Reviewed,
UniProtKB/Swiss-Prot Q24708 (CSW_DROVI)
Last modified
July 28, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tyrosine-protein phosphatase corkscrew EC=3.1.3.48 | ||
| Gene names |
| ||
| Organism | Drosophila virilis (Fruit fly) | ||
| Taxonomic identifier | 7244 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila |
Protein attributes
| Sequence length | 764 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw By similarity. |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains at least 1 SH2 domain. Contains 1 tyrosine-protein phosphatase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Domain | SH2 domain |
| Molecular function | Developmental protein Hydrolase Protein phosphatase |
| Gene Ontology (GO) | |
| Biological process | protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro terminal region determinationInferred from sequence or structural similarity. Source: UniProtKB torso signaling pathwayInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | ‹1 – 764 | ›764 | Tyrosine-protein phosphatase corkscrew | PRO_0000094852 | |||||
Regions | |||||||||
| Domain | 1 – 95 | 95 | SH2 | ||||||
| Domain | 117 – 522 | 406 | Tyrosine-protein phosphatase | ||||||
| Region | 174 – 325 | 152 | PTPase insert (Cys/Ser-rich) | ||||||
| Compositional bias | 186 – 191 | 6 | Poly-Ser | ||||||
| Compositional bias | 278 – 281 | 4 | Poly-Ala | ||||||
| Compositional bias | 576 – 600 | 25 | Ala-rich | ||||||
| Compositional bias | 613 – 616 | 4 | Poly-Asn | ||||||
| Compositional bias | 617 – 656 | 40 | Ser-rich | ||||||
| Compositional bias | 687 – 690 | 4 | Poly-Gln | ||||||
| Compositional bias | 694 – 753 | 60 | Ala-rich | ||||||
| Compositional bias | 755 – 761 | 7 | Poly-Pro | ||||||
Sites | |||||||||
| Active site | 460 | 1 | Phosphocysteine intermediate By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 1 | 1 | |||||||
Sequences
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References
| [1] | "The role of the Drosophila corkscrew protein as a transducer downstream of receptor tyrosine kinases is functionally conserved." Melnick M.B., Melnick C.B., Larsen I., Perrimon N., Perkins L.A. Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U22356 Genomic DNA. Translation: AAB02545.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 2SHP based on UniProtKB Q06124. |
| SMR | Q24708. Positions 1-174. |
| ModBase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0016496. Dvir\csw. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.48. 141708. |
Family and domain databases | |
| InterPro | IPR000387. Dual-sp/Tyr_phosphatase. IPR000980. SH2. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view] |
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. |
| Pfam | PF00017. SH2. 1 hit. PF00102. Y_phosphatase. 1 hit. [Graphical view] |
| PRINTS | PR00700. PRTYPHPHTASE. PR00401. SH2DOMAIN. |
| ProDom | PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00194. PTPc. 1 hit. SM00252. SH2. 1 hit. [Graphical view] |
| PROSITE | PS50001. SH2. 1 hit. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CSW_DROVI | ||||||||
| Accession | Primary (citable) accession number: Q24708 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


