Q24M88 (Q24M88_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Phosphoinositide-3-kinase gamma polypeptide EMBL AAS75801.1
Organism	Homo sapiens (Human) EMBL AAS75801.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	104 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PI3K/PI4K domain. SAAS SAAS018936

Ontologies

Keywords
Molecular function	Kinase SAAS SAAS018936 EMBL AAS75801.1 Transferase
Gene Ontology (GO)
Biological_process	elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara hepatocyte apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of triglyceride catabolic process Inferred from electronic annotation. Source: Compara phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro positive regulation of acute inflammatory response Inferred from electronic annotation. Source: Compara protein phosphorylation Inferred from electronic annotation. Source: Compara secretory granule localization Inferred from electronic annotation. Source: Compara
Cellular_component	phosphatidylinositol 3-kinase complex Inferred from electronic annotation. Source: Compara
Molecular_function	1-phosphatidylinositol-3-kinase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAS75801.1
	Non-terminal residue	104	1	EMBL AAS75801.1

Sequences

	Sequence		Length	Mass (Da)
	Q24M88 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 893A93DCB32F8D24	FASTA	104	11,627
	10 20 30 40 50 60 NSQLPESFRV PYDPGLKAGA LAIEKCKVMA SKKKPLWLEF KCADPTALSN ETIGIIFKHG 70 80 90 100 DDLRQDMLIL QILRIMESIW ETESLDLCLL PYGCISTGDK IGMI

References

[1]	"Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells." Frey R.S., Gao X., Javaid K., Siddiqui S.S., Rahman A., Malik A.B. J. Biol. Chem. 281:16128-16138(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY496423 mRNA. Translation: AAS75801.1.
IPI	IPI00946767.
UniGene	Hs.32942.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q24M88.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	Q24M88.
Bgee	Q24M88.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR015433. PI_Kinase. [Graphical view]
PANTHER	PTHR10048. PTHR10048. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q24M88.

Entry information

Entry name

Q24M88_HUMAN

Accession

Primary (citable) accession number: Q24M88

Entry history

Integrated into UniProtKB/TrEMBL:	April 18, 2006
Last sequence update:	April 18, 2006
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.