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Q24798

- GRP78_ECHGR

UniProt

Q24798 - GRP78_ECHGR

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Protein
78 kDa glucose-regulated protein
Gene
GRP78
Organism
Echinococcus granulosus (Hydatid tapeworm)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein
Short name:
GRP-78
Gene namesi
Name:GRP78
OrganismiEchinococcus granulosus (Hydatid tapeworm)
Taxonomic identifieri6210 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeEchinococcus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 65163178 kDa glucose-regulated protein
PRO_0000013573Add
BLAST

Proteomic databases

PRIDEiQ24798.

Structurei

3D structure databases

ProteinModelPortaliQ24798.
SMRiQ24798. Positions 28-569.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi648 – 6514Prevents secretion from ER

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24798-1 [UniParc]FASTAAdd to Basket

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MGLSTYVGIF LLCILTLSRC KSGKEEYGTV IGIDLGTTYS CVGVFKNGRV    50
EIIANDQGNR ITPSYVAFSG DGERLIGDAA KNQLTSNPKN TLFDAKRLIG 100
RDYHDKDVQG DIKRYPFKVI NKNNKPYMKV QVGSEEKGFA PEEVSAMVLS 150
KMKEIAEAYL GTEVTHAVVT VPAYFNDAQR QATKDAGAIA GLTVLRIINE 200
PTAAAIAYGL EKKDTEKNIL VFDLGGGTFD VSLLTIDNGV FEVVATSGDT 250
HLGGEDFDQR LIDYFVKLYK KKEGKDITKD DRAVQKLRRE VEKAKRTLST 300
EHSTMIEIDN LFEGKDFSEP LTRARFEELN NDLFRSTLKP VMKVMEDSGL 350
KKEDIDDIVL VGGSTRIPKI QQLVKEFFNG KEPIRGINPD EAVAYGAAVQ 400
AGVISGVEDT GDIVLLDVCP LTMGIETVGG VMTKLIPRNT VIPTKKSQIF 450
STAADNQPTV TIQVFEGERP MTKDNHFLGK FDLTGIPPAP RGLPQIEVTF 500
EIDVNGILRV SAEDKGTGKK SNIVINKETN RITPEEIERM IQDAEKFSDQ 550
DKQVKERVEV RNDLESLAYS IKNQVKDKEK MGGKLSDDEI KTIEDAADEA 600
IKWMENNPQA ETSDYKKQKA NLESVVQPIV SKLYEGAAPP PPTESTPKEE 650
L 651
Length:651
Mass (Da):71,921
Last modified:November 1, 1996 - v1
Checksum:iE98DC737F54A16B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63605 mRNA. Translation: AAC37259.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M63605 mRNA. Translation: AAC37259.1 .

3D structure databases

ProteinModelPortali Q24798.
SMRi Q24798. Positions 28-569.
ModBasei Search...

Proteomic databases

PRIDEi Q24798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of an Echinococcus multilocularis and Echinococcus granulosus stress protein homologous to the mammalian 78 kDa glucose regulated protein."
    Muhlschlegel F., Frosch P., Castro A., Apfel H., Muller A., Frosch M.
    Mol. Biochem. Parasitol. 74:245-250(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGRP78_ECHGR
AccessioniPrimary (citable) accession number: Q24798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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