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Q24708

- CSW_DROVI

UniProt

Q24708 - CSW_DROVI

Protein

Tyrosine-protein phosphatase corkscrew

Gene

csw

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei422 – 4221SubstrateBy similarity
    Active sitei460 – 4601Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei507 – 5071SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. terminal region determination Source: UniProtKB
    2. torso signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase corkscrew (EC:3.1.3.48)
    Gene namesi
    Name:csw
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

    Organism-specific databases

    FlyBaseiFBgn0016496. Dvir\csw.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 764›764Tyrosine-protein phosphatase corkscrewPRO_0000094852Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ24708.
    SMRiQ24708. Positions 1-174, 324-529.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9595SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini117 – 522406Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni174 – 325152PTPase insert (Cys/Ser-rich)Add
    BLAST
    Regioni460 – 4667Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi186 – 1916Poly-Ser
    Compositional biasi278 – 2814Poly-Ala
    Compositional biasi576 – 60025Ala-richAdd
    BLAST
    Compositional biasi613 – 6164Poly-Asn
    Compositional biasi617 – 65640Ser-richAdd
    BLAST
    Compositional biasi687 – 6904Poly-Gln
    Compositional biasi694 – 75360Ala-richAdd
    BLAST
    Compositional biasi755 – 7617Poly-Pro

    Sequence similaritiesi

    Contains at least 1 SH2 domain.Curated
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiCOG5599.
    InParanoidiQ24708.
    OrthoDBiEOG7NPFST.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    3.90.190.10. 2 hits.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000980. SH2.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    PR00401. SH2DOMAIN.
    SMARTiSM00194. PTPc. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q24708-1 [UniParc]FASTAAdd to Basket

    « Hide

    WFHGNLSGKE AEKLILERGK NGSFLVRESQ SKPGDFVLSV RTDDKVTHVM    50
    IRWQDKKYDV GGGESFATLS ELIEHYKRHP MVETCGTVVH LRQPFNATRI 100
    TAAGINARVE QLVKGGFWEE FESLQQDSRD TFSRHEGYKD ENRLKNRYHD 150
    HTRVKLQDVE RSAPGAEYIN ANYIRLPTDG DLYNMSSSSE SLNSTVAACP 200
    ACTAAQTQRN CPNCHLLNKT CVKCAVKSAT LPTNCATCNR KSDSLSKHKR 250
    SESMSASANA SAAGTGPGTP TAAGNTSAAA ALNGCLAVLL KKHCGDASPP 300
    PSTTSSCSGP LTGSLLNGEG NQFKTYIATQ GCLANTKTDF WNMIWQENTR 350
    VIVMTTKEIE RGKTKCERYW PDEGQCKQFG HAKVHCIKEN STNDYTLREF 400
    LFSWRDKPER RIYHYHFQVW PDHGVPADPG CVLNFLQDVN TKQSSLAQAG 450
    EKPGPICVHC SAGIGRTGTF IVIDMILDQI VRNGLDTEID IQRTIQMVRS 500
    QRSGMVQTEA QYKFVYYAVQ HYIQTLIARK RAEEQSLQVG REYTNIKYTG 550
    EIGNDSQRSP LPPAISNLSL VSCKSAVAEP LTAAAAAAAV AANAGNKHAA 600
    KLQPPLPPLG ASNNNNSSGN SGSYCNSSSS TSTAQHNGVV SSSNNCSSGS 650
    GSANSSNANG NGNILGNGSN MRKSNFYSDS LAALKLQQQQ LHDAATAAAA 700
    AALASAAAPA ATTTAASASA AAAAAAAAKY KNIPKDMNSL RQPHAAYVAA 750
    APALPPPPTP PRKT 764
    Length:764
    Mass (Da):82,126
    Last modified:November 1, 1996 - v1
    Checksum:i66008EA8560A2F7D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22356 Genomic DNA. Translation: AAB02545.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U22356 Genomic DNA. Translation: AAB02545.1 .

    3D structure databases

    ProteinModelPortali Q24708.
    SMRi Q24708. Positions 1-174, 324-529.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0016496. Dvir\csw.

    Phylogenomic databases

    eggNOGi COG5599.
    InParanoidi Q24708.
    OrthoDBi EOG7NPFST.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    3.90.190.10. 2 hits.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000980. SH2.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    PR00401. SH2DOMAIN.
    SMARTi SM00194. PTPc. 1 hit.
    SM00252. SH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The role of the Drosophila corkscrew protein as a transducer downstream of receptor tyrosine kinases is functionally conserved."
      Melnick M.B., Melnick C.B., Larsen I., Perrimon N., Perkins L.A.
      Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCSW_DROVI
    AccessioniPrimary (citable) accession number: Q24708
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3