Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q24708 (CSW_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase corkscrew

EC=3.1.3.48
Gene names
Name:csw
OrganismDrosophila virilis (Fruit fly)
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length764 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains at least 1 SH2 domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 764›764Tyrosine-protein phosphatase corkscrew
PRO_0000094852

Regions

Domain1 – 9595SH2
Domain117 – 522406Tyrosine-protein phosphatase
Region174 – 325152PTPase insert (Cys/Ser-rich)
Region460 – 4667Substrate binding By similarity
Compositional bias186 – 1916Poly-Ser
Compositional bias278 – 2814Poly-Ala
Compositional bias576 – 60025Ala-rich
Compositional bias613 – 6164Poly-Asn
Compositional bias617 – 65640Ser-rich
Compositional bias687 – 6904Poly-Gln
Compositional bias694 – 75360Ala-rich
Compositional bias755 – 7617Poly-Pro

Sites

Active site4601Phosphocysteine intermediate By similarity
Binding site4221Substrate By similarity
Binding site5071Substrate By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q24708 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 66008EA8560A2F7D

FASTA76482,126
        10         20         30         40         50         60 
WFHGNLSGKE AEKLILERGK NGSFLVRESQ SKPGDFVLSV RTDDKVTHVM IRWQDKKYDV 

        70         80         90        100        110        120 
GGGESFATLS ELIEHYKRHP MVETCGTVVH LRQPFNATRI TAAGINARVE QLVKGGFWEE 

       130        140        150        160        170        180 
FESLQQDSRD TFSRHEGYKD ENRLKNRYHD HTRVKLQDVE RSAPGAEYIN ANYIRLPTDG 

       190        200        210        220        230        240 
DLYNMSSSSE SLNSTVAACP ACTAAQTQRN CPNCHLLNKT CVKCAVKSAT LPTNCATCNR 

       250        260        270        280        290        300 
KSDSLSKHKR SESMSASANA SAAGTGPGTP TAAGNTSAAA ALNGCLAVLL KKHCGDASPP 

       310        320        330        340        350        360 
PSTTSSCSGP LTGSLLNGEG NQFKTYIATQ GCLANTKTDF WNMIWQENTR VIVMTTKEIE 

       370        380        390        400        410        420 
RGKTKCERYW PDEGQCKQFG HAKVHCIKEN STNDYTLREF LFSWRDKPER RIYHYHFQVW 

       430        440        450        460        470        480 
PDHGVPADPG CVLNFLQDVN TKQSSLAQAG EKPGPICVHC SAGIGRTGTF IVIDMILDQI 

       490        500        510        520        530        540 
VRNGLDTEID IQRTIQMVRS QRSGMVQTEA QYKFVYYAVQ HYIQTLIARK RAEEQSLQVG 

       550        560        570        580        590        600 
REYTNIKYTG EIGNDSQRSP LPPAISNLSL VSCKSAVAEP LTAAAAAAAV AANAGNKHAA 

       610        620        630        640        650        660 
KLQPPLPPLG ASNNNNSSGN SGSYCNSSSS TSTAQHNGVV SSSNNCSSGS GSANSSNANG 

       670        680        690        700        710        720 
NGNILGNGSN MRKSNFYSDS LAALKLQQQQ LHDAATAAAA AALASAAAPA ATTTAASASA 

       730        740        750        760 
AAAAAAAAKY KNIPKDMNSL RQPHAAYVAA APALPPPPTP PRKT 

« Hide

References

[1]"The role of the Drosophila corkscrew protein as a transducer downstream of receptor tyrosine kinases is functionally conserved."
Melnick M.B., Melnick C.B., Larsen I., Perrimon N., Perkins L.A.
Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U22356 Genomic DNA. Translation: AAB02545.1.

3D structure databases

ProteinModelPortalQ24708.
SMRQ24708. Positions 1-174, 324-529.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0016496. Dvir\csw.

Phylogenomic databases

eggNOGCOG5599.
InParanoidQ24708.
OrthoDBEOG7NPFST.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00017. SH2. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
PR00401. SH2DOMAIN.
SMARTSM00194. PTPc. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
PROSITEPS50001. SH2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCSW_DROVI
AccessionPrimary (citable) accession number: Q24708
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase