Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatocyte growth factor-like protein

Gene

MST1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Serine protease homolog

Protein family/group databases

MEROPSiS01.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor-like protein
Alternative name(s):
Macrophage stimulatory protein
Macrophage-stimulating protein
Short name:
MSP
Cleaved into the following 2 chains:
Gene namesi
Name:MST1
Synonyms:HGFL
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 712694Hepatocyte growth factor-like proteinPRO_0000285888Add
BLAST
Chaini19 – 484466Hepatocyte growth factor-like protein alpha chainBy similarityPRO_0000285889Add
BLAST
Chaini485 – 712228Hepatocyte growth factor-like protein beta chainBy similarityPRO_0000285890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 78By similarity
Disulfide bondi60 ↔ 66By similarity
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi110 ↔ 186By similarity
Disulfide bondi131 ↔ 169By similarity
Disulfide bondi157 ↔ 181By similarity
Disulfide bondi284 ↔ 362By similarity
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi305 ↔ 344By similarity
Disulfide bondi333 ↔ 356By similarity
Disulfide bondi371 ↔ 449By similarity
Disulfide bondi392 ↔ 432By similarity
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi420 ↔ 444By similarity
Disulfide bondi469 ↔ 589Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondi508 ↔ 524By similarity
Disulfide bondi603 ↔ 668By similarity
Disulfide bondi633 ↔ 647By similarity
Disulfide bondi658 ↔ 686By similarity

Post-translational modificationi

Cleaved after Arg-484, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ24K22.
PRIDEiQ24K22.

Interactioni

Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030635.

Structurei

3D structure databases

ProteinModelPortaliQ24K22.
SMRiQ24K22. Positions 485-709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10585PANPROSITE-ProRule annotationAdd
BLAST
Domaini109 – 18678Kringle 1PROSITE-ProRule annotationAdd
BLAST
Domaini190 – 26879Kringle 2PROSITE-ProRule annotationAdd
BLAST
Domaini283 – 36280Kringle 3PROSITE-ProRule annotationAdd
BLAST
Domaini370 – 44980Kringle 4PROSITE-ProRule annotationAdd
BLAST
Domaini485 – 710226Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation
Contains 4 kringle domains.PROSITE-ProRule annotation
Contains 1 PAN domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
HOVERGENiHBG004381.
InParanoidiQ24K22.

Family and domain databases

InterProiIPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 3 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24K22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLPLLLLL IWFSGAPGQR SPLNDFQVLR GTELQHLLHS VGPGPWQEDV
60 70 80 90 100
ANAEECAGLC GPLLDCRAFH YNLSSHGCQL LPWTQHSPHT RLQRSGRCDL
110 120 130 140 150
FQKKNYVRTC IVDNGVEYRG TVAITVGGLP CQRWSHRFPN DHKFTPTLRN
160 170 180 190 200
GLEENFCRNP DRDPGGPWCY TTDPAVRFQS CGIKSCREAT CLWCNGEDYR
210 220 230 240 250
GSVDSTESGR ECQRWDLQHP HPHPFEPGFW TKIWTTTIAG IRTARSGPGA
260 270 280 290 300
IPPTRRWRES SATYPAAVQR SEAQPSQEAT TLNCFRGKGE GYRGTVNTTA
310 320 330 340 350
AGVPCQRWDA QLPHQHRFAP EKYACKDLRE NFCRNPDGSE APWCFTSRPG
360 370 380 390 400
MRMAFCYQIR RCTDDVRPED CYHGAGELYR GSVSKTRKGI RCQNWSAETP
410 420 430 440 450
HKPQFKHTSA PHTPLEENFC RNPDGDSHGP WCYTTDPGTP FDYCALRRCD
460 470 480 490 500
DDQQPSILET AHQVLFDKCG KRVTRVDPLH SKLRVVGGQP GNSPWTVSLR
510 520 530 540 550
NRQGQHFCGG SLVKEQWVLT ARQCFSSCHM SLVGYEVWLG TLFQDPQPGE
560 570 580 590 600
PDLQHIPMAK MVCGPSGSQL VLLKLERPVI LNQRVALICL PPERYVVPPG
610 620 630 640 650
TRCEIAGWGE TKGTGDDTVL NIALLSVISN QECNVKHRGR VRESEMCTAG
660 670 680 690 700
LLAPVGACEG DYGGPLACFT HDCWVLQGII IPNRVCARPR WPAVFMRVSV
710
FVDWIHKVMR LG
Length:712
Mass (Da):79,973
Last modified:April 18, 2006 - v1
Checksum:i3BA3B1F750B36EFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114002 mRNA. Translation: AAI14003.1.
RefSeqiNP_001069145.1. NM_001075677.2.
UniGeneiBt.60953.

Genome annotation databases

GeneIDi514667.
KEGGibta:514667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114002 mRNA. Translation: AAI14003.1.
RefSeqiNP_001069145.1. NM_001075677.2.
UniGeneiBt.60953.

3D structure databases

ProteinModelPortaliQ24K22.
SMRiQ24K22. Positions 485-709.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030635.

Protein family/group databases

MEROPSiS01.975.

Proteomic databases

PaxDbiQ24K22.
PRIDEiQ24K22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514667.
KEGGibta:514667.

Organism-specific databases

CTDi4485.

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
HOVERGENiHBG004381.
InParanoidiQ24K22.

Family and domain databases

InterProiIPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 3 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiHGFL_BOVIN
AccessioniPrimary (citable) accession number: Q24K22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: April 18, 2006
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack catalytic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.