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Q24895 (GRP78_ECHMU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein

Short name=GRP-78
Gene names
Name:GRP78
OrganismEchinococcus multilocularis (Fox tapeworm)
Taxonomic identifier6211 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

Protein attributes

Sequence length649 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 64962978 kDa glucose-regulated protein
PRO_0000013574

Regions

Motif646 – 6494Prevents secretion from ER

Sequences

Sequence LengthMass (Da)Tools
Q24895 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 057E7D617D1D8418

FASTA64971,675
        10         20         30         40         50         60 
MGLSTYVGTF LLCILTLSHC KSGKEEYGTV IGIDLGTTYS CVGVFKNGRV EIIANDQGNR 

        70         80         90        100        110        120 
ITPSYVAFSG DGERLIGDAA KNQLTSNPKN TLFDAKRLIG RDYDDKDVQG DIKRYPFKVI 

       130        140        150        160        170        180 
NKNNKPYMKV QVGSEEKGFA PEEVSAMVLS KMKEIAEAYL GTEVTHAVVT VPAYFNDAQR 

       190        200        210        220        230        240 
QATKDAGAIA GLTVLRIINE PTAAAIAYGL DKKDTEKNIL VFDLGGGTFD VSLLTIDNGV 

       250        260        270        280        290        300 
FEVVATSGDT HLGGEDFDQR LIDYFVKLYK KKEGKDITKD DRAVQKLRRE VEKAKRTLST 

       310        320        330        340        350        360 
EHSTMIEIDN LFEGKDFSEP LTRARFEELN NDLFRSTLKP VMKVMEDSGL KKEDIDDIVL 

       370        380        390        400        410        420 
VGGSTRIPKI QQLVKEFFNV KEPSRGINPD EAVAYGAAVQ AGVISGVEDT GDIVLLDVCP 

       430        440        450        460        470        480 
LTMGIETVGG VMTKLIPRNT VIPTKKSQIF STAADNQPTV TIQVFEGERP MTKDNHFLGK 

       490        500        510        520        530        540 
FDLTGIPPAP RGLPQIEVTF EIDVNGILRV SAEDKGTGKK SNIVINKETN RLTPEEIERM 

       550        560        570        580        590        600 
IQDAEKFSDQ DKQVKERVEV RNDLESLAYS IKNQVKDKEK MGGKLSDDEI KTIEDAADEA 

       610        620        630        640 
IKWMENNPQA ETSDYKKQKA NLESVVQPIV SKLYEGAAPP TESTPKEEL 

« Hide

References

[1]"Molecular cloning and characterization of an Echinococcus multilocularis and Echinococcus granulosus stress protein homologous to the mammalian 78 kDa glucose regulated protein."
Muhlschlegel F., Frosch P., Castro A., Apfel H., Muller A., Frosch M.
Mol. Biochem. Parasitol. 74:245-250(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63604 mRNA. Translation: AAC37258.1.

3D structure databases

ProteinModelPortalQ24895.
SMRQ24895. Positions 28-569.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ24895.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
SUPFAMSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP78_ECHMU
AccessionPrimary (citable) accession number: Q24895
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families