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Q24708

- CSW_DROVI

UniProt

Q24708 - CSW_DROVI

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Protein

Tyrosine-protein phosphatase corkscrew

Gene

csw

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei422 – 4221SubstrateBy similarity
Active sitei460 – 4601Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei507 – 5071SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. terminal region determination Source: UniProtKB
  2. torso signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase corkscrew (EC:3.1.3.48)
Gene namesi
Name:csw
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Organism-specific databases

FlyBaseiFBgn0016496. Dvir\csw.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 764›764Tyrosine-protein phosphatase corkscrewPRO_0000094852Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ24708.
SMRiQ24708. Positions 1-174, 324-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9595SH2PROSITE-ProRule annotationAdd
BLAST
Domaini117 – 522406Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 325152PTPase insert (Cys/Ser-rich)Add
BLAST
Regioni460 – 4667Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi186 – 1916Poly-Ser
Compositional biasi278 – 2814Poly-Ala
Compositional biasi576 – 60025Ala-richAdd
BLAST
Compositional biasi613 – 6164Poly-Asn
Compositional biasi617 – 65640Ser-richAdd
BLAST
Compositional biasi687 – 6904Poly-Gln
Compositional biasi694 – 75360Ala-richAdd
BLAST
Compositional biasi755 – 7617Poly-Pro

Sequence similaritiesi

Contains at least 1 SH2 domain.Curated
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiCOG5599.
OrthoDBiEOG7NPFST.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTiSM00194. PTPc. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q24708-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
WFHGNLSGKE AEKLILERGK NGSFLVRESQ SKPGDFVLSV RTDDKVTHVM
60 70 80 90 100
IRWQDKKYDV GGGESFATLS ELIEHYKRHP MVETCGTVVH LRQPFNATRI
110 120 130 140 150
TAAGINARVE QLVKGGFWEE FESLQQDSRD TFSRHEGYKD ENRLKNRYHD
160 170 180 190 200
HTRVKLQDVE RSAPGAEYIN ANYIRLPTDG DLYNMSSSSE SLNSTVAACP
210 220 230 240 250
ACTAAQTQRN CPNCHLLNKT CVKCAVKSAT LPTNCATCNR KSDSLSKHKR
260 270 280 290 300
SESMSASANA SAAGTGPGTP TAAGNTSAAA ALNGCLAVLL KKHCGDASPP
310 320 330 340 350
PSTTSSCSGP LTGSLLNGEG NQFKTYIATQ GCLANTKTDF WNMIWQENTR
360 370 380 390 400
VIVMTTKEIE RGKTKCERYW PDEGQCKQFG HAKVHCIKEN STNDYTLREF
410 420 430 440 450
LFSWRDKPER RIYHYHFQVW PDHGVPADPG CVLNFLQDVN TKQSSLAQAG
460 470 480 490 500
EKPGPICVHC SAGIGRTGTF IVIDMILDQI VRNGLDTEID IQRTIQMVRS
510 520 530 540 550
QRSGMVQTEA QYKFVYYAVQ HYIQTLIARK RAEEQSLQVG REYTNIKYTG
560 570 580 590 600
EIGNDSQRSP LPPAISNLSL VSCKSAVAEP LTAAAAAAAV AANAGNKHAA
610 620 630 640 650
KLQPPLPPLG ASNNNNSSGN SGSYCNSSSS TSTAQHNGVV SSSNNCSSGS
660 670 680 690 700
GSANSSNANG NGNILGNGSN MRKSNFYSDS LAALKLQQQQ LHDAATAAAA
710 720 730 740 750
AALASAAAPA ATTTAASASA AAAAAAAAKY KNIPKDMNSL RQPHAAYVAA
760
APALPPPPTP PRKT
Length:764
Mass (Da):82,126
Last modified:November 1, 1996 - v1
Checksum:i66008EA8560A2F7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22356 Genomic DNA. Translation: AAB02545.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22356 Genomic DNA. Translation: AAB02545.1 .

3D structure databases

ProteinModelPortali Q24708.
SMRi Q24708. Positions 1-174, 324-529.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0016496. Dvir\csw.

Phylogenomic databases

eggNOGi COG5599.
OrthoDBi EOG7NPFST.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
3.90.190.10. 2 hits.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00017. SH2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTi SM00194. PTPc. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The role of the Drosophila corkscrew protein as a transducer downstream of receptor tyrosine kinases is functionally conserved."
    Melnick M.B., Melnick C.B., Larsen I., Perrimon N., Perkins L.A.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCSW_DROVI
AccessioniPrimary (citable) accession number: Q24708
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3