Q24645 (ANTP_DROSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeotic protein antennapedia

Gene names

Name:

Antp

Organism

Drosophila subobscura (Fruit fly)

Taxonomic identifier

7241 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › obscura group › obscura subgroup

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that regulates segmental identity in the mesothorax. Provides cells with specific positional identities on the anterior-posterior axis By similarity. UniProtKB P02833
Subcellular location	Nucleus Probable UniProtKB P02833.
Sequence similarities	Belongs to the Antp homeobox family. Ref.1 Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox Repeat
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	anterior/posterior axis specification Inferred from sequence or structural similarity Ref.1. Source: UniProtKB specification of segmental identity, thorax Inferred from sequence or structural similarity Ref.1. Source: UniProtKB
Cellular_component	nucleus Inferred from sequence or structural similarity Ref.1. Source: UniProtKB
Molecular_function	DNA binding Inferred from sequence or structural similarity Ref.1. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Homeotic protein antennapedia		PRO_0000200260
Regions
	DNA binding	313 – 372	60	Homeobox
	Motif	299 – 304	6	Antp-type hexapeptide
	Compositional bias	77 – 82	6	Gln-rich (OPA repeat)
	Compositional bias	115 – 168	54	Gln-rich (OPA repeat)

Sequences

	Sequence		Length	Mass (Da)
	Q24645 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E45D2BBB9C01334B	FASTA	394	44,550
	10 20 30 40 50 60 MTMSTNNCES MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNPN HQGNMPYPRF 70 80 90 100 110 120 PPYDRMPYYN GQGMDQQQQQ HQGYSRPDSP SSQVGGVMPQ AQTNGLPTGG QLVAQQQQQQ 130 140 150 160 170 180 PQQQSQTPQQ QQAQQPQQQQ QQLQQLPQVT QQVTHPQQQQ QQQQQQQQPV VYASCKLQAA 190 200 210 220 230 240 VGVGLGMVPE GGSPPLVDQM TGHHMNAQMS LPHHMGHPQA QLGYTDVGVP DVTEVHQNHH 250 260 270 280 290 300 NMGMYGQQQT GVPPVGAPPQ AMMHQGQGPP QMHQGHLPGQ HTPPSQNPNS QSSGMPSPLY 310 320 330 340 350 360 PWMRSQFGKC QERKRGRQTY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL CLTERQIKIW 370 380 390 FQNRRMKWKK ENKTKGEPGS GGEGDEITPP NSPQ

References

[1]	"Comparative studies of Drosophila Antennapedia genes." Hooper J.E., Perez-Alonso M., Bermingham J.R. Jr., Prout M., Rocklein B.A., Wagenbach M., Edstroem J.E., De Frutos R., Scott M.P. Genetics 132:453-469(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: H271.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X60995, X62246 Genomic DNA. Translation: CAA43307.1.
PIR	S26492.
3D structure databases
ProteinModelPortal	Q24645.
SMR	Q24645. Positions 313-379.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0012932. Dsub\Antp.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANTP_DROSU

Accession

Primary (citable) accession number: Q24645

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project