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Q24JJ8

- GLO3_ARATH

UniProt

Q24JJ8 - GLO3_ARATH

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Protein
Peroxisomal (S)-2-hydroxy-acid oxidase GLO3
Gene
GLO3, At3g14150, MAG2.11
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMN By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071FMN By similarity
Binding sitei128 – 1281FMN By similarity
Binding sitei130 – 1301Substrate By similarity
Binding sitei156 – 1561FMN By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei228 – 2281FMN By similarity
Active sitei252 – 2521Proton acceptor By similarity
Binding sitei255 – 2551Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi283 – 30725FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
  3. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
  4. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. defense response signaling pathway, resistance gene-independent Source: TAIR
  2. defense response to bacterium Source: TAIR
  3. hydrogen peroxide biosynthetic process Source: TAIR
  4. oxidative photosynthetic carbon pathway Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolate pathway, Photorespiration

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciARA:AT3G14150-MONOMER.
ARA:GQT-2460-MONOMER.
UniPathwayiUPA00951; UER00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal (S)-2-hydroxy-acid oxidase GLO3 (EC:1.1.3.15)
Alternative name(s):
Glycolate oxidase 3
Short name:
AtGLO3
Short name:
GOX 3
Short chain alpha-hydroxy acid oxidase GLO3
Gene namesi
Name:GLO3
Ordered Locus Names:At3g14150
ORF Names:MAG2.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G14150.

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Peroxisomal (S)-2-hydroxy-acid oxidase GLO3
PRO_0000403406Add
BLAST

Proteomic databases

PaxDbiQ24JJ8.
PRIDEiQ24JJ8.

Expressioni

Gene expression databases

GenevestigatoriQ24JJ8.

Interactioni

Subunit structurei

Homotetramer or homooctamer By similarity.

Protein-protein interaction databases

STRINGi3702.AT3G14150.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ24JJ8.
SMRiQ24JJ8. Positions 3-355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 357357FMN hydroxy acid dehydrogenase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi361 – 3633Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217463.
InParanoidiQ24JJ8.
KOiK11517.
OMAiYVQHAEA.
PhylomeDBiQ24JJ8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24JJ8-1 [UniParc]FASTAAdd to Basket

« Hide

MDQIVNVDEF QELAKQALPK MYYDFYNGGA EDQHTLNENV QAFRRIMFRP    50
RVLVDVSKID MSTKILGYPI SAPIMIAPTG NHKLAHPEGE TATAKAAAAC 100
NTIMIVSYMS SCTFEEIASS CNAVRFLQIY VYKRRDITAQ VVKRAEKAGF 150
KAIVLTVDVP RLGRREADIK NKMISPQLKN FEGLFSTEVR PSKGSGVQAF 200
ASRAFDASFS WKDIEWLRSI TELPILVKGI LTREDALKAV EAGVDGIIVS 250
NHGGRQLDYS PATITVLEEV VQVVRGRIPV LLDGGVRRGT DVFKALALGA 300
QAVLIGRPII YGLAAKGEDG VKKVIDMLKN EFEITMALSG CPTIDDITRN 350
HVRTENERLH SML 363
Length:363
Mass (Da):40,130
Last modified:April 18, 2006 - v1
Checksum:i8AA94B1A354BA60C
GO

Sequence cautioni

The sequence BAB02979.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871P → L in AAM67194. 1 Publication
Sequence conflicti309 – 3091I → M in AAM67194. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000600 Genomic DNA. Translation: BAB02979.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75477.1.
CP002686 Genomic DNA. Translation: AEE75478.1.
BT024891 mRNA. Translation: ABD85162.1.
AY088888 mRNA. Translation: AAM67194.1.
RefSeqiNP_001078152.1. NM_001084683.1.
NP_188031.1. NM_112271.3.
UniGeneiAt.39282.

Genome annotation databases

EnsemblPlantsiAT3G14150.1; AT3G14150.1; AT3G14150.
AT3G14150.2; AT3G14150.2; AT3G14150.
GeneIDi820632.
KEGGiath:AT3G14150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000600 Genomic DNA. Translation: BAB02979.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE75477.1 .
CP002686 Genomic DNA. Translation: AEE75478.1 .
BT024891 mRNA. Translation: ABD85162.1 .
AY088888 mRNA. Translation: AAM67194.1 .
RefSeqi NP_001078152.1. NM_001084683.1.
NP_188031.1. NM_112271.3.
UniGenei At.39282.

3D structure databases

ProteinModelPortali Q24JJ8.
SMRi Q24JJ8. Positions 3-355.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT3G14150.1-P.

Proteomic databases

PaxDbi Q24JJ8.
PRIDEi Q24JJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G14150.1 ; AT3G14150.1 ; AT3G14150 .
AT3G14150.2 ; AT3G14150.2 ; AT3G14150 .
GeneIDi 820632.
KEGGi ath:AT3G14150.

Organism-specific databases

TAIRi AT3G14150.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217463.
InParanoidi Q24JJ8.
KOi K11517.
OMAi YVQHAEA.
PhylomeDBi Q24JJ8.

Enzyme and pathway databases

UniPathwayi UPA00951 ; UER00912 .
BioCyci ARA:AT3G14150-MONOMER.
ARA:GQT-2460-MONOMER.

Miscellaneous databases

PROi Q24JJ8.

Gene expression databases

Genevestigatori Q24JJ8.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Shinn P., Chen H., Kim C.J., Ecker J.R.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Inducible antisense suppression of glycolate oxidase reveals its strong regulation over photosynthesis in rice."
    Xu H.-W., Zhang J., Zeng J., Jiang L., Liu E., Peng C., He Z.-H., Peng X.-X.
    J. Exp. Bot. 60:1799-1809(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiGLO3_ARATH
AccessioniPrimary (citable) accession number: Q24JJ8
Secondary accession number(s): Q8L8P3, Q9LJH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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