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Protein
Submitted name:

Cathepsin L-like protease

Gene
N/A
Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cathepsin L-like proteaseImported
OrganismiFasciola hepatica (Liver fluke)Imported
Taxonomic identifieri6192 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaPlagiorchiidaEchinostomataEchinostomatoideaFasciolidaeFasciola

Structurei

3D structure databases

ProteinModelPortaliQ24944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 80Inhibitor_I29InterPro annotationAdd BLAST60
Domaini108 – 321Pept_C1InterPro annotationAdd BLAST214

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFFVLAVLT VGVFASNDDL WHQWKRIYNK EYNGADDEHR RNIWGKNVKH
60 70 80 90 100
IQEHNLRHGL GLVTYKLGLN QFTDLTFEEF KAKYLIEIPR SSELLSRGIP
110 120 130 140 150
YKANKLAVPE SIDWRDYYYV TEVKDQGQCG SCWAFSTTGA VEGQFRKNER
160 170 180 190 200
ASASFSEQQL VDCTRDFGNY GCGGGYMENA YEYLKHNGLE TESYYPYQAV
210 220 230 240 250
EGPCQYDGRL AYAKVTGYYT VHSGDEIELK NLVGTEDLPA VALDADSDFM
260 270 280 290 300
MYQSGIYQSQ TCLPDRLTHA VLAVGYGSQD GTDYWIVKNS WGTWWGEDGY
310 320
IRFARNRGNM CGIASLASVP MVARFP
Length:326
Mass (Da):37,159
Last modified:November 1, 1996 - v1
Checksum:i33466F981DBEBA94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22765 mRNA. Translation: CAA80446.1.
PIRiT09259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22765 mRNA. Translation: CAA80446.1.
PIRiT09259.

3D structure databases

ProteinModelPortaliQ24944.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ24944_FASHE
AccessioniPrimary (citable) accession number: Q24944
Secondary accession number(s): P91728
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.