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Q24645

- ANTP_DROSU

UniProt

Q24645 - ANTP_DROSU

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Protein
Homeotic protein antennapedia
Gene
Antp
Organism
Drosophila subobscura (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that regulates segmental identity in the mesothorax. Provides cells with specific positional identities on the anterior-posterior axis By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi313 – 37260Homeobox
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior axis specification Source: UniProtKB
  2. specification of segmental identity, thorax Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein antennapedia
Gene namesi
Name:Antp
OrganismiDrosophila subobscura (Fruit fly)
Taxonomic identifieri7241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0012932. Dsub\Antp.

Subcellular locationi

Nucleus Inferred By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Homeotic protein antennapedia
PRO_0000200260Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ24645.
SMRiQ24645. Positions 313-379.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi299 – 3046Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 826Gln-rich (OPA repeat)
Compositional biasi115 – 16854Gln-rich (OPA repeat)
Add
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.1 Publication

Keywords - Domaini

Homeobox, Repeat

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q24645-1 [UniParc]FASTAAdd to Basket

« Hide

MTMSTNNCES MTSYFTNSYM GADMHHGHYP GNGVTDLDAQ QMHHYSQNPN    50
HQGNMPYPRF PPYDRMPYYN GQGMDQQQQQ HQGYSRPDSP SSQVGGVMPQ 100
AQTNGLPTGG QLVAQQQQQQ PQQQSQTPQQ QQAQQPQQQQ QQLQQLPQVT 150
QQVTHPQQQQ QQQQQQQQPV VYASCKLQAA VGVGLGMVPE GGSPPLVDQM 200
TGHHMNAQMS LPHHMGHPQA QLGYTDVGVP DVTEVHQNHH NMGMYGQQQT 250
GVPPVGAPPQ AMMHQGQGPP QMHQGHLPGQ HTPPSQNPNS QSSGMPSPLY 300
PWMRSQFGKC QERKRGRQTY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL 350
CLTERQIKIW FQNRRMKWKK ENKTKGEPGS GGEGDEITPP NSPQ 394
Length:394
Mass (Da):44,550
Last modified:November 1, 1996 - v1
Checksum:iE45D2BBB9C01334B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60995, X62246 Genomic DNA. Translation: CAA43307.1.
PIRiS26492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60995 , X62246 Genomic DNA. Translation: CAA43307.1 .
PIRi S26492.

3D structure databases

ProteinModelPortali Q24645.
SMRi Q24645. Positions 313-379.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0012932. Dsub\Antp.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative studies of Drosophila Antennapedia genes."
    Hooper J.E., Perez-Alonso M., Bermingham J.R. Jr., Prout M., Rocklein B.A., Wagenbach M., Edstroem J.E., De Frutos R., Scott M.P.
    Genetics 132:453-469(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: H271.

Entry informationi

Entry nameiANTP_DROSU
AccessioniPrimary (citable) accession number: Q24645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi