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Q24895

- GRP78_ECHMU

UniProt

Q24895 - GRP78_ECHMU

Protein

78 kDa glucose-regulated protein

Gene

GRP78

Organism
Echinococcus multilocularis (Fox tapeworm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein
    Short name:
    GRP-78
    Gene namesi
    Name:GRP78
    OrganismiEchinococcus multilocularis (Fox tapeworm)
    Taxonomic identifieri6211 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 64962978 kDa glucose-regulated proteinPRO_0000013574Add
    BLAST

    Proteomic databases

    PRIDEiQ24895.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24895.
    SMRiQ24895. Positions 28-569.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi646 – 6494Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q24895-1 [UniParc]FASTAAdd to Basket

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    MGLSTYVGTF LLCILTLSHC KSGKEEYGTV IGIDLGTTYS CVGVFKNGRV    50
    EIIANDQGNR ITPSYVAFSG DGERLIGDAA KNQLTSNPKN TLFDAKRLIG 100
    RDYDDKDVQG DIKRYPFKVI NKNNKPYMKV QVGSEEKGFA PEEVSAMVLS 150
    KMKEIAEAYL GTEVTHAVVT VPAYFNDAQR QATKDAGAIA GLTVLRIINE 200
    PTAAAIAYGL DKKDTEKNIL VFDLGGGTFD VSLLTIDNGV FEVVATSGDT 250
    HLGGEDFDQR LIDYFVKLYK KKEGKDITKD DRAVQKLRRE VEKAKRTLST 300
    EHSTMIEIDN LFEGKDFSEP LTRARFEELN NDLFRSTLKP VMKVMEDSGL 350
    KKEDIDDIVL VGGSTRIPKI QQLVKEFFNV KEPSRGINPD EAVAYGAAVQ 400
    AGVISGVEDT GDIVLLDVCP LTMGIETVGG VMTKLIPRNT VIPTKKSQIF 450
    STAADNQPTV TIQVFEGERP MTKDNHFLGK FDLTGIPPAP RGLPQIEVTF 500
    EIDVNGILRV SAEDKGTGKK SNIVINKETN RLTPEEIERM IQDAEKFSDQ 550
    DKQVKERVEV RNDLESLAYS IKNQVKDKEK MGGKLSDDEI KTIEDAADEA 600
    IKWMENNPQA ETSDYKKQKA NLESVVQPIV SKLYEGAAPP TESTPKEEL 649
    Length:649
    Mass (Da):71,675
    Last modified:November 1, 1996 - v1
    Checksum:i057E7D617D1D8418
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63604 mRNA. Translation: AAC37258.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M63604 mRNA. Translation: AAC37258.1 .

    3D structure databases

    ProteinModelPortali Q24895.
    SMRi Q24895. Positions 28-569.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q24895.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of an Echinococcus multilocularis and Echinococcus granulosus stress protein homologous to the mammalian 78 kDa glucose regulated protein."
      Muhlschlegel F., Frosch P., Castro A., Apfel H., Muller A., Frosch M.
      Mol. Biochem. Parasitol. 74:245-250(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGRP78_ECHMU
    AccessioniPrimary (citable) accession number: Q24895
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3