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Protein

Homeotic protein antennapedia

Gene

Antp

Organism
Drosophila subobscura (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that regulates segmental identity in the mesothorax. Provides cells with specific positional identities on the anterior-posterior axis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi313 – 37260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior axis specification Source: UniProtKB
  2. specification of segmental identity, thorax Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein antennapedia
Gene namesi
Name:Antp
OrganismiDrosophila subobscura (Fruit fly)
Taxonomic identifieri7241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012932. Dsub\Antp.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Homeotic protein antennapediaPRO_0000200260Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ24645.
SMRiQ24645. Positions 313-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi299 – 3046Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 826Gln-rich (OPA repeat)
Compositional biasi115 – 16854Gln-rich (OPA repeat)Add
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.1 Publication
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24645-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMSTNNCES MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNPN
60 70 80 90 100
HQGNMPYPRF PPYDRMPYYN GQGMDQQQQQ HQGYSRPDSP SSQVGGVMPQ
110 120 130 140 150
AQTNGLPTGG QLVAQQQQQQ PQQQSQTPQQ QQAQQPQQQQ QQLQQLPQVT
160 170 180 190 200
QQVTHPQQQQ QQQQQQQQPV VYASCKLQAA VGVGLGMVPE GGSPPLVDQM
210 220 230 240 250
TGHHMNAQMS LPHHMGHPQA QLGYTDVGVP DVTEVHQNHH NMGMYGQQQT
260 270 280 290 300
GVPPVGAPPQ AMMHQGQGPP QMHQGHLPGQ HTPPSQNPNS QSSGMPSPLY
310 320 330 340 350
PWMRSQFGKC QERKRGRQTY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL
360 370 380 390
CLTERQIKIW FQNRRMKWKK ENKTKGEPGS GGEGDEITPP NSPQ
Length:394
Mass (Da):44,550
Last modified:November 1, 1996 - v1
Checksum:iE45D2BBB9C01334B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60995, X62246 Genomic DNA. Translation: CAA43307.1.
PIRiS26492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60995, X62246 Genomic DNA. Translation: CAA43307.1.
PIRiS26492.

3D structure databases

ProteinModelPortaliQ24645.
SMRiQ24645. Positions 313-379.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012932. Dsub\Antp.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative studies of Drosophila Antennapedia genes."
    Hooper J.E., Perez-Alonso M., Bermingham J.R. Jr., Prout M., Rocklein B.A., Wagenbach M., Edstroem J.E., De Frutos R., Scott M.P.
    Genetics 132:453-469(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: H271.

Entry informationi

Entry nameiANTP_DROSU
AccessioniPrimary (citable) accession number: Q24645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.