Q24JQ0 (CR045_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein C18orf45

Gene names

Name:

C18orf45

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q24JQ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q24JQ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     146-159: FNPDGYFWAIIHLL → GLIKFYRSPRNPVH
     160-296: Missing.

Isoform 3 (identifier: Q24JQ0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     41-66: Missing.
     128-149: SALLLLAAAGCLPFNDSQFNPD → RLHLERTRQNQTSRLSSCLKGD
     150-296: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Transmembrane protein C18orf45		PRO_0000307316
Regions
	Transmembrane	7 – 29	23	Helical; Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	121 – 141	21	Helical; Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	211 – 231	21	Helical; Potential
	Transmembrane	250 – 270	21	Helical; Potential
	Transmembrane	271 – 291	21	Helical; Potential
Natural variations
	Alternative sequence	41 – 66	26	Missing in isoform 3.		VSP_028704
	Alternative sequence	128 – 149	22	SALLL…QFNPD → RLHLERTRQNQTSRLSSCLK GD in isoform 3.		VSP_028705
	Alternative sequence	146 – 159	14	FNPDG…IIHLL → GLIKFYRSPRNPVH in isoform 2.		VSP_028706
	Alternative sequence	150 – 296	147	Missing in isoform 3.		VSP_028707
	Alternative sequence	160 – 296	137	Missing in isoform 2.		VSP_028708
	Natural variant	131	1	L → F. Ref.1 Corresponds to variant rs8099409 [ dbSNP | Ensembl ].		VAR_035406

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: E84189255BCA2A96	FASTA	296	32,647
	10 20 30 40 50 60 MCVRRSLVGL TFCTCYLASY LTNKYVLSVL KFTYPTLFQG WQTLIGGLLL HVSWKLGWVE 70 80 90 100 110 120 INSSSRSHVL VWLPASVLFV GIIYAGSRAL SRLAIPVFLT LHNVAEVIIC GYQKCFQKEK 130 140 150 160 170 180 TSPAKICSAL LLLAAAGCLP FNDSQFNPDG YFWAIIHLLC VGAYKILQKS QKPSALSDID 190 200 210 220 230 240 QQYLNYIFSV VLLAFASHPT GDLFSVLDFP FLYFYRFHGS CCASGFLGFF LMFSTVKLKN 250 260 270 280 290 LLAPGQCAAW IFFAKIITAG LSILLFDAIL TSATTGCLLL GALGEALLVF SERKSS
	Isoform 2 [UniParc]. Checksum: AE3B9A24FBDDF9E8	FASTA	159	17,699
	10 20 30 40 50 60 MCVRRSLVGL TFCTCYLASY LTNKYVLSVL KFTYPTLFQG WQTLIGGLLL HVSWKLGWVE 70 80 90 100 110 120 INSSSRSHVL VWLPASVLFV GIIYAGSRAL SRLAIPVFLT LHNVAEVIIC GYQKCFQKEK 130 140 150 TSPAKICSAL LLLAAAGCLP FNDSQGLIKF YRSPRNPVH
	Isoform 3 [UniParc]. Checksum: 16F4EAACC00EFF80	FASTA	123	13,865
	10 20 30 40 50 60 MCVRRSLVGL TFCTCYLASY LTNKYVLSVL KFTYPTLFQG SHVLVWLPAS VLFVGIIYAG 70 80 90 100 110 120 SRALSRLAIP VFLTLHNVAE VIICGYQKCF QKEKTSPAKI CRLHLERTRQ NQTSRLSSCL KGD

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT PHE-131. Tissue: Fibroblast and Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK123623 mRNA. Translation: BAC85665.1. AK126247 mRNA. Translation: BAC86502.1. BC114510 mRNA. Translation: AAI14511.1. BC114561 mRNA. Translation: AAI14562.1.
IPI	IPI00446436. IPI00798293. IPI00868802.
RefSeq	NP_116322.3. NM_032933.4.
UniGene	Hs.137562.
3D structure databases
ProteinModelPortal	Q24JQ0.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1450004.
Polymorphism databases
DMDM	121940968.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383233; ENSP00000372720; ENSG00000134490.
GeneID	85019.
KEGG	hsa:85019.
UCSC	uc002kuf.1. human.
Organism-specific databases
CTD	85019.
GeneCards	GC18M020875.
HGNC	HGNC:31723. C18orf45.
neXtProt	NX_Q24JQ0.
PharmGKB	PA134952915.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20889.
HOGENOM	HBG717763.
HOVERGEN	HBG096703.
InParanoid	Q24JQ0.
OMA	CVGAYKI.
OrthoDB	EOG4KWJTG.
PhylomeDB	Q24JQ0.
Gene expression databases
ArrayExpress	Q24JQ0.
Bgee	Q24JQ0.
CleanEx	HS_C18orf45.
Genevestigator	Q24JQ0.
Family and domain databases
ProtoNet	Search...
Other
NextBio	75655.

Entry information

Entry name

CR045_HUMAN

Accession

Primary (citable) accession number: Q24JQ0
Secondary accession number(s): Q6ZTS7, Q6ZW41

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.