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Q24645 (ANTP_DROSU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeotic protein antennapedia
Gene names
Name:Antp
OrganismDrosophila subobscura (Fruit fly)
Taxonomic identifier7241 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that regulates segmental identity in the mesothorax. Provides cells with specific positional identities on the anterior-posterior axis By similarity. UniProtKB P02833

Subcellular location

Nucleus Probable UniProtKB P02833.

Sequence similarities

Belongs to the Antp homeobox family. Ref.1

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Homeotic protein antennapedia
PRO_0000200260

Regions

DNA binding313 – 37260Homeobox
Motif299 – 3046Antp-type hexapeptide
Compositional bias77 – 826Gln-rich (OPA repeat)
Compositional bias115 – 16854Gln-rich (OPA repeat)

Sequences

Sequence LengthMass (Da)Tools
Q24645 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E45D2BBB9C01334B

FASTA39444,550
        10         20         30         40         50         60 
MTMSTNNCES MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNPN HQGNMPYPRF 

        70         80         90        100        110        120 
PPYDRMPYYN GQGMDQQQQQ HQGYSRPDSP SSQVGGVMPQ AQTNGLPTGG QLVAQQQQQQ 

       130        140        150        160        170        180 
PQQQSQTPQQ QQAQQPQQQQ QQLQQLPQVT QQVTHPQQQQ QQQQQQQQPV VYASCKLQAA 

       190        200        210        220        230        240 
VGVGLGMVPE GGSPPLVDQM TGHHMNAQMS LPHHMGHPQA QLGYTDVGVP DVTEVHQNHH 

       250        260        270        280        290        300 
NMGMYGQQQT GVPPVGAPPQ AMMHQGQGPP QMHQGHLPGQ HTPPSQNPNS QSSGMPSPLY 

       310        320        330        340        350        360 
PWMRSQFGKC QERKRGRQTY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL CLTERQIKIW 

       370        380        390 
FQNRRMKWKK ENKTKGEPGS GGEGDEITPP NSPQ 

« Hide

References

[1]"Comparative studies of Drosophila Antennapedia genes."
Hooper J.E., Perez-Alonso M., Bermingham J.R. Jr., Prout M., Rocklein B.A., Wagenbach M., Edstroem J.E., De Frutos R., Scott M.P.
Genetics 132:453-469(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: H271.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60995, X62246 Genomic DNA. Translation: CAA43307.1.
PIRS26492.

3D structure databases

ProteinModelPortalQ24645.
SMRQ24645. Positions 313-379.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0012932. Dsub\Antp.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameANTP_DROSU
AccessionPrimary (citable) accession number: Q24645
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase