Q24641 (ADH_DROSI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase
EC=1.1.1.1

Gene names

Name:	Adh
ORF Names:	GD23968

Organism

Drosophila simulans (Fruit fly) [Complete proteome]

Taxonomic identifier

7240 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alcohol metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 256	255	Alcohol dehydrogenase		PRO_0000054494
Regions
	Nucleotide binding	12 – 35	24	NAD By similarity
Sites
	Active site	153	1	Proton acceptor By similarity
	Binding site	140	1	Substrate By similarity
Experimental info
	Sequence conflict	52	1	A → V in AAA28360. Ref.2
	Sequence conflict	156	1	T → N in AAA28360. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q24641 [UniParc]. Last modified January 23, 2007. Version 5. Checksum: 2BEC8BDBFFD7E00B	FASTA	256	27,745
	10 20 30 40 50 60 MAFTLTNKNV IFVAGLGGIG LDTSKELLKR DLKNLVILDR IENPAAIAEL KAINPKVTVT 70 80 90 100 110 120 FYPYDVTVPI AETTKLLKTI FAKLKTVDVL INGAGILDDH QIERTIAVNY TGLVNTTTAI 130 140 150 160 170 180 LDFWDKRKGG PGGIICNIGS VTGFNAIYQV PVYSGTKAAV VNFTSSLAKL APITGVTAYT 190 200 210 220 230 240 VNPGITRTTL VHKFNSWLDV EPQVAEKLLA HPTQPSLACA ENFVKAIELN QNGAIWKLDL 250 GTLEAIQWTK HWDSGI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence comparison of the Adh gene in three drosophilids." Cohn V.H., Thompson M.A., Moore G.P. J. Mol. Evol. 20:31-37(1984) [PubMed: 6429340] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila." Bodmer M., Ashburner M. Nature 309:425-430(1984) [PubMed: 6427630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Organization and evolution of the alcohol dehydrogenase gene in Drosophila." Cohn V.H., Moore G.P. Mol. Biol. Evol. 5:154-166(1988) [PubMed: 3367783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Genetic basis of the difference in alcohol dehydrogenase expression between Drosophila melanogaster and Drosophila simulans." Laurie C.C., Heath E.M., Jacobson J.W., Thomson M.S. Proc. Natl. Acad. Sci. U.S.A. 87:9674-9678(1990) [PubMed: 2124699] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Adaptive protein evolution at the Adh locus in Drosophila." McDonald J.H., Kreitman M. Nature 351:652-654(1991) [PubMed: 1904993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Australia, Brazzaville, France and Ottawa.
[6]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila." Halligan D.L., Eyre-Walker A., Andolfatto P., Keightley P.D. Genome Res. 14:273-279(2004) [PubMed: 14762063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X00607 Genomic DNA. Translation: CAA25249.1. M19276 Genomic DNA. Translation: AAA28360.1. M19263 Genomic DNA. Translation: AAA28337.1. M36581 Genomic DNA. Translation: AAA28333.1. X57361 Genomic DNA. Translation: CAA40635.1. X57362 Genomic DNA. Translation: CAA40636.1. X57363 Genomic DNA. Translation: CAA40637.1. X57364 Genomic DNA. Translation: CAA40638.1. CM000361 Genomic DNA. Translation: EDX05053.1. AY459545 Genomic DNA. Translation: AAR23003.1.
PIR	S18273.
RefSeq	XP_002079468.1. XM_002079432.1.
UniGene	Dsi.1331.
3D structure databases
ProteinModelPortal	Q24641.
SMR	Q24641. Positions 2-256.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0223878; FBpp0222370; FBgn0012824.
GeneID	6732347.
KEGG	dsi:Dsim_GD23968.
Organism-specific databases
FlyBase	FBgn0012824. Dsim\Adh.
Phylogenomic databases
GeneTree	EMGT00050000006799.
OrthoDB	EOG40K6FN.
PhylomeDB	Q24641.
Family and domain databases
InterPro	IPR002425. ADH_Drosophila-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00001.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROSI

Accession

Primary (citable) accession number: Q24641
Secondary accession number(s): B4Q5K9, P07163, Q6SE55

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 75 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project