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Protein
Submitted name:

Cathepsin

Gene
N/A
Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPSiC01.142.

Names & Taxonomyi

Protein namesi
Submitted name:
CathepsinImported
OrganismiFasciola hepatica (Liver fluke)Imported
Taxonomic identifieri6192 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaPlagiorchiidaEchinostomataEchinostomatoideaFasciolidaeFasciola

Structurei

3D structure databases

ProteinModelPortaliQ24941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 80Inhibitor_I29InterPro annotationAdd BLAST60
Domaini108 – 321Pept_C1InterPro annotationAdd BLAST214

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVILTLLI VGVFASNDDL WHQWKRIYNK EYKGADDDHR RNIWEQNVKH
60 70 80 90 100
IQEHNLRHDL GLVTYKLGLN QFTDMTFEEF KAKYLTEMPR ASELLSHGIP
110 120 130 140 150
YKANKRAVPD RIDWRESGYV TEVKDQGGCG SCWAFSTTGA MEGQYMKNEK
160 170 180 190 200
TSISFSEQQL VDCSGPFGNY GCNGGLMENA YEYLKRFGLE TESSYPYRAV
210 220 230 240 250
EGQCRYNEQL GVAKVTGYYT VHSGDEVELQ NLVGCRRPAA VALDVESDFM
260 270 280 290 300
MYRSGIYQSQ TCSPDRLNHG VLAVGYGIQD GTDYWIVKNS WGTWWGEDGY
310 320
IRMVRKRGNM CGIASLASVP MVAQFP
Length:326
Mass (Da):37,177
Last modified:November 1, 1996 - v1
Checksum:i6CCEB77A10798081
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33772 mRNA. Translation: AAA29137.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33772 mRNA. Translation: AAA29137.1.

3D structure databases

ProteinModelPortaliQ24941.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC01.142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ24941_FASHE
AccessioniPrimary (citable) accession number: Q24941
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.