Q24708 (CSW_DROVI) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 76.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tyrosine-protein phosphatase corkscrew EC=3.1.3.48 | ||
| Gene names |
| ||
| Organism | Drosophila virilis (Fruit fly) | ||
| Taxonomic identifier | 7244 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila ›  |
Protein attributes
| Sequence length | 764 AA. |
| Sequence status | Fragment. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw By similarity. |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains at least 1 SH2 domain. Contains 1 tyrosine-protein phosphatase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Domain | SH2 domain |
| Molecular function | Developmental protein Hydrolase Protein phosphatase |
| Gene Ontology (GO) | |
| Biological_process | peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC terminal region determinationInferred from sequence or structural similarity. Source: UniProtKB torso signaling pathwayInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular_component | cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular_function | protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – 764 | ›764 | Tyrosine-protein phosphatase corkscrew | PRO_0000094852 | |||||
Regions | |||||||||
| Domain | 1 – 95 | 95 | SH2 | ||||||
| Domain | 117 – 522 | 406 | Tyrosine-protein phosphatase | ||||||
| Region | 174 – 325 | 152 | PTPase insert (Cys/Ser-rich) | ||||||
| Region | 460 – 466 | 7 | Substrate binding By similarity | ||||||
| Compositional bias | 186 – 191 | 6 | Poly-Ser | ||||||
| Compositional bias | 278 – 281 | 4 | Poly-Ala | ||||||
| Compositional bias | 576 – 600 | 25 | Ala-rich | ||||||
| Compositional bias | 613 – 616 | 4 | Poly-Asn | ||||||
| Compositional bias | 617 – 656 | 40 | Ser-rich | ||||||
| Compositional bias | 687 – 690 | 4 | Poly-Gln | ||||||
| Compositional bias | 694 – 753 | 60 | Ala-rich | ||||||
| Compositional bias | 755 – 761 | 7 | Poly-Pro | ||||||
Sites | |||||||||
| Active site | 460 | 1 | Phosphocysteine intermediate By similarity | ||||||
| Binding site | 422 | 1 | Substrate By similarity | ||||||
| Binding site | 507 | 1 | Substrate By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 1 | 1 | |||||||
Sequences
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References
| [1] | "The role of the Drosophila corkscrew protein as a transducer downstream of receptor tyrosine kinases is functionally conserved." Melnick M.B., Melnick C.B., Larsen I., Perrimon N., Perkins L.A. Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U22356 Genomic DNA. Translation: AAB02545.1. |
3D structure databases | |
| ProteinModelPortal | Q24708. |
| SMR | Q24708. Positions 1-174, 324-529. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0016496. Dvir\csw. |
Phylogenomic databases | |
| eggNOG | COG5599. |
| InParanoid | Q24708. |
| OrthoDB | EOG4PVMDK. |
Family and domain databases | |
| Gene3D | 3.30.505.10. 1 hit. |
| InterPro | IPR000980. SH2. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view] |
| Pfam | PF00017. SH2. 1 hit. PF00102. Y_phosphatase. 1 hit. [Graphical view] |
| PRINTS | PR00700. PRTYPHPHTASE. PR00401. SH2DOMAIN. |
| SMART | SM00194. PTPc. 1 hit. SM00252. SH2. 1 hit. [Graphical view] |
| PROSITE | PS50001. SH2. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CSW_DROVI | ||||||||
| Accession | Primary (citable) accession number: Q24708 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |