Q24703 (UBX_DROVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeotic protein ultrabithorax

Gene names

Name:

Ubx

Organism

Drosophila virilis (Fruit fly)

Taxonomic identifier

7244 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Drosophila › virilis group

Protein attributes

Sequence length	87 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds the consensus region 5'-TTAAT[GT][GA]-3'. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor By similarity.
Subcellular location	Nucleus.
Tissue specificity	In the embryo, expression is seen in the epidermis, somatic and visceral mesoderm, and the peripheral and central nervous system. Ref.1
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Developmental protein Repressor
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Traceable author statement PubMed 1673656. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform IB (identifier: Q24703-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform IA (identifier: Q24703-2)

The sequence of this isoform differs from the canonical sequence as follows:
     30-38: Missing.

Isoform IIA (identifier: Q24703-3)

The sequence of this isoform differs from the canonical sequence as follows:
     30-55: Missing.

Isoform IIB (identifier: Q24703-4)

The sequence of this isoform differs from the canonical sequence as follows:
     39-55: Missing.

Isoform IVA (identifier: Q24703-5)

The sequence of this isoform differs from the canonical sequence as follows:
     30-72: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›87	›87	Homeotic protein ultrabithorax		PRO_0000200271
Regions
	Motif	22 – 27	6	Antp-type hexapeptide
	Compositional bias	3 – 6	4	Poly-Ala
Natural variations
	Alternative sequence	30 – 72	43	Missing in isoform IVA.		VSP_002412
	Alternative sequence	30 – 55	26	Missing in isoform IIA.		VSP_002411
	Alternative sequence	30 – 38	9	Missing in isoform IA.		VSP_002410
	Alternative sequence	39 – 55	17	Missing in isoform IIB.		VSP_002413
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	87	1

Sequences

	Sequence		Length	Mass (Da)
	Isoform IB [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 0EE2F29DFF12FFED	FASTA	87	9,307
	10 20 30 40 50 60 SGAAAAQTAA ASSLHQASNH TFYPWMAIAG ESTADPSKSK IRSDLTQYGG ISTDMGKRYS 70 80 ESLAGSLLPD WLGTNGLRRR GRQTYTR
	Isoform IA [UniParc]. Checksum: BF0ACB21EA7C3086	FASTA	78	8,434
	10 20 30 40 50 60 SGAAAAQTAA ASSLHQASNH TFYPWMAIAS KIRSDLTQYG GISTDMGKRY SESLAGSLLP 70 DWLGTNGLRR RGRQTYTR
	Isoform IIA [UniParc]. Checksum: 7487F77F60DBBB1E	FASTA	61	6,580
	10 20 30 40 50 60 SGAAAAQTAA ASSLHQASNH TFYPWMAIAG KRYSESLAGS LLPDWLGTNG LRRRGRQTYT R
	Isoform IIB [UniParc]. Checksum: 45C9AB4BC001F131	FASTA	70	7,453
	10 20 30 40 50 60 SGAAAAQTAA ASSLHQASNH TFYPWMAIAG ESTADPSKGK RYSESLAGSL LPDWLGTNGL 70 RRRGRQTYTR
	Isoform IVA [UniParc]. Checksum: E344758B02798AB5	FASTA	44	4,706
	10 20 30 40 SGAAAAQTAA ASSLHQASNH TFYPWMAIAG TNGLRRRGRQ TYTR

References

[1]	"Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila." Bomze H.M., Lopez A.J. Genetics 136:965-977(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U03180 mRNA. Translation: AAA03570.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0013100. Dvir\Ubx.
Phylogenomic databases
eggNOG	NOG252841.
InParanoid	Q24703.
Family and domain databases
InterPro	IPR001827. Homeobox_Antennapedia_CS. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBX_DROVI

Accession

Primary (citable) accession number: Q24703

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project