefSeqYP_521179.1. NC_007907.1.

3D structure databases

ProteinModelPortalQ24MK7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING138119.DSY4946.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE86735; BAE86735; DSY4946.
GeneID3957885.
KEGGdsy:DSY4946.
PATRIC21679180. VBIDesHaf65307_5519.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMARFIMLTR.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycDHAF138119:GHT5-5020-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_DESHY
AccessionPrimary (citable) accession number: Q24MK7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries