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Q24798

- GRP78_ECHGR

UniProt

Q24798 - GRP78_ECHGR

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Protein

78 kDa glucose-regulated protein

Gene

GRP78

Organism
Echinococcus granulosus (Hydatid tapeworm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein
Short name:
GRP-78
Gene namesi
Name:GRP78
OrganismiEchinococcus granulosus (Hydatid tapeworm)
Taxonomic identifieri6210 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 65163178 kDa glucose-regulated proteinPRO_0000013573Add
BLAST

Proteomic databases

PRIDEiQ24798.

Structurei

3D structure databases

ProteinModelPortaliQ24798.
SMRiQ24798. Positions 28-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi648 – 6514Prevents secretion from ER

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24798-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGLSTYVGIF LLCILTLSRC KSGKEEYGTV IGIDLGTTYS CVGVFKNGRV
60 70 80 90 100
EIIANDQGNR ITPSYVAFSG DGERLIGDAA KNQLTSNPKN TLFDAKRLIG
110 120 130 140 150
RDYHDKDVQG DIKRYPFKVI NKNNKPYMKV QVGSEEKGFA PEEVSAMVLS
160 170 180 190 200
KMKEIAEAYL GTEVTHAVVT VPAYFNDAQR QATKDAGAIA GLTVLRIINE
210 220 230 240 250
PTAAAIAYGL EKKDTEKNIL VFDLGGGTFD VSLLTIDNGV FEVVATSGDT
260 270 280 290 300
HLGGEDFDQR LIDYFVKLYK KKEGKDITKD DRAVQKLRRE VEKAKRTLST
310 320 330 340 350
EHSTMIEIDN LFEGKDFSEP LTRARFEELN NDLFRSTLKP VMKVMEDSGL
360 370 380 390 400
KKEDIDDIVL VGGSTRIPKI QQLVKEFFNG KEPIRGINPD EAVAYGAAVQ
410 420 430 440 450
AGVISGVEDT GDIVLLDVCP LTMGIETVGG VMTKLIPRNT VIPTKKSQIF
460 470 480 490 500
STAADNQPTV TIQVFEGERP MTKDNHFLGK FDLTGIPPAP RGLPQIEVTF
510 520 530 540 550
EIDVNGILRV SAEDKGTGKK SNIVINKETN RITPEEIERM IQDAEKFSDQ
560 570 580 590 600
DKQVKERVEV RNDLESLAYS IKNQVKDKEK MGGKLSDDEI KTIEDAADEA
610 620 630 640 650
IKWMENNPQA ETSDYKKQKA NLESVVQPIV SKLYEGAAPP PPTESTPKEE

L
Length:651
Mass (Da):71,921
Last modified:November 1, 1996 - v1
Checksum:iE98DC737F54A16B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63605 mRNA. Translation: AAC37259.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63605 mRNA. Translation: AAC37259.1 .

3D structure databases

ProteinModelPortali Q24798.
SMRi Q24798. Positions 28-569.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q24798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of an Echinococcus multilocularis and Echinococcus granulosus stress protein homologous to the mammalian 78 kDa glucose regulated protein."
    Muhlschlegel F., Frosch P., Castro A., Apfel H., Muller A., Frosch M.
    Mol. Biochem. Parasitol. 74:245-250(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGRP78_ECHGR
AccessioniPrimary (citable) accession number: Q24798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3