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Q24857 (ADH3_ENTHI) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase 3

Short name=ADH
EC=1.1.1.2
Gene names
Name:ADH3
OrganismEntamoeba histolytica
Taxonomic identifier5759 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

NADP-dependent ADH activity.

Catalytic activity

An alcohol + NADP+ = an aldehyde + NADPH.

Sequence similarities

Belongs to the iron-containing alcohol dehydrogenase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Molecular functionalcohol dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Alcohol dehydrogenase 3
PRO_0000087836

Experimental info

Sequence conflict1931R → I in CAA88639. Ref.2
Sequence conflict235 – 2428TLENHQDY → HKKIIKTI in CAA88639. Ref.2
Sequence conflict273 – 28311Missing in CAA88639. Ref.2
Sequence conflict307 – 3093VMR → NE in CAA88639. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q24857 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 506FBBA933631FA9

FASTA39543,485
        10         20         30         40         50         60 
MTMLNFTYYN PVRLIYGKGS LDEIEKQHLI PEDARIMMTY GGGSIKKNGV YEEVLKHIKP 

        70         80         90        100        110        120 
IVEFGGIEPN PSHETCIKAI KIAKENKINF LVAVGGGSII DATKYIALGM EHTYSDDPYD 

       130        140        150        160        170        180 
ICLKGGKFKV NPAQAKIGVV LTIPATGSET NCWGVISRHA DKLKLPFNNE SVFPTWSIVD 

       190        200        210        220        230        240 
PCFTMSLPDN QIRNGLVDSF VHCIEQYIGN YHLNPVVEAE TEGVMRTIIG VSHKTLENHQ 

       250        260        270        280        290        300 
DYQARITFCY AATVALNMSL LCGVTLCGGA HAVGVTLCGG AHAVGHELTS YYGLAHGETL 

       310        320        330        340        350        360 
AITTPGVMRF NKEKNAKKLI QMGEQVFGIK NSTPEAAIEA TEKWFKSIGM KTRLSEWGKG 

       370        380        390 
KEEFETIARK FEGNPAGAHK DIDYKGCLQI LNDIY 

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References

[1]"Cloning and expression of a putative alcohol dehydrogenase gene of Entamoeba histolytica and its application to immunological examination."
Kimura A., Hara Y., Kimoto T., Okuno Y., Minekawa Y., Nakabayashi T.
Clin. Diagn. Lab. Immunol. 3:270-274(1996) [PubMed: 8705667] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ATCC 30459 / HM-1:IMSS.
[2]"Cloning and expression of an Entamoeba histolytica NAPD+(-)dependent alcohol dehydrogenase gene."
Rodriguez M.A., Baez-Camargo M., Delgadillo D.M., Orozco E.
Biochim. Biophys. Acta 1306:23-26(1996) [PubMed: 8611619] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 30459 / HM-1:IMSS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49910 mRNA. Translation: BAA08651.1.
Z48752 Genomic DNA. Translation: CAA88639.1.
PIRS68143.

3D structure databases

ProteinModelPortalQ24857.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEPS00913. ADH_IRON_1. False negative.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADH3_ENTHI
AccessionPrimary (citable) accession number: Q24857
Secondary accession number(s): Q94560
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 21, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families