Q24762 (ZEST_DROVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulatory protein zeste

Gene names

Name:

z

Organism

Drosophila virilis (Fruit fly)

Taxonomic identifier

7244 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila

Protein attributes

Sequence length	618 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter By similarity.
Subunit structure	Self-associates forming complexes of several hundred monomers By similarity.
Subcellular location	Nucleus By similarity.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 618	618	Regulatory protein zeste		PRO_0000066576
Regions
	DNA binding	66 – 146	81	By similarity
	Compositional bias	171 – 468	298	Ala/Gln-rich (OPA repeat involved in transcriptional activation or repression at different target loci)

Sequences

	Sequence		Length	Mass (Da)
	Q24762 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3127180B10AFDC0B	FASTA	618	68,102
	10 20 30 40 50 60 MSAAGDAGAG AANGSNNVAV VQATVSVSGN ISVGDGSPNN NNNNNANGNT NGNSNNNGST 70 80 90 100 110 120 AGSSKGQLPL TPRFTAEEKD VLYTLFHLHE EVIDIKHRKK QRNKYSVRDT WDKIVRDFNS 130 140 150 160 170 180 HPHVSAMRNI KQIQKFWLNS RLRKQYPYRD GSASGGSAGL GKVGTVSASA QQQQQQQQQQ 190 200 210 220 230 240 QQQQQQQHHD SVKVEPEYQI SPEASEHNPQ GEPFDEIEMD GNDVSEMEDD PLEAQQQQQQ 250 260 270 280 290 300 QQQQQQQAAA QAQAEAQQQQ QQQSAVAEMQ KLQVSAAVAA ANASMLNTHR INVDSISAEK 310 320 330 340 350 360 LTLNDLLHFK PARHDEIILQ IKHPTDATAT QIHTIPAQPQ QHTMATITAG GYNQQIISEI 370 380 390 400 410 420 KPQQITLAQY QAQQHQQAQA RLRPGQAQQL AQQQLAAQQQ QLAVAAAAAH QQQNSSSAAA 430 440 450 460 470 480 VVVQQHQQQQ QQQQHQQQQQ QQQVQQQQQQ QQQAAAAAAA VKMQLTGGTP TFTFSALPTV 490 500 510 520 530 540 TAATSVPVTV PVPVTVPVTA APAAVSNVSV SGAGTLPTGA QQQLQLQQQQ QQQQQQQQQQ 550 560 570 580 590 600 QQAGDSYEER INYFKVKEAE LRCKEQQLAT EAKKIELNKA QDELKYMREV HRLRVEELKM 610 KIRILQKEEE QLQKCSST

References

[1]	"Conserved DNA binding and self-association domains of the Drosophila zeste protein." Chen J.D., Chan C.S., Pirrotta V. Mol. Cell. Biol. 12:598-608(1992) [PubMed: 1732733] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76700 Genomic DNA. Translation: AAA29052.1.
PIR	A42020.
3D structure databases
ProteinModelPortal	Q24762.
ModBase	Search...
Protein-protein interaction databases
STRING	Q24762.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0013149. Dvir\z.
Phylogenomic databases
InParanoid	Q24762.
OrthoDB	EOG4WM3BG.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ZEST_DROVI

Accession

Primary (citable) accession number: Q24762

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project