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Q24705 (PDM2_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain protein 2
Alternative name(s):
Miti-mere
Pdm-2
Protein didymous
dOct2
dPOU-28
Gene names
Name:pdm2
Synonyms:dim, OCT2, pdm-2, POU-28
OrganismDrosophila virilis (Fruit fly)
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length471 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription By similarity.

Subcellular location

Nucleus.

Developmental stage

Expressed primarily during the first half of embryogenesis. Initial expression in cellular blastoderm stage, then in ectodermal stripes during germband extension. Broad expression in the neuroectoderm followed by limitation to discrete subsets of CNS cells, and expression in specific PNS neurons and support cells.

Sequence similarities

Belongs to the POU transcription factor family. Class-2 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 471›471POU domain protein 2
PRO_0000100779

Regions

Domain257 – 33175POU-specific
DNA binding362 – 42160Homeobox
Compositional bias6 – 127Poly-Glu
Compositional bias70 – 734Poly-Ala
Compositional bias218 – 2236Poly-Gln

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q24705 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B0D27F895EC2428C

FASTA47151,226
        10         20         30         40         50         60 
CGKSYEEEEE EEDDELEADV AQNLSSKRSA RQLDADMENE VLNLARSVSP AAKRLALEHT 

        70         80         90        100        110        120 
AEPALAAQSA AAATPPVGLS LPPTAPLGFG PEDMQQALQL QLHSYIEMVR QLAPDAFPNP 

       130        140        150        160        170        180 
NLATQFLLQN SLQALAQFQA LQQLKQQRDQ QLPTASEQLP TRHYSTPLSK SPLRSPSLSP 

       190        200        210        220        230        240 
VARSMEPQQA QRTPPNSLAA AGLGLSSAVL TPNTPSMQQQ QQQTMTSTTN ASSTPKPLAS 

       250        260        270        280        290        300 
GATVAAVMAT KLEQSPEETT DLEELEQFAK TFKQRRIKLG FTQGDVGLAM GKLYGNDFSQ 

       310        320        330        340        350        360 
TTISRFEALN LSFKNMCKLK PLLQKWLEDA DSSVAKSAGG VFNINTMTTN LSSTPESILG 

       370        380        390        400        410        420 
RRRKKRTSIE TTIRGALEQA FVLNCKPTSE EINQLSERLH MDKEVVRVWF CNRRQKEKRI 

       430        440        450        460        470 
NPSLDLDSPT GTPLSSHAFG YPPQALNMSN GGHVLLEAGG SHCGSSISSG E 

« Hide

References

[1]"Conservation of complex expression domains of the pdm-2 POU domain gene between Drosophila virilis and Drosophila melanogaster."
Poole S.J.
Mech. Dev. 49:107-116(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14723 Genomic DNA. Translation: AAA21584.1.

3D structure databases

ProteinModelPortalQ24705.
SMRQ24705. Positions 261-422.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0020449. Dvir\pdm2.

Phylogenomic databases

eggNOGNOG267922.
InParanoidQ24705.
OrthoDBEOG7DJSMG.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDM2_DROVI
AccessionPrimary (citable) accession number: Q24705
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase