ID   ZEST_DROVI              Reviewed;         618 AA.
AC   Q24762;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-NOV-2011, entry version 47.
DE   RecName: Full=Regulatory protein zeste;
GN   Name=z;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=92123185; PubMed=1732733;
RA   Chen J.D., Chan C.S., Pirrotta V.;
RT   "Conserved DNA binding and self-association domains of the Drosophila
RT   zeste protein.";
RL   Mol. Cell. Biol. 12:598-608(1992).
CC   -!- FUNCTION: Involved in transvection phenomena (= synapsis-dependent
CC       gene expression), where the synaptic pairing of chromosomes
CC       carrying genes with which zeste interacts influences the
CC       expression of these genes. Zeste binds to DNA and stimulates
CC       transcription from a nearby promoter (By similarity).
CC   -!- SUBUNIT: Self-associates forming complexes of several hundred
CC       monomers (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
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DR   EMBL; M76700; AAA29052.1; -; Genomic_DNA.
DR   PIR; A42020; A42020.
DR   ProteinModelPortal; Q24762; -.
DR   STRING; Q24762; -.
DR   FlyBase; FBgn0013149; Dvir\z.
DR   InParanoid; Q24762; -.
DR   OrthoDB; EOG4WM3BG; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN         1    618       Regulatory protein zeste.
FT                                /FTId=PRO_0000066576.
FT   DNA_BIND     66    146       By similarity.
FT   COMPBIAS    171    468       Ala/Gln-rich (OPA repeat involved in
FT                                transcriptional activation or repression
FT                                at different target loci).
SQ   SEQUENCE   618 AA;  68102 MW;  3127180B10AFDC0B CRC64;
     MSAAGDAGAG AANGSNNVAV VQATVSVSGN ISVGDGSPNN NNNNNANGNT NGNSNNNGST
     AGSSKGQLPL TPRFTAEEKD VLYTLFHLHE EVIDIKHRKK QRNKYSVRDT WDKIVRDFNS
     HPHVSAMRNI KQIQKFWLNS RLRKQYPYRD GSASGGSAGL GKVGTVSASA QQQQQQQQQQ
     QQQQQQQHHD SVKVEPEYQI SPEASEHNPQ GEPFDEIEMD GNDVSEMEDD PLEAQQQQQQ
     QQQQQQQAAA QAQAEAQQQQ QQQSAVAEMQ KLQVSAAVAA ANASMLNTHR INVDSISAEK
     LTLNDLLHFK PARHDEIILQ IKHPTDATAT QIHTIPAQPQ QHTMATITAG GYNQQIISEI
     KPQQITLAQY QAQQHQQAQA RLRPGQAQQL AQQQLAAQQQ QLAVAAAAAH QQQNSSSAAA
     VVVQQHQQQQ QQQQHQQQQQ QQQVQQQQQQ QQQAAAAAAA VKMQLTGGTP TFTFSALPTV
     TAATSVPVTV PVPVTVPVTA APAAVSNVSV SGAGTLPTGA QQQLQLQQQQ QQQQQQQQQQ
     QQAGDSYEER INYFKVKEAE LRCKEQQLAT EAKKIELNKA QDELKYMREV HRLRVEELKM
     KIRILQKEEE QLQKCSST
//