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Q24705

- PDM2_DROVI

UniProt

Q24705 - PDM2_DROVI

Protein

POU domain protein 2

Gene

pdm2

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi362 – 42160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain protein 2
    Alternative name(s):
    Miti-mere
    Pdm-2
    Protein didymous
    dOct2
    dPOU-28
    Gene namesi
    Name:pdm2
    Synonyms:dim, OCT2, pdm-2, POU-28
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

    Organism-specific databases

    FlyBaseiFBgn0020449. Dvir\pdm2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 471›471POU domain protein 2PRO_0000100779Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed primarily during the first half of embryogenesis. Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.

    Structurei

    3D structure databases

    ProteinModelPortaliQ24705.
    SMRiQ24705. Positions 261-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini257 – 33175POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 127Poly-Glu
    Compositional biasi70 – 734Poly-Ala
    Compositional biasi218 – 2236Poly-Gln

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    InParanoidiQ24705.
    OrthoDBiEOG7DJSMG.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q24705-1 [UniParc]FASTAAdd to Basket

    « Hide

    CGKSYEEEEE EEDDELEADV AQNLSSKRSA RQLDADMENE VLNLARSVSP    50
    AAKRLALEHT AEPALAAQSA AAATPPVGLS LPPTAPLGFG PEDMQQALQL 100
    QLHSYIEMVR QLAPDAFPNP NLATQFLLQN SLQALAQFQA LQQLKQQRDQ 150
    QLPTASEQLP TRHYSTPLSK SPLRSPSLSP VARSMEPQQA QRTPPNSLAA 200
    AGLGLSSAVL TPNTPSMQQQ QQQTMTSTTN ASSTPKPLAS GATVAAVMAT 250
    KLEQSPEETT DLEELEQFAK TFKQRRIKLG FTQGDVGLAM GKLYGNDFSQ 300
    TTISRFEALN LSFKNMCKLK PLLQKWLEDA DSSVAKSAGG VFNINTMTTN 350
    LSSTPESILG RRRKKRTSIE TTIRGALEQA FVLNCKPTSE EINQLSERLH 400
    MDKEVVRVWF CNRRQKEKRI NPSLDLDSPT GTPLSSHAFG YPPQALNMSN 450
    GGHVLLEAGG SHCGSSISSG E 471
    Length:471
    Mass (Da):51,226
    Last modified:November 1, 1996 - v1
    Checksum:iB0D27F895EC2428C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14723 Genomic DNA. Translation: AAA21584.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14723 Genomic DNA. Translation: AAA21584.1 .

    3D structure databases

    ProteinModelPortali Q24705.
    SMRi Q24705. Positions 261-422.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0020449. Dvir\pdm2.

    Phylogenomic databases

    eggNOGi NOG267922.
    InParanoidi Q24705.
    OrthoDBi EOG7DJSMG.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conservation of complex expression domains of the pdm-2 POU domain gene between Drosophila virilis and Drosophila melanogaster."
      Poole S.J.
      Mech. Dev. 49:107-116(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiPDM2_DROVI
    AccessioniPrimary (citable) accession number: Q24705
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3