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Q24645

- ANTP_DROSU

UniProt

Q24645 - ANTP_DROSU

Protein

Homeotic protein antennapedia

Gene

Antp

Organism
Drosophila subobscura (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that regulates segmental identity in the mesothorax. Provides cells with specific positional identities on the anterior-posterior axis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi313 – 37260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior axis specification Source: UniProtKB
    2. specification of segmental identity, thorax Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeotic protein antennapedia
    Gene namesi
    Name:Antp
    OrganismiDrosophila subobscura (Fruit fly)
    Taxonomic identifieri7241 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0012932. Dsub\Antp.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Homeotic protein antennapediaPRO_0000200260Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ24645.
    SMRiQ24645. Positions 313-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi299 – 3046Antp-type hexapeptide

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi77 – 826Gln-rich (OPA repeat)
    Compositional biasi115 – 16854Gln-rich (OPA repeat)Add
    BLAST

    Sequence similaritiesi

    Belongs to the Antp homeobox family.1 Publication
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Repeat

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q24645-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMSTNNCES MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNPN    50
    HQGNMPYPRF PPYDRMPYYN GQGMDQQQQQ HQGYSRPDSP SSQVGGVMPQ 100
    AQTNGLPTGG QLVAQQQQQQ PQQQSQTPQQ QQAQQPQQQQ QQLQQLPQVT 150
    QQVTHPQQQQ QQQQQQQQPV VYASCKLQAA VGVGLGMVPE GGSPPLVDQM 200
    TGHHMNAQMS LPHHMGHPQA QLGYTDVGVP DVTEVHQNHH NMGMYGQQQT 250
    GVPPVGAPPQ AMMHQGQGPP QMHQGHLPGQ HTPPSQNPNS QSSGMPSPLY 300
    PWMRSQFGKC QERKRGRQTY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL 350
    CLTERQIKIW FQNRRMKWKK ENKTKGEPGS GGEGDEITPP NSPQ 394
    Length:394
    Mass (Da):44,550
    Last modified:November 1, 1996 - v1
    Checksum:iE45D2BBB9C01334B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60995, X62246 Genomic DNA. Translation: CAA43307.1.
    PIRiS26492.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60995 , X62246 Genomic DNA. Translation: CAA43307.1 .
    PIRi S26492.

    3D structure databases

    ProteinModelPortali Q24645.
    SMRi Q24645. Positions 313-379.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0012932. Dsub\Antp.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative studies of Drosophila Antennapedia genes."
      Hooper J.E., Perez-Alonso M., Bermingham J.R. Jr., Prout M., Rocklein B.A., Wagenbach M., Edstroem J.E., De Frutos R., Scott M.P.
      Genetics 132:453-469(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: H271.

    Entry informationi

    Entry nameiANTP_DROSU
    AccessioniPrimary (citable) accession number: Q24645
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3