Q24FD9 (Q24FD9_TETTS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

ORF Names:

TTHERM_00865240 EMBL EAS06519.1

Organism

Tetrahymena thermophila (strain SB210) [Reference proteome]

Taxonomic identifier

312017 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena › Tetrahymena thermophila

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617 EMBL EAS06519.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW lagging strand elongation Inferred from Biological aspect of Ancestor. Source: RefGenome nucleotide-excision repair Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	chromosome Inferred from Biological aspect of Ancestor. Source: RefGenome mitochondrion Inferred from Biological aspect of Ancestor. Source: RefGenome nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q24FD9 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 921FCCCB18862EEA	FASTA	635	73,453
	10 20 30 40 50 60 MIKKLLYLPK QSLLSSLIFS KFCTQFNSKS IQSFYFLAKQ FDDISKISSR NSGIEAIETL 70 80 90 100 110 120 MNDYIQGGDN ELFIQMVRLL TCKVDSEEIQ IANSSLVEIL KVVYPQEDIT KFLFEKGDIG 130 140 150 160 170 180 LYAKEMLEKK LEKEGNNRTE KNHLSILEVT SFFEKLKNLQ GDRSRLEKQE LIIDFLKKIQ 190 200 210 220 230 240 DPLEIQYFIR ILSKSLRIGV SEKSIIKALT NINKKKKNSL DSLLKNVQDK IFGYNTALHT 250 260 270 280 290 300 DIQIGTPVPP MLAKPVSDFD ELLKFLKKYE SKKVSLELKY DGERCQVHYG KKKGIKLFSR 310 320 330 340 350 360 NLEIQNEKYP QLVQQLEKYF QKNNSVEDCI LDGEIVVTDS KGNIKSFQEQ QQNRKRKQDS 370 380 390 400 410 420 NKVVAFDEDN IEKIYLFDIL FLNACEQNTK EQLYRKSLIK ENFPIEGPVN HAESKIFDLS 430 440 450 460 470 480 IQKDFDELKK LVKQYIDQKE EGAMVKSLDS NTFYDNNGRT QWAKLKKQVL SGGLADTFDV 490 500 510 520 530 540 IPIAAYYGKG KRSGVYGSYL LACYDDKKKE YVALCKIGTG FSDQFLQDST DRLKQKVCSQ 550 560 570 580 590 600 KPKEYSVHRT FKPDVWFQKD AEVWEVESDS LSSSPIYTIG KMNYSDNGIS LRFPRFLRVR 610 620 630 DDKTTEQSTK TYQNNSKDQK GDHGDKGEEE EEGDK

References

[1]

"Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote." Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M. , Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L., Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z., Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A., Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A., Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A., Hamilton E.P., Orias E. PLoS Biol. 4:1620-1642(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB210.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG662285 Genomic DNA. Translation: EAS06519.1.
RefSeq	XP_001026764.1. XM_001026764.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5911.XP_001026764.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	EAS06519; EAS06519; TTHERM_00865240.
GeneID	7839837.
KEGG	tet:TTHERM_00865240.
Phylogenomic databases
KO	K01971.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit.
InterPro	IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF117018. SSF117018. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS00697. DNA_LIGASE_A1. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q24FD9_TETTS

Accession

Primary (citable) accession number: Q24FD9

Entry history

Integrated into UniProtKB/TrEMBL:	April 18, 2006
Last sequence update:	April 18, 2006
Last modified:	April 3, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)