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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140SubstrateBy similarity1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 35NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GD23968
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000304 Componentsi: Chromosome 2L, Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012824. Dsim\Adh.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000544942 – 256Alcohol dehydrogenaseAdd BLAST255

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ24641.
SMRiQ24641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiQ24641.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q24641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTLTNKNV IFVAGLGGIG LDTSKELLKR DLKNLVILDR IENPAAIAEL
60 70 80 90 100
KAINPKVTVT FYPYDVTVPI AETTKLLKTI FAKLKTVDVL INGAGILDDH
110 120 130 140 150
QIERTIAVNY TGLVNTTTAI LDFWDKRKGG PGGIICNIGS VTGFNAIYQV
160 170 180 190 200
PVYSGTKAAV VNFTSSLAKL APITGVTAYT VNPGITRTTL VHKFNSWLDV
210 220 230 240 250
EPQVAEKLLA HPTQPSLACA ENFVKAIELN QNGAIWKLDL GTLEAIQWTK

HWDSGI
Length:256
Mass (Da):27,745
Last modified:January 23, 2007 - v5
Checksum:i2BEC8BDBFFD7E00B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52A → V in AAA28360 (PubMed:6427630).Curated1
Sequence conflicti156T → N in AAA28360 (PubMed:6427630).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00607 Genomic DNA. Translation: CAA25249.1.
M19276 Genomic DNA. Translation: AAA28360.1.
M19263 Genomic DNA. Translation: AAA28337.1.
M36581 Genomic DNA. Translation: AAA28333.1.
X57361 Genomic DNA. Translation: CAA40635.1.
X57362 Genomic DNA. Translation: CAA40636.1.
X57363 Genomic DNA. Translation: CAA40637.1.
X57364 Genomic DNA. Translation: CAA40638.1.
CM000361 Genomic DNA. Translation: EDX05053.1.
AY459545 Genomic DNA. Translation: AAR23003.1.
PIRiS18273.
RefSeqiXP_016024999.1. XM_016180148.1.

Genome annotation databases

EnsemblMetazoaiFBtr0223878; FBpp0222370; FBgn0012824.
GeneIDi6732347.
KEGGidsi:Dsimw501_GD23968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00607 Genomic DNA. Translation: CAA25249.1.
M19276 Genomic DNA. Translation: AAA28360.1.
M19263 Genomic DNA. Translation: AAA28337.1.
M36581 Genomic DNA. Translation: AAA28333.1.
X57361 Genomic DNA. Translation: CAA40635.1.
X57362 Genomic DNA. Translation: CAA40636.1.
X57363 Genomic DNA. Translation: CAA40637.1.
X57364 Genomic DNA. Translation: CAA40638.1.
CM000361 Genomic DNA. Translation: EDX05053.1.
AY459545 Genomic DNA. Translation: AAR23003.1.
PIRiS18273.
RefSeqiXP_016024999.1. XM_016180148.1.

3D structure databases

ProteinModelPortaliQ24641.
SMRiQ24641.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0223878; FBpp0222370; FBgn0012824.
GeneIDi6732347.
KEGGidsi:Dsimw501_GD23968.

Organism-specific databases

FlyBaseiFBgn0012824. Dsim\Adh.

Phylogenomic databases

KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiQ24641.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROSI
AccessioniPrimary (citable) accession number: Q24641
Secondary accession number(s): B4Q5K9, P07163, Q6SE55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: April 12, 2017
This is version 100 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.