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Q24705

- PDM2_DROVI

UniProt

Q24705 - PDM2_DROVI

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Protein

POU domain protein 2

Gene

pdm2

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi362 – 42160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain protein 2
Alternative name(s):
Miti-mere
Pdm-2
Protein didymous
dOct2
dPOU-28
Gene namesi
Name:pdm2
Synonyms:dim, OCT2, pdm-2, POU-28
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Organism-specific databases

FlyBaseiFBgn0020449. Dvir\pdm2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 471›471POU domain protein 2PRO_0000100779Add
BLAST

Expressioni

Developmental stagei

Expressed primarily during the first half of embryogenesis. Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.

Structurei

3D structure databases

ProteinModelPortaliQ24705.
SMRiQ24705. Positions 261-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini257 – 33175POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 127Poly-Glu
Compositional biasi70 – 734Poly-Ala
Compositional biasi218 – 2236Poly-Gln

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG267922.
OrthoDBiEOG7DJSMG.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q24705-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
CGKSYEEEEE EEDDELEADV AQNLSSKRSA RQLDADMENE VLNLARSVSP
60 70 80 90 100
AAKRLALEHT AEPALAAQSA AAATPPVGLS LPPTAPLGFG PEDMQQALQL
110 120 130 140 150
QLHSYIEMVR QLAPDAFPNP NLATQFLLQN SLQALAQFQA LQQLKQQRDQ
160 170 180 190 200
QLPTASEQLP TRHYSTPLSK SPLRSPSLSP VARSMEPQQA QRTPPNSLAA
210 220 230 240 250
AGLGLSSAVL TPNTPSMQQQ QQQTMTSTTN ASSTPKPLAS GATVAAVMAT
260 270 280 290 300
KLEQSPEETT DLEELEQFAK TFKQRRIKLG FTQGDVGLAM GKLYGNDFSQ
310 320 330 340 350
TTISRFEALN LSFKNMCKLK PLLQKWLEDA DSSVAKSAGG VFNINTMTTN
360 370 380 390 400
LSSTPESILG RRRKKRTSIE TTIRGALEQA FVLNCKPTSE EINQLSERLH
410 420 430 440 450
MDKEVVRVWF CNRRQKEKRI NPSLDLDSPT GTPLSSHAFG YPPQALNMSN
460 470
GGHVLLEAGG SHCGSSISSG E
Length:471
Mass (Da):51,226
Last modified:November 1, 1996 - v1
Checksum:iB0D27F895EC2428C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14723 Genomic DNA. Translation: AAA21584.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14723 Genomic DNA. Translation: AAA21584.1 .

3D structure databases

ProteinModelPortali Q24705.
SMRi Q24705. Positions 261-422.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0020449. Dvir\pdm2.

Phylogenomic databases

eggNOGi NOG267922.
OrthoDBi EOG7DJSMG.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of complex expression domains of the pdm-2 POU domain gene between Drosophila virilis and Drosophila melanogaster."
    Poole S.J.
    Mech. Dev. 49:107-116(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Embryo.

Entry informationi

Entry nameiPDM2_DROVI
AccessioniPrimary (citable) accession number: Q24705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3